Basic Information
ID: ALA1964050
Type: Functional
Description: PUBCHEM_BIOASSAY: Counterscreen for biased ligands (antagonists) of the melanocortin 4 receptor (MC4R): TRFRET-based cell-based high throughput dose response assay to identify nonselective inhibitors of cAMP signaling. (Class of assay: confirmatory)
Activity Charts
Bioactivity
Activity Types for Assay ALA1964050
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 268.23 | 2.40 | 2.40 |
| 505.46 | 4.18 | 4.18 |
| 289.74 | 4.31 | 4.31 |
| 325.35 | -1.74 | -1.74 |
| 356.18 | 5.18 | 5.18 |
| 430.54 | 6.42 | 6.42 |
| 637.04 | 5.55 | 5.55 |
| 517.64 | 2.55 | 2.55 |
| 449.51 | 4.17 | 4.17 |
| 280.29 | 2.19 | 2.19 |
| 284.27 | 2.48 | 2.48 |
| 489.60 | 5.21 | 5.21 |
| 356.85 | 2.04 | 2.04 |
| 408.72 | 5.26 | 5.26 |
| 257.29 | 2.79 | 2.79 |
| 541.92 | 4.18 | 4.18 |
| 397.48 | 2.18 | 2.18 |
| 455.47 | 3.93 | 3.93 |
| 487.00 | 2.60 | 2.60 |
| 423.54 | 3.96 | 3.96 |
| 359.43 | 3.68 | 3.68 |
| 395.24 | 2.93 | 2.93 |
| 408.19 | 5.02 | 5.02 |
| 302.81 | 3.41 | 3.41 |
| 369.52 | 4.74 | 4.74 |
| 425.87 | 3.17 | 3.17 |
| 394.34 | 0.33 | 0.33 |
| 305.81 | 3.58 | 3.58 |
| 427.43 | 2.14 | 2.14 |
| 325.80 | 4.03 | 4.03 |
| 426.52 | 1.52 | 1.52 |
| 432.32 | 4.52 | 4.52 |
| 410.74 | 3.75 | 3.75 |
| 373.31 | 3.33 | 3.33 |
| 463.54 | 4.46 | 4.46 |
| 458.90 | 4.48 | 4.48 |
| 374.50 | 4.61 | 4.61 |
| 309.79 | 3.06 | 3.06 |
| 428.51 | 3.06 | 3.06 |
| 279.39 | 3.34 | 3.34 |
| 361.23 | 4.86 | 4.86 |
| 403.36 | 3.92 | 3.92 |
| 358.85 | 4.15 | 4.15 |
| 391.43 | 2.51 | 2.51 |
| 398.56 | 4.65 | 4.65 |
| 325.39 | 2.85 | 2.85 |
| 640.75 | 6.38 | 6.38 |
| 483.93 | 2.94 | 2.94 |
| 448.51 | 5.82 | 5.82 |
| 487.00 | 2.74 | 2.74 |
| 436.49 | 4.21 | 4.21 |
| 325.80 | 1.14 | 1.14 |
| 399.36 | 2.24 | 2.24 |
| 348.79 | 3.41 | 3.41 |
| 484.61 | 5.99 | 5.99 |
| 410.43 | 4.14 | 4.14 |
| 482.51 | 3.36 | 3.36 |
| 389.86 | 2.23 | 2.23 |
| 407.75 | 3.98 | 3.98 |
| 386.52 | 5.66 | 5.66 |
| 365.42 | 0.46 | 0.46 |
| 377.37 | 1.81 | 1.81 |
| 520.01 | 5.01 | 5.01 |
| 369.38 | 4.20 | 4.20 |
| 319.67 | 2.09 | 2.09 |
| 360.37 | 1.58 | 1.58 |
| 597.67 | 4.77 | 4.77 |
| 411.37 | 1.44 | 1.44 |
| 423.86 | 3.49 | 3.49 |
| 373.80 | 3.74 | 3.74 |
| 451.51 | 2.72 | 2.72 |
| 520.37 | 2.71 | 2.71 |
| 412.49 | 4.05 | 4.05 |
| 440.94 | 4.00 | 4.00 |
| 233.66 | 2.77 | 2.77 |
| 260.14 | 3.51 | 3.51 |
| 453.93 | 3.13 | 3.13 |
| 409.46 | 2.56 | 2.56 |
| 324.41 | 3.49 | 3.49 |
| 271.23 | 2.37 | 2.37 |
| 364.25 | 1.47 | 1.47 |
| 448.97 | 3.53 | 3.53 |
| 425.62 | 4.08 | 4.08 |
| 319.74 | 3.40 | 3.40 |
| 435.52 | 2.95 | 2.95 |
| 373.27 | 5.08 | 5.08 |
| 447.43 | 2.74 | 2.74 |
| 412.51 | 3.53 | 3.53 |
| 487.00 | 2.60 | 2.60 |
| 459.91 | 3.07 | 3.07 |
| 433.51 | 3.50 | 3.50 |
| 403.47 | 3.85 | 3.85 |
| 487.01 | 4.54 | 4.54 |
| 314.34 | 2.38 | 2.38 |
| 297.81 | 2.79 | 2.79 |
| 539.43 | 3.90 | 3.90 |
| 347.78 | 4.42 | 4.42 |
| 364.45 | 4.45 | 4.45 |
| 409.46 | 2.03 | 2.03 |
| 426.47 | 3.97 | 3.97 |
| 288.69 | 3.27 | 3.27 |
| 413.43 | 3.87 | 3.87 |
| 293.77 | 3.91 | 3.91 |
| 372.17 | 4.09 | 4.09 |
| 269.34 | 3.89 | 3.89 |
| 470.53 | 1.54 | 1.54 |
| 384.39 | 4.77 | 4.77 |
| 385.46 | 5.57 | 5.57 |
| 449.51 | 3.34 | 3.34 |
| 419.72 | 4.28 | 4.28 |
| 498.79 | 5.52 | 5.52 |
| 335.83 | 3.79 | 3.79 |
| 413.47 | 3.31 | 3.31 |
| 477.41 | 5.08 | 5.08 |
| 340.81 | 4.51 | 4.51 |
| 287.70 | 3.92 | 3.92 |
| 391.47 | 4.30 | 4.30 |
| 442.12 | 3.59 | 3.59 |
| 441.24 | 4.83 | 4.83 |
| 277.66 | 3.74 | 3.74 |
| 348.42 | 3.24 | 3.24 |
| 394.47 | 5.43 | 5.43 |
| 340.40 | 3.44 | 3.44 |
| 397.30 | 4.79 | 4.79 |
| 357.34 | 2.72 | 2.72 |
| 563.68 | 3.99 | 3.99 |
| 431.53 | 4.99 | 4.99 |
| 562.67 | 4.30 | 4.30 |
| 464.62 | 5.53 | 5.53 |
| 402.47 | 2.72 | 2.72 |
| 535.44 | 4.06 | 4.06 |
| 261.35 | 3.26 | 3.26 |
| 457.47 | 5.33 | 5.33 |
| 475.57 | 5.76 | 5.76 |
| 320.37 | 2.45 | 2.45 |
| 469.99 | 4.44 | 4.44 |
| 444.13 | 5.32 | 5.32 |
| 530.56 | 0.69 | 0.69 |
| 377.47 | 4.06 | 4.06 |
| 419.98 | 3.31 | 3.31 |
| 469.28 | 4.00 | 4.00 |
| 420.42 | 4.65 | 4.65 |
| 422.46 | 3.58 | 3.58 |
| 301.78 | 4.11 | 4.11 |
| 551.08 | 9.23 | 9.23 |
| 268.29 | 0.84 | 0.84 |
| 417.40 | 2.73 | 2.73 |
| 466.97 | 3.10 | 3.10 |
| 517.57 | 6.45 | 6.45 |
| 425.55 | 2.38 | 2.38 |
| 284.31 | 3.74 | 3.74 |
| 510.47 | 5.62 | 5.62 |
| 487.56 | 3.27 | 3.27 |
| 530.54 | 4.31 | 4.31 |
| 439.54 | 3.48 | 3.48 |
| 385.44 | 0.39 | 0.39 |
| 369.42 | 3.37 | 3.37 |
| 422.32 | 2.72 | 2.72 |
| 499.40 | 3.79 | 3.79 |
| 482.45 | 3.66 | 3.66 |
| 423.49 | 2.51 | 2.51 |
| 466.90 | 4.16 | 4.16 |
| 537.05 | 8.84 | 8.84 |
| 362.43 | 5.41 | 5.41 |
| 344.47 | 3.41 | 3.41 |
| 367.40 | 3.26 | 3.26 |
| 402.47 | 2.00 | 2.00 |
| 350.42 | 4.42 | 4.42 |
| 412.51 | 3.53 | 3.53 |
| 490.84 | 4.85 | 4.85 |
| 385.55 | 5.96 | 5.96 |
| 428.44 | 5.55 | 5.55 |
| 498.36 | 4.80 | 4.80 |
| 349.95 | 4.46 | 4.46 |
| 647.69 | 3.54 | 3.54 |
| 405.45 | 3.36 | 3.36 |
| 431.32 | 3.78 | 3.78 |
| 563.88 | 5.26 | 5.26 |
| 203.29 | 1.92 | 1.92 |
| 310.33 | 1.22 | 1.22 |
| 422.51 | 2.95 | 2.95 |
| 359.81 | 4.49 | 4.49 |
| 417.98 | 4.67 | 4.67 |
| 414.09 | 7.88 | 7.88 |
| 376.38 | 3.59 | 3.59 |
| 385.20 | 2.18 | 2.18 |
| 549.99 | ||
| 643.66 | 5.74 | 5.74 |
| 674.77 | 6.43 | 6.43 |
| 382.59 | 5.64 | 5.64 |
| 572.68 | 4.76 | 4.76 |
| 437.54 | 4.75 | 4.75 |
| 412.57 | 5.24 | 5.24 |
| 387.59 | 5.57 | 5.57 |
| 350.12 | 3.14 | 3.14 |
| 449.49 | 3.82 | 3.82 |
| 331.38 | 2.86 | 2.86 |
| 429.52 | 3.72 | 3.72 |
| 426.49 | 2.64 | 2.64 |
| 431.88 | 3.59 | 3.59 |
| 435.36 | 4.17 | 4.17 |
| 479.63 | 3.97 | 3.97 |
| 315.38 | 3.16 | 3.16 |
| 562.73 | 3.99 | 3.99 |
| 438.68 | 2.48 | 2.48 |
| 414.44 | 2.75 | 2.75 |
| 432.45 | 2.44 | 2.44 |
| 361.10 | 3.42 | 3.42 |
| 387.42 | 2.07 | 2.07 |
| 428.50 | 3.69 | 3.69 |
| 533.57 | 6.15 | 6.15 |
| 488.55 | 4.20 | 4.20 |
| 411.49 | 3.35 | 3.35 |
| 463.99 | 4.15 | 4.15 |
| 341.37 | 1.14 | 1.14 |
| 482.51 | 3.27 | 3.27 |
| 343.34 | 2.58 | 2.58 |
| 460.61 | 4.54 | 4.54 |
| 402.50 | 3.21 | 3.21 |
| 504.66 | 4.29 | 4.29 |
| 470.61 | 3.35 | 3.35 |
| 450.51 | 2.48 | 2.48 |