Basic Information
ID: ALA1963974
Type: Functional
Description: PUBCHEM_BIOASSAY: Counterscreen assay for antagonists of the orexin 1 receptor (OX1R; HCRTR1): Fluorescence-based cell-based dose response assay for antagonists of the orexin 2 receptor (OX2R; HCRTR2), run by assay provider. (Class of assay: confirmatory)
Activity Charts
Bioactivity
Activity Types for Assay ALA1963974
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 301.35 | 2.60 | 2.60 |
| 439.50 | 5.32 | 5.32 |
| 377.44 | 3.77 | 3.77 |
| 361.49 | 4.51 | 4.51 |
| 301.37 | 3.99 | 3.99 |
| 249.27 | 0.77 | 0.77 |
| 447.49 | 4.85 | 4.85 |
| 494.62 | 4.59 | 4.59 |
| 457.32 | 3.51 | 3.51 |
| 442.52 | 4.42 | 4.42 |
| 403.46 | 2.58 | 2.58 |
| 273.31 | 3.24 | 3.24 |
| 457.56 | 4.61 | 4.61 |
| 472.53 | 4.56 | 4.56 |
| 426.48 | 3.55 | 3.55 |
| 249.27 | 3.68 | 3.68 |
| 496.62 | 2.88 | 2.88 |
| 363.44 | 2.83 | 2.83 |
| 345.40 | 3.50 | 3.50 |
| 522.95 | 5.56 | 5.56 |
| 257.31 | 3.68 | 3.68 |
| 337.40 | 4.25 | 4.25 |
| 383.48 | 2.03 | 2.03 |
| 313.14 | 2.67 | 2.67 |
| 271.35 | 3.53 | 3.53 |
| 398.45 | 5.27 | 5.27 |
| 310.78 | 4.13 | 4.13 |
| 342.38 | 3.33 | 3.33 |
| 310.36 | 3.49 | 3.49 |
| 340.38 | 5.05 | 5.05 |
| 374.44 | 5.08 | 5.08 |
| 452.92 | 3.53 | 3.53 |
| 322.41 | 4.84 | 4.84 |
| 392.50 | 2.27 | 2.27 |
| 267.36 | 3.43 | 3.43 |
| 598.50 | 4.64 | 4.64 |
| 482.59 | 3.01 | 3.01 |
| 501.54 | 5.36 | 5.36 |
| 397.50 | 3.01 | 3.01 |
| 408.52 | 3.59 | 3.59 |
| 420.48 | 2.84 | 2.84 |
| 254.29 | 2.97 | 2.97 |
| 277.35 | 3.91 | 3.91 |
| 308.37 | 3.53 | 3.53 |
| 454.62 | 4.47 | 4.47 |
| 431.50 | 3.08 | 3.08 |
| 472.94 | 5.33 | 5.33 |
| 461.43 | 4.02 | 4.02 |
| 239.27 | 3.50 | 3.50 |
| 300.43 | 4.95 | 4.95 |
| 302.18 | 3.78 | 3.78 |
| 336.39 | 3.83 | 3.83 |
| 312.35 | 4.06 | 4.06 |
| 374.44 | 5.08 | 5.08 |
| 283.76 | 3.85 | 3.85 |
| 540.64 | 3.23 | 3.23 |
| 486.41 | 3.62 | 3.62 |
| 324.41 | 3.88 | 3.88 |
| 446.87 | 4.22 | 4.22 |
| 353.39 | 3.40 | 3.40 |
| 733.91 | 6.83 | 6.83 |
| 465.58 | 3.85 | 3.85 |
| 357.37 | 3.26 | 3.26 |
| 282.37 | 4.37 | 4.37 |
| 307.42 | 4.09 | 4.09 |
| 357.49 | 4.88 | 4.88 |
| 568.93 | 6.24 | 6.24 |
| 374.39 | 1.77 | 1.77 |
| 354.46 | 4.41 | 4.41 |
| 311.41 | 3.72 | 3.72 |
| 359.38 | 4.29 | 4.29 |
| 396.56 | 3.51 | 3.51 |
| 501.07 | 5.06 | 5.06 |
| 316.41 | 3.45 | 3.45 |
| 353.36 | 5.98 | 5.98 |
| 364.50 | 3.84 | 3.84 |
| 397.41 | 3.03 | 3.03 |
| 246.27 | 4.04 | 4.04 |
| 379.51 | 5.15 | 5.15 |
| 406.89 | 3.50 | 3.50 |
| 426.52 | 4.72 | 4.72 |
| 290.29 | 4.18 | 4.18 |
| 341.37 | 5.10 | 5.10 |
| 492.56 | 3.83 | 3.83 |
| 426.52 | 4.72 | 4.72 |
| 281.34 | 4.32 | 4.32 |
| 408.52 | 3.77 | 3.77 |
| 426.45 | 2.86 | 2.86 |
| 403.48 | 3.87 | 3.87 |
| 457.55 | 3.16 | 3.16 |
| 263.30 | 3.19 | 3.19 |
| 435.51 | 3.78 | 3.78 |
| 369.43 | 4.13 | 4.13 |
| 323.35 | 3.36 | 3.36 |
| 455.01 | 6.21 | 6.21 |
| 302.77 | 3.11 | 3.11 |
| 242.30 | 3.43 | 3.43 |
| 484.95 | 5.49 | 5.49 |
| 469.59 | 5.01 | 5.01 |
| 416.54 | 3.74 | 3.74 |
| 430.90 | 5.33 | 5.33 |
| 398.91 | 4.84 | 4.84 |
| 247.30 | 3.76 | 3.76 |
| 387.46 | 5.87 | 5.87 |
| 303.41 | 2.78 | 2.78 |
| 318.45 | 4.24 | 4.24 |
| 300.70 | 4.17 | 4.17 |
| 247.30 | 3.58 | 3.58 |
| 462.55 | 3.36 | 3.36 |
| 324.38 | 3.67 | 3.67 |
| 232.31 | 2.69 | 2.69 |
| 365.84 | 5.32 | 5.32 |
| 341.42 | 4.57 | 4.57 |
| 347.42 | 4.19 | 4.19 |
| 311.34 | 5.09 | 5.09 |
| 239.27 | 2.82 | 2.82 |
| 330.39 | 3.70 | 3.70 |
| 447.50 | 2.32 | 2.32 |
| 252.30 | 2.87 | 2.87 |
| 464.60 | 5.02 | 5.02 |
| 352.37 | 2.97 | 2.97 |
| 314.41 | 2.94 | 2.94 |
| 260.30 | 4.35 | 4.35 |
| 362.43 | 4.05 | 4.05 |
| 454.90 | 5.25 | 5.25 |
| 267.72 | 3.93 | 3.93 |
| 323.40 | 2.44 | 2.44 |
| 433.49 | 4.30 | 4.30 |
| 447.52 | 2.78 | 2.78 |
| 321.41 | 4.33 | 4.33 |
| 340.40 | 4.32 | 4.32 |
| 249.27 | 3.41 | 3.41 |
| 278.34 | 3.33 | 3.33 |
| 337.44 | 3.99 | 3.99 |
| 547.05 | 5.87 | 5.87 |
| 314.39 | 4.26 | 4.26 |
| 329.41 | 3.53 | 3.53 |
| 386.48 | 2.54 | 2.54 |
| 350.38 | 3.01 | 3.01 |
| 420.47 | 4.37 | 4.37 |
| 336.39 | 4.14 | 4.14 |
| 408.45 | 2.76 | 2.76 |
| 363.51 | 4.94 | 4.94 |
| 459.55 | 3.09 | 3.09 |
| 327.34 | 3.75 | 3.75 |
| 353.43 | 5.44 | 5.44 |
| 482.03 | 6.09 | 6.09 |
| 340.85 | 4.05 | 4.05 |
| 440.50 | 2.98 | 2.98 |
| 344.41 | 5.08 | 5.08 |
| 415.46 | 2.47 | 2.47 |
| 300.47 | 3.36 | 3.36 |
| 363.39 | 4.53 | 4.53 |
| 508.48 | 5.89 | 5.89 |
| 385.36 | 5.38 | 5.38 |
| 322.18 | 4.07 | 4.07 |
| 435.44 | 3.01 | 3.01 |
| 483.55 | 5.23 | 5.23 |
| 351.36 | 2.83 | 2.83 |
| 455.49 | 3.65 | 3.65 |
| 389.51 | 5.55 | 5.55 |
| 395.46 | 4.76 | 4.76 |
| 310.37 | 3.48 | 3.48 |
| 459.96 | 4.06 | 4.06 |
| 396.53 | 4.90 | 4.90 |
| 428.56 | 4.60 | 4.60 |
| 312.42 | 4.18 | 4.18 |
| 342.42 | 3.68 | 3.68 |
| 499.66 | 3.68 | 3.68 |
| 356.45 | 3.41 | 3.41 |
| 482.00 | 5.84 | 5.84 |
| 412.43 | 3.81 | 3.81 |
| 217.27 | 2.96 | 2.96 |
| 450.00 | 4.19 | 4.19 |
| 351.40 | 3.95 | 3.95 |
| 429.35 | 5.17 | 5.17 |
| 378.88 | 3.44 | 3.44 |
| 382.44 | 3.07 | 3.07 |
| 374.98 | 4.43 | 4.43 |
| 279.28 | 3.16 | 3.16 |
| 356.45 | 3.99 | 3.99 |
| 394.88 | 3.14 | 3.14 |
| 356.42 | 2.64 | 2.64 |
| 384.48 | 3.42 | 3.42 |
| 374.49 | 4.41 | 4.41 |
| 558.72 | 3.48 | 3.48 |
| 428.51 | 3.38 | 3.38 |
| 313.41 | 3.42 | 3.42 |
| 498.00 | 5.55 | 5.55 |
| 292.39 | 2.16 | 2.16 |
| 352.45 | 3.57 | 3.57 |
| 395.44 | 2.39 | 2.39 |
| 262.33 | 2.32 | 2.32 |
| 384.44 | 3.64 | 3.64 |
| 450.95 | 4.37 | 4.37 |
| 271.28 | 2.77 | 2.77 |
| 383.40 | 2.97 | 2.97 |
| 390.47 | 3.70 | 3.70 |
| 446.54 | 5.81 | 5.81 |
| 560.59 | 2.88 | 2.88 |
| 279.34 | 3.65 | 3.65 |
| 397.89 | 5.12 | 5.12 |
| 294.31 | 2.55 | 2.55 |
| 399.25 | 4.13 | 4.13 |
| 388.28 | 5.45 | 5.45 |
| 447.46 | 1.64 | 1.64 |
| 376.46 | 3.10 | 3.10 |
| 269.33 | 2.83 | 2.83 |
| 346.46 | 4.59 | 4.59 |
| 481.51 | 1.59 | 1.59 |
| 334.43 | 3.20 | 3.20 |
| 350.38 | 3.32 | 3.32 |
| 495.40 | 4.48 | 4.48 |