Basic Information
ID: ALA1954620
Type: Functional
Description: Antagonist activity at human nAChR alpha4/beta2 receptor expressed in HEK ts201 cells assessed as calcium accumulation by fluorescence analysis
Organism: Homo sapiens
Cell type: HEK ts201
Activity Charts
Bioactivity
Activity Types for Assay ALA1954620
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 394.52 | 4.15 | 4.15 |
| 405.46 | 5.21 | 5.21 |
| 413.56 | 5.86 | 5.86 |
| 482.58 | 4.99 | 4.99 |
| 413.56 | 5.86 | 5.86 |
| 462.59 | 4.48 | 4.48 |
| 367.49 | 4.20 | 4.20 |
| 371.91 | 4.84 | 4.84 |
| 524.66 | 5.48 | 5.48 |
| 530.71 | 5.89 | 5.89 |
| 479.57 | 4.92 | 4.92 |
| 479.57 | 4.92 | 4.92 |
| 492.06 | 7.13 | 7.13 |
| 487.64 | 6.48 | 6.48 |
| 295.38 | 3.51 | 3.51 |
| 309.41 | 3.85 | 3.85 |
| 324.44 | 4.00 | 4.00 |
| 293.41 | 4.32 | 4.32 |
| 378.48 | 4.92 | 4.92 |
| 480.61 | 5.57 | 5.57 |
| 480.61 | 5.44 | 5.44 |
| 497.64 | 5.74 | 5.74 |
| 532.64 | 3.97 | 3.97 |
| 421.54 | 4.51 | 4.51 |
| 442.51 | 2.36 | 2.36 |
| 456.54 | 2.74 | 2.74 |
| 412.58 | 5.31 | 5.31 |
| 578.80 | 8.89 | 8.89 |
| 412.58 | 5.43 | 5.43 |
| 463.62 | 7.01 | 7.01 |
| 448.56 | 4.09 | 4.09 |
| 448.56 | 4.09 | 4.09 |
| 473.57 | 4.18 | 4.18 |
| 413.56 | 5.74 | 5.74 |
| 544.61 | 6.14 | 6.14 |
| 480.56 | 3.54 | 3.54 |
| 476.62 | 4.87 | 4.87 |
| 490.64 | 5.26 | 5.26 |
| 464.56 | 3.84 | 3.84 |
| 484.98 | 4.19 | 4.19 |
| 500.60 | 4.69 | 4.69 |
| 500.60 | 4.69 | 4.69 |
| 526.63 | 5.20 | 5.20 |
| 478.59 | 4.31 | 4.31 |
| 492.62 | 4.70 | 4.70 |
| 522.64 | 4.71 | 4.71 |
| 547.48 | 5.62 | 5.62 |
| 561.51 | 6.01 | 6.01 |
| 281.40 | 3.87 | 3.87 |
| 559.11 | 5.96 | 5.96 |
| 538.69 | 5.70 | 5.70 |
| 448.56 | 4.09 | 4.09 |
| 552.67 | 4.72 | 4.72 |
| 552.67 | 4.72 | 4.72 |
| 516.64 | 3.05 | 3.05 |
| 554.69 | 5.32 | 5.32 |
| 434.54 | 3.70 | 3.70 |
| 510.63 | 4.92 | 4.92 |
| 522.65 | 5.23 | 5.23 |
| 399.58 | 6.22 | 6.22 |
| 413.56 | 5.86 | 5.86 |
| 480.66 | 5.85 | 5.85 |
| 454.61 | 4.82 | 4.82 |
| 519.43 | 4.84 | 4.84 |
| 287.36 | 4.28 | 4.28 |
| 273.33 | 4.61 | 4.61 |
| 337.42 | 5.44 | 5.44 |
| 274.32 | 4.00 | 4.00 |
| 275.31 | 3.40 | 3.40 |
| 323.40 | 5.76 | 5.76 |
| 413.52 | 5.13 | 5.13 |
| 427.54 | 5.38 | 5.38 |
| 419.44 | 4.73 | 4.73 |
| 427.54 | 5.38 | 5.38 |
| 399.53 | 5.61 | 5.61 |