Basic Information
ID: ALA1962031
Type: Binding
Description: GSK_PKIS: CDK6/cyclinD3 mean inhibition at 1 uM [Nanosyn]
Activity Charts
Bioactivity
Activity Types for Assay ALA1962031
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 297.36 | 3.86 | 3.86 |
| 371.40 | 4.03 | 4.03 |
| 382.44 | 2.45 | 2.45 |
| 440.48 | 4.73 | 4.73 |
| 415.47 | 4.86 | 4.86 |
| 507.57 | 6.66 | 6.66 |
| 366.44 | 3.47 | 3.47 |
| 433.46 | 5.00 | 5.00 |
| 493.56 | 4.27 | 4.27 |
| 483.47 | 5.88 | 5.88 |
| 458.50 | 3.96 | 3.96 |
| 449.92 | 5.52 | 5.52 |
| 445.50 | 4.87 | 4.87 |
| 471.58 | 6.16 | 6.16 |
| 433.46 | 5.00 | 5.00 |
| 459.48 | 4.59 | 4.59 |
| 443.53 | 5.43 | 5.43 |
| 395.47 | 4.23 | 4.23 |
| 373.42 | 3.36 | 3.36 |
| 326.36 | 2.57 | 2.57 |
| 358.41 | 3.58 | 3.58 |
| 362.37 | 3.41 | 3.41 |
| 422.47 | 2.67 | 2.67 |
| 284.28 | 1.51 | 1.51 |
| 345.37 | 2.67 | 2.67 |
| 362.37 | 3.41 | 3.41 |
| 372.44 | 3.48 | 3.48 |
| 374.40 | 3.28 | 3.28 |
| 428.52 | 5.16 | 5.16 |
| 352.42 | 3.00 | 3.00 |
| 396.47 | 2.82 | 2.82 |
| 394.50 | 4.21 | 4.21 |
| 236.27 | 4.09 | 4.09 |
| 330.37 | 2.17 | 2.17 |
| 348.36 | 2.31 | 2.31 |
| 370.43 | 2.95 | 2.95 |
| 356.41 | 2.23 | 2.23 |
| 295.32 | 3.72 | 3.72 |
| 268.28 | 2.57 | 2.57 |
| 370.43 | 2.95 | 2.95 |
| 320.35 | 2.13 | 2.13 |
| 324.77 | 2.77 | 2.77 |
| 294.31 | 2.17 | 2.17 |
| 314.73 | 2.53 | 2.53 |
| 377.18 | 3.17 | 3.17 |
| 349.17 | 3.18 | 3.18 |
| 394.17 | 3.09 | 3.09 |
| 383.62 | 3.83 | 3.83 |
| 264.28 | 2.17 | 2.17 |
| 377.18 | 3.17 | 3.17 |
| 502.16 | 5.48 | 5.48 |
| 263.30 | 3.20 | 3.20 |
| 296.33 | 4.10 | 4.10 |
| 326.35 | 4.11 | 4.11 |
| 401.49 | 4.12 | 4.12 |
| 392.86 | 4.54 | 4.54 |
| 388.45 | 3.90 | 3.90 |
| 376.41 | 4.03 | 4.03 |
| 293.33 | 3.55 | 3.55 |
| 287.33 | 3.39 | 3.39 |
| 305.37 | 3.40 | 3.40 |
| 322.37 | 4.14 | 4.14 |
| 338.82 | 4.66 | 4.66 |
| 346.35 | 2.70 | 2.70 |
| 490.45 | 5.39 | 5.39 |
| 402.34 | 3.84 | 3.84 |
| 468.39 | 5.89 | 5.89 |
| 330.40 | 4.05 | 4.05 |
| 430.39 | 4.36 | 4.36 |
| 446.44 | 5.92 | 5.92 |
| 396.43 | 5.04 | 5.04 |
| 348.37 | 2.95 | 2.95 |
| 400.36 | 4.35 | 4.35 |
| 432.41 | 5.62 | 5.62 |
| 430.42 | 4.88 | 4.88 |
| 490.45 | 5.39 | 5.39 |
| 452.47 | 4.38 | 4.38 |
| 440.44 | 4.51 | 4.51 |
| 398.86 | 5.25 | 5.25 |
| 504.47 | 5.70 | 5.70 |
| 462.44 | 5.62 | 5.62 |
| 318.34 | 2.94 | 2.94 |
| 496.88 | 6.28 | 6.28 |
| 573.56 | 5.18 | 5.18 |
| 247.23 | 1.83 | 1.83 |
| 274.28 | 1.48 | 1.48 |
| 230.23 | 1.08 | 1.08 |
| 284.32 | 2.57 | 2.57 |
| 258.29 | 1.65 | 1.65 |
| 299.34 | 1.68 | 1.68 |
| 242.24 | 1.40 | 1.40 |
| 216.20 | 0.60 | 0.60 |
| 229.24 | 1.69 | 1.69 |
| 307.32 | 1.51 | 1.51 |
| 571.49 | 6.48 | 6.48 |
| 287.33 | 1.02 | 1.02 |
| 250.30 | 4.39 | 4.39 |
| 400.46 | 4.09 | 4.09 |
| 452.51 | 5.69 | 5.69 |
| 315.35 | 2.73 | 2.73 |
| 241.25 | 2.48 | 2.48 |
| 241.25 | 2.48 | 2.48 |
| 328.38 | 4.21 | 4.21 |
| 316.34 | 4.34 | 4.34 |
| 340.43 | 5.32 | 5.32 |
| 408.47 | 4.48 | 4.48 |
| 427.51 | 3.91 | 3.91 |
| 344.38 | 3.47 | 3.47 |
| 345.37 | 2.67 | 2.67 |
| 444.90 | 5.57 | 5.57 |
| 486.93 | 5.95 | 5.95 |
| 429.88 | 5.99 | 5.99 |
| 446.87 | 4.36 | 4.36 |
| 487.92 | 5.34 | 5.34 |
| 486.93 | 5.35 | 5.35 |
| 500.96 | 5.63 | 5.63 |
| 644.12 | 8.00 | 8.00 |
| 620.11 | 6.38 | 6.38 |
| 614.62 | 6.50 | 6.50 |
| 393.45 | 6.21 | 6.21 |
| 283.33 | 3.36 | 3.36 |
| 296.37 | 3.28 | 3.28 |
| 266.34 | 3.23 | 3.23 |
| 268.32 | 2.67 | 2.67 |
| 325.41 | 4.53 | 4.53 |
| 294.40 | 3.74 | 3.74 |
| 307.18 | 3.92 | 3.92 |
| 252.32 | 2.92 | 2.92 |
| 272.74 | 3.27 | 3.27 |
| 339.40 | 2.95 | 2.95 |
| 484.52 | 4.19 | 4.19 |
| 365.37 | 2.97 | 2.97 |
| 415.28 | 4.39 | 4.39 |
| 396.45 | 4.23 | 4.23 |
| 428.41 | 4.41 | 4.41 |
| 448.83 | 4.75 | 4.75 |
| 469.54 | 3.96 | 3.96 |
| 457.94 | 5.00 | 5.00 |
| 453.54 | 3.89 | 3.89 |
| 307.33 | 3.24 | 3.24 |
| 381.46 | 3.07 | 3.07 |
| 289.34 | 3.10 | 3.10 |
| 228.25 | 1.86 | 1.86 |
| 416.89 | 3.43 | 3.43 |
| 445.48 | 5.74 | 5.74 |
| 332.43 | 4.90 | 4.90 |
| 350.42 | 5.04 | 5.04 |
| 300.36 | 3.89 | 3.89 |
| 300.36 | 3.89 | 3.89 |
| 401.49 | 4.71 | 4.71 |
| 453.57 | 5.72 | 5.72 |
| 467.59 | 6.02 | 6.02 |
| 483.59 | 5.69 | 5.69 |
| 328.39 | 3.40 | 3.40 |
| 433.92 | 4.65 | 4.65 |
| 345.37 | 2.94 | 2.94 |
| 431.35 | 5.27 | 5.27 |
| 481.36 | 6.15 | 6.15 |
| 413.36 | 5.13 | 5.13 |
| 373.21 | 3.44 | 3.44 |
| 313.31 | 3.86 | 3.86 |
| 356.41 | 2.23 | 2.23 |
| 277.33 | 3.58 | 3.58 |
| 308.34 | 2.98 | 2.98 |
| 430.31 | 3.37 | 3.37 |
| 347.17 | 3.33 | 3.33 |
| 366.42 | 2.83 | 2.83 |
| 394.43 | 5.14 | 5.14 |
| 333.39 | 3.85 | 3.85 |
| 413.48 | 4.96 | 4.96 |
| 417.90 | 5.60 | 5.60 |
| 445.50 | 0.85 | 0.85 |
| 450.48 | 1.43 | 1.43 |
| 467.51 | 1.12 | 1.12 |
| 453.48 | 0.80 | 0.80 |
| 415.47 | 2.55 | 2.55 |
| 370.43 | 2.53 | 2.53 |
| 358.42 | 1.81 | 1.81 |
| 383.39 | 1.76 | 1.76 |
| 350.79 | 1.76 | 1.76 |
| 329.38 | 2.13 | 2.13 |
| 330.37 | 1.41 | 1.41 |
| 367.39 | 1.65 | 1.65 |
| 358.42 | 2.23 | 2.23 |
| 372.43 | 2.35 | 2.35 |
| 438.55 | 3.15 | 3.15 |
| 608.10 | 5.36 | 5.36 |
| 330.35 | 0.03 | 0.03 |
| 566.06 | 5.63 | 5.63 |
| 566.06 | 5.59 | 5.59 |
| 566.06 | 5.59 | 5.59 |
| 415.50 | 3.84 | 3.84 |
| 603.17 | 6.67 | 6.67 |
| 451.91 | 7.07 | 7.07 |
| 564.09 | 6.81 | 6.81 |
| 467.98 | 7.53 | 7.53 |
| 492.48 | 5.49 | 5.49 |
| 476.48 | 5.90 | 5.90 |
| 491.49 | 5.06 | 5.06 |
| 505.52 | 5.40 | 5.40 |
| 379.44 | 3.77 | 3.77 |
| 428.31 | 4.53 | 4.53 |
| 496.31 | 5.55 | 5.55 |
| 496.31 | 5.55 | 5.55 |
| 477.46 | 4.80 | 4.80 |
| 443.91 | 4.44 | 4.44 |
| 423.49 | 3.82 | 3.82 |
| 457.94 | 5.00 | 5.00 |
| 427.91 | 4.99 | 4.99 |
| 461.47 | 5.35 | 5.35 |
| 390.53 | 4.86 | 4.86 |
| 350.46 | 3.94 | 3.94 |
| 362.47 | 4.08 | 4.08 |
| 336.44 | 4.15 | 4.15 |
| 362.47 | 4.54 | 4.54 |
| 374.44 | 4.65 | 4.65 |
| 334.42 | 3.39 | 3.39 |
| 454.57 | 5.05 | 5.05 |
| 470.57 | 4.29 | 4.29 |
| 406.45 | 4.17 | 4.17 |
| 291.35 | 3.43 | 3.43 |
| 313.32 | 2.80 | 2.80 |
| 280.34 | 2.32 | 2.32 |
| 337.39 | 1.60 | 1.60 |
| 294.24 | 2.16 | 2.16 |
| 336.79 | 3.45 | 3.45 |
| 339.40 | 1.32 | 1.32 |
| 454.46 | 3.70 | 3.70 |
| 483.58 | 3.86 | 3.86 |
| 519.58 | 4.82 | 4.82 |
| 520.62 | 3.45 | 3.45 |
| 548.67 | 4.19 | 4.19 |
| 518.60 | 4.22 | 4.22 |
| 568.05 | 5.60 | 5.60 |
| 506.54 | 3.50 | 3.50 |
| 520.57 | 3.52 | 3.52 |
| 601.69 | 3.61 | 3.61 |
| 508.63 | 5.53 | 5.53 |
| 592.68 | 3.21 | 3.21 |
| 481.60 | 5.35 | 5.35 |
| 517.61 | 5.28 | 5.28 |
| 517.61 | 5.28 | 5.28 |
| 528.62 | 7.34 | 7.34 |
| 494.45 | 5.12 | 5.12 |
| 289.31 | 4.20 | 4.20 |
| 352.44 | 2.23 | 2.23 |
| 459.43 | 4.89 | 4.89 |
| 483.53 | 5.66 | 5.66 |
| 390.46 | 4.13 | 4.13 |
| 390.46 | 4.13 | 4.13 |
| 599.54 | 6.00 | 6.00 |
| 467.81 | 5.27 | 5.27 |
| 363.85 | 5.05 | 5.05 |
| 395.47 | 4.30 | 4.30 |
| 395.47 | 1.80 | 1.80 |
| 447.50 | 2.28 | 2.28 |
| 447.50 | 2.28 | 2.28 |
| 275.31 | 3.07 | 3.07 |
| 472.52 | 3.89 | 3.89 |
| 486.55 | 4.28 | 4.28 |
| 451.45 | 5.14 | 5.14 |
| 360.38 | 2.98 | 2.98 |
| 374.40 | 3.03 | 3.03 |
| 400.22 | 5.02 | 5.02 |
| 508.60 | 5.47 | 5.47 |
| 453.09 | 4.20 | 4.20 |
| 529.64 | 5.12 | 5.12 |
| 372.43 | 2.35 | 2.35 |
| 303.32 | 2.67 | 2.67 |
| 292.30 | 2.26 | 2.26 |
| 329.38 | 2.46 | 2.46 |
| 315.35 | 1.74 | 1.74 |
| 332.79 | 4.10 | 4.10 |
| 297.74 | 3.96 | 3.96 |
| 302.76 | 4.09 | 4.09 |
| 470.41 | 0.12 | 0.12 |
| 539.52 | 1.58 | 1.58 |
| 525.49 | 1.34 | 1.34 |
| 487.97 | 3.71 | 3.71 |
| 558.63 | 6.07 | 6.07 |
| 525.07 | 5.70 | 5.70 |
| 511.05 | 5.45 | 5.45 |
| 409.92 | 3.73 | 3.73 |
| 490.00 | 5.74 | 5.74 |
| 459.96 | 2.83 | 2.83 |
| 520.95 | 5.01 | 5.01 |
| 373.46 | 3.77 | 3.77 |
| 370.39 | 4.04 | 4.04 |
| 353.40 | 3.20 | 3.20 |
| 529.61 | 3.05 | 3.05 |
| 364.83 | 5.88 | 5.88 |
| 395.44 | 1.77 | 1.77 |
| 394.31 | 1.76 | 1.76 |
| 372.86 | 2.30 | 2.30 |
| 422.87 | 2.97 | 2.97 |
| 546.38 | 3.37 | 3.37 |
| 561.52 | 2.28 | 2.28 |
| 421.89 | 0.80 | 0.80 |
| 368.82 | 2.61 | 2.61 |
| 329.79 | 2.75 | 2.75 |
| 379.85 | 4.31 | 4.31 |
| 390.88 | 4.11 | 4.11 |
| 528.46 | 4.42 | 4.42 |
| 650.15 | 6.23 | 6.23 |
| 347.80 | 3.40 | 3.40 |
| 489.00 | 3.98 | 3.98 |
| 459.96 | 2.83 | 2.83 |
| 665.22 | 4.56 | 4.56 |
| 576.12 | 2.99 | 2.99 |
| 534.09 | 3.22 | 3.22 |
| 607.07 | 3.84 | 3.84 |
| 488.33 | 5.83 | 5.83 |
| 617.56 | 6.69 | 6.69 |
| 539.87 | 6.34 | 6.34 |
| 587.94 | 5.38 | 5.38 |
| 575.91 | 7.00 | 7.00 |
| 556.93 | 7.07 | 7.07 |
| 532.78 | 5.94 | 5.94 |
| 453.89 | 5.18 | 5.18 |
| 622.07 | 6.21 | 6.21 |
| 497.90 | 4.88 | 4.88 |
| 585.95 | 7.41 | 7.41 |
| 525.49 | 1.34 | 1.34 |
| 378.82 | 0.13 | 0.13 |
| 341.80 | 3.29 | 3.29 |
| 420.86 | 3.63 | 3.63 |
| 387.87 | 4.84 | 4.84 |
| 447.93 | 4.79 | 4.79 |
| 371.83 | 3.08 | 3.08 |
| 359.79 | 3.20 | 3.20 |
| 494.99 | 2.56 | 2.56 |
| 378.82 | 0.26 | 0.26 |
| 565.10 | 5.35 | 5.35 |
| 565.10 | 5.35 | 5.35 |
| 633.09 | 6.37 | 6.37 |
| 565.10 | 5.35 | 5.35 |
| 633.09 | 6.37 | 6.37 |
| 691.10 | 6.57 | 6.57 |
| 579.10 | 5.92 | 5.92 |
| 643.99 | 6.11 | 6.11 |
| 595.55 | 6.43 | 6.43 |
| 659.61 | 7.26 | 7.26 |
| 679.60 | 7.57 | 7.57 |
| 573.93 | 6.95 | 6.95 |
| 364.81 | 2.06 | 2.06 |
| 330.37 | 1.41 | 1.41 |
| 457.94 | 2.28 | 2.28 |
| 557.55 | 5.48 | 5.48 |
| 465.41 | 4.56 | 4.56 |
| 373.31 | 4.20 | 4.20 |
| 547.47 | 4.41 | 4.41 |
| 406.42 | 2.49 | 2.49 |
| 554.57 | 4.98 | 4.98 |
| 333.82 | 3.86 | 3.86 |
| 374.85 | 2.65 | 2.65 |
| 616.15 | 4.38 | 4.38 |
| 653.68 | 4.58 | 4.58 |
| 728.70 | 5.27 | 5.27 |
| 393.87 | 4.96 | 4.96 |
| 413.31 | 4.62 | 4.62 |
| 349.82 | 4.51 | 4.51 |
| 508.02 | 4.87 | 4.87 |
| 487.39 | 6.80 | 6.80 |
| 385.38 | 3.86 | 3.86 |
| 550.52 | 3.36 | 3.36 |
| 598.48 | 4.51 | 4.51 |