Basic Information
ID: ALA1964096
Type: Functional
Description: PUBCHEM_BIOASSAY: Dose Response validation of uHTS RPN11 inhibitor hits using a Thrombin Fluorescence Polarization assay. (Class of assay: confirmatory)
Activity Charts
Bioactivity
Activity Types for Assay ALA1964096
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 306.32 | 2.59 | 2.59 |
| 280.28 | 2.64 | 2.64 |
| 216.28 | 2.38 | 2.38 |
| 483.64 | 5.45 | 5.45 |
| 255.32 | 3.72 | 3.72 |
| 430.53 | 4.62 | 4.62 |
| 372.38 | 4.25 | 4.25 |
| 270.24 | 2.42 | 2.42 |
| 443.50 | 4.27 | 4.27 |
| 366.49 | 3.51 | 3.51 |
| 262.31 | 3.77 | 3.77 |
| 448.58 | 4.92 | 4.92 |
| 382.40 | 3.58 | 3.58 |
| 361.40 | 2.98 | 2.98 |
| 251.35 | 1.17 | 1.17 |
| 496.56 | 5.36 | 5.36 |
| 444.92 | 3.88 | 3.88 |
| 458.56 | 4.03 | 4.03 |
| 417.47 | 2.76 | 2.76 |
| 445.97 | 3.64 | 3.64 |
| 447.93 | 3.06 | 3.06 |
| 533.67 | 6.30 | 6.30 |
| 326.74 | 2.88 | 2.88 |
| 416.51 | 4.23 | 4.23 |
| 471.68 | 6.06 | 6.06 |
| 288.30 | 4.32 | 4.32 |
| 370.84 | 4.18 | 4.18 |
| 381.50 | 4.41 | 4.41 |
| 503.40 | 4.84 | 4.84 |
| 474.58 | 1.94 | 1.94 |
| 332.15 | 3.85 | 3.85 |
| 274.35 | 2.77 | 2.77 |
| 372.50 | 4.52 | 4.52 |
| 359.86 | 5.67 | 5.67 |
| 417.53 | 3.01 | 3.01 |
| 431.95 | 5.94 | 5.94 |
| 391.33 | 5.08 | 5.08 |
| 474.53 | 3.97 | 3.97 |
| 452.56 | 4.56 | 4.56 |
| 331.36 | 2.70 | 2.70 |
| 355.42 | 3.78 | 3.78 |
| 440.55 | 4.18 | 4.18 |
| 293.37 | 3.14 | 3.14 |
| 309.32 | 2.63 | 2.63 |
| 320.35 | 3.24 | 3.24 |
| 396.43 | 2.34 | 2.34 |
| 332.43 | 2.50 | 2.50 |
| 281.31 | 1.75 | 1.75 |
| 413.48 | 2.41 | 2.41 |
| 452.52 | 3.86 | 3.86 |
| 440.98 | 3.42 | 3.42 |
| 305.33 | 3.84 | 3.84 |
| 251.35 | 1.17 | 1.17 |
| 490.59 | 5.01 | 5.01 |
| 327.32 | 4.20 | 4.20 |
| 308.36 | 2.70 | 2.70 |
| 424.48 | 2.08 | 2.08 |
| 386.41 | 3.98 | 3.98 |
| 390.46 | 2.65 | 2.65 |
| 427.51 | 2.66 | 2.66 |
| 373.21 | 3.98 | 3.98 |
| 354.43 | 3.56 | 3.56 |
| 493.39 | 4.68 | 4.68 |
| 296.40 | 4.22 | 4.22 |
| 425.33 | 4.55 | 4.55 |
| 401.47 | 2.73 | 2.73 |
| 342.35 | 4.11 | 4.11 |
| 304.35 | 2.43 | 2.43 |
| 376.37 | 3.88 | 3.88 |
| 365.41 | 4.52 | 4.52 |
| 388.42 | 3.81 | 3.81 |
| 299.33 | 3.24 | 3.24 |
| 304.35 | 4.89 | 4.89 |
| 324.34 | 4.19 | 4.19 |
| 458.55 | 3.55 | 3.55 |
| 448.43 | 4.92 | 4.92 |
| 387.40 | 2.64 | 2.64 |
| 426.52 | 4.15 | 4.15 |
| 368.46 | 3.55 | 3.55 |
| 362.45 | 5.05 | 5.05 |
| 419.46 | 3.54 | 3.54 |
| 466.54 | 2.58 | 2.58 |
| 357.39 | 3.53 | 3.53 |
| 368.49 | 4.48 | 4.48 |
| 462.64 | 5.12 | 5.12 |
| 493.55 | 2.25 | 2.25 |
| 402.33 | 4.58 | 4.58 |
| 450.52 | 3.18 | 3.18 |
| 368.44 | 2.19 | 2.19 |
| 422.45 | 1.77 | 1.77 |
| 443.55 | 4.54 | 4.54 |
| 460.00 | 4.03 | 4.03 |
| 265.38 | 4.84 | 4.84 |
| 398.37 | 1.66 | 1.66 |
| 279.27 | 3.60 | 3.60 |
| 465.51 | 4.37 | 4.37 |
| 445.29 | 4.53 | 4.53 |
| 558.62 | 3.65 | 3.65 |
| 478.50 | 3.72 | 3.72 |
| 388.28 | 6.16 | 6.16 |
| 437.30 | 3.30 | 3.30 |
| 208.17 | 0.25 | 0.25 |
| 373.49 | 3.79 | 3.79 |
| 408.46 | 1.80 | 1.80 |
| 486.55 | 2.61 | 2.61 |
| 455.56 | 3.14 | 3.14 |
| 473.49 | 6.22 | 6.22 |
| 192.29 | 2.61 | 2.61 |
| 526.59 | 4.69 | 4.69 |
| 326.31 | 1.95 | 1.95 |
| 387.44 | 3.12 | 3.12 |
| 326.36 | 4.54 | 4.54 |
| 381.48 | 4.51 | 4.51 |
| 401.90 | 4.22 | 4.22 |
| 398.49 | 1.94 | 1.94 |
| 314.44 | 4.45 | 4.45 |
| 384.49 | 3.76 | 3.76 |
| 429.43 | 4.59 | 4.59 |
| 450.52 | 2.85 | 2.85 |
| 302.33 | 4.69 | 4.69 |
| 252.36 | 2.13 | 2.13 |
| 341.39 | 1.97 | 1.97 |
| 506.63 | 5.30 | 5.30 |
| 315.33 | 3.38 | 3.38 |
| 373.42 | 2.55 | 2.55 |
| 296.28 | 2.25 | 2.25 |
| 427.51 | 2.72 | 2.72 |
| 310.31 | 2.40 | 2.40 |
| 500.51 | 3.99 | 3.99 |
| 438.55 | 3.58 | 3.58 |
| 347.42 | 3.50 | 3.50 |
| 539.59 | 2.13 | 2.13 |
| 484.60 | 4.28 | 4.28 |
| 476.41 | 4.20 | 4.20 |
| 299.33 | 1.69 | 1.69 |
| 473.62 | 3.72 | 3.72 |
| 464.89 | 4.63 | 4.63 |
| 250.27 | 2.98 | 2.98 |
| 441.49 | 3.43 | 3.43 |
| 498.54 | 3.51 | 3.51 |
| 339.38 | 2.15 | 2.15 |
| 438.53 | 4.85 | 4.85 |
| 474.48 | 2.13 | 2.13 |
| 286.33 | 2.56 | 2.56 |
| 496.52 | 2.03 | 2.03 |
| 164.25 | 2.12 | 2.12 |
| 352.42 | 2.90 | 2.90 |
| 237.31 | 3.29 | 3.29 |
| 417.26 | 3.98 | 3.98 |
| 238.70 | 3.35 | 3.35 |
| 364.36 | 3.57 | 3.57 |
| 382.89 | 2.95 | 2.95 |
| 408.46 | 2.05 | 2.05 |
| 352.42 | 3.25 | 3.25 |
| 374.40 | 1.60 | 1.60 |
| 352.42 | 3.30 | 3.30 |
| 223.32 | 2.93 | 2.93 |
| 379.81 | 3.71 | 3.71 |
| 439.39 | 3.78 | 3.78 |
| 335.41 | 3.97 | 3.97 |
| 469.52 | 3.45 | 3.45 |
| 359.46 | 3.82 | 3.82 |
| 366.51 | 4.71 | 4.71 |
| 298.73 | 3.04 | 3.04 |
| 382.46 | 3.60 | 3.60 |
| 348.40 | 3.08 | 3.08 |
| 327.38 | 2.32 | 2.32 |
| 335.36 | 3.60 | 3.60 |
| 367.33 | 5.01 | 5.01 |
| 491.52 | 5.20 | 5.20 |
| 388.38 | 4.05 | 4.05 |
| 431.90 | 5.90 | 5.90 |
| 382.42 | 4.73 | 4.73 |
| 497.65 | 6.45 | 6.45 |
| 327.39 | 4.27 | 4.27 |
| 468.63 | 5.66 | 5.66 |
| 332.32 | 3.16 | 3.16 |
| 273.34 | 2.95 | 2.95 |
| 344.23 | 4.93 | 4.93 |
| 435.87 | 3.50 | 3.50 |
| 486.57 | 4.02 | 4.02 |
| 387.48 | 3.81 | 3.81 |
| 345.45 | 3.89 | 3.89 |
| 430.53 | 4.62 | 4.62 |
| 441.47 | 4.95 | 4.95 |
| 330.48 | 2.22 | 2.22 |
| 319.37 | 2.88 | 2.88 |
| 422.49 | 3.51 | 3.51 |
| 436.55 | 3.53 | 3.53 |
| 426.29 | 3.04 | 3.04 |
| 441.47 | 4.95 | 4.95 |
| 418.45 | 2.91 | 2.91 |
| 421.53 | 2.75 | 2.75 |
| 308.37 | 3.36 | 3.36 |
| 507.50 | 6.38 | 6.38 |
| 498.46 | 5.49 | 5.49 |
| 597.90 | 6.95 | 6.95 |
| 485.61 | 5.71 | 5.71 |
| 507.59 | 4.05 | 4.05 |
| 428.56 | 4.59 | 4.59 |
| 395.44 | 3.41 | 3.41 |
| 212.27 | 2.65 | 2.65 |
| 420.45 | 4.71 | 4.71 |
| 494.04 | 4.12 | 4.12 |
| 501.61 | 4.16 | 4.16 |
| 384.39 | 4.43 | 4.43 |
| 284.72 | 1.98 | 1.98 |
| 388.45 | 1.09 | 1.09 |
| 287.32 | 1.93 | 1.93 |
| 496.03 | 4.59 | 4.59 |
| 317.40 | 3.52 | 3.52 |
| 470.53 | 3.73 | 3.73 |
| 352.42 | 2.90 | 2.90 |
| 338.45 | 4.18 | 4.18 |
| 261.35 | 3.48 | 3.48 |
| 542.59 | 3.91 | 3.91 |
| 394.40 | 4.65 | 4.65 |
| 251.35 | 4.78 | 4.78 |
| 376.83 | 2.61 | 2.61 |
| 401.53 | 4.06 | 4.06 |
| 408.41 | 2.55 | 2.55 |
| 432.72 | 3.91 | 3.91 |
| 324.43 | 2.41 | 2.41 |
| 213.24 | 2.76 | 2.76 |
| 400.49 | 4.58 | 4.58 |
| 374.40 | 0.85 | 0.85 |
| 374.40 | 4.10 | 4.10 |
| 331.42 | 4.31 | 4.31 |
| 420.49 | 3.83 | 3.83 |
| 399.45 | 4.33 | 4.33 |
| 371.42 | 3.92 | 3.92 |
| 325.78 | 1.47 | 1.47 |
| 366.43 | 2.54 | 2.54 |
| 453.55 | 3.60 | 3.60 |
| 406.41 | 2.67 | 2.67 |
| 377.44 | 3.65 | 3.65 |
| 274.32 | 4.35 | 4.35 |
| 395.48 | 4.05 | 4.05 |
| 453.45 | 2.77 | 2.77 |
| 458.97 | 3.96 | 3.96 |
| 513.53 | 2.97 | 2.97 |
| 404.43 | 2.52 | 2.52 |
| 375.50 | 3.37 | 3.37 |
| 421.54 | 2.13 | 2.13 |
| 344.41 | 3.54 | 3.54 |
| 343.36 | 3.15 | 3.15 |
| 405.82 | 3.94 | 3.94 |
| 414.56 | 4.24 | 4.24 |
| 211.26 | 2.51 | 2.51 |
| 238.34 | 2.12 | 2.12 |
| 459.51 | 2.41 | 2.41 |
| 457.54 | 3.18 | 3.18 |
| 332.36 | 3.36 | 3.36 |
| 434.52 | 4.16 | 4.16 |
| 408.80 | 3.76 | 3.76 |
| 484.56 | 4.47 | 4.47 |
| 466.60 | 4.36 | 4.36 |
| 300.34 | 0.91 | 0.91 |
| 372.45 | 1.38 | 1.38 |
| 385.47 | 3.73 | 3.73 |
| 405.46 | 3.37 | 3.37 |
| 441.51 | 2.81 | 2.81 |
| 389.41 | 2.78 | 2.78 |
| 352.31 | 3.52 | 3.52 |
| 394.39 | 0.83 | 0.83 |
| 391.42 | 1.78 | 1.78 |
| 448.86 | 4.71 | 4.71 |
| 446.56 | 3.81 | 3.81 |
| 415.45 | 3.84 | 3.84 |
| 399.48 | 2.79 | 2.79 |
| 379.49 | 3.56 | 3.56 |
| 383.47 | 3.86 | 3.86 |
| 372.38 | 2.67 | 2.67 |
| 400.55 | 5.64 | 5.64 |
| 433.90 | 2.75 | 2.75 |
| 281.41 | 2.98 | 2.98 |
| 396.54 | 4.90 | 4.90 |
| 354.39 | 3.50 | 3.50 |
| 421.43 | 2.39 | 2.39 |
| 423.65 | 3.28 | 3.28 |
| 344.42 | 0.73 | 0.73 |
| 435.87 | 3.50 | 3.50 |
| 335.30 | 1.52 | 1.52 |
| 460.63 | 3.84 | 3.84 |
| 284.31 | 4.43 | 4.43 |
| 247.32 | 2.22 | 2.22 |
| 392.46 | 2.35 | 2.35 |
| 377.44 | 3.03 | 3.03 |
| 403.57 | 2.61 | 2.61 |
| 513.54 | 4.16 | 4.16 |
| 471.51 | 4.90 | 4.90 |
| 431.32 | 3.78 | 3.78 |
| 430.92 | 4.47 | 4.47 |
| 368.34 | 2.93 | 2.93 |
| 276.80 | 2.60 | 2.60 |
| 512.87 | 5.65 | 5.65 |
| 322.46 | 3.89 | 3.89 |
| 638.53 | 5.41 | 5.41 |
| 414.09 | 7.88 | 7.88 |
| 658.75 | 1.90 | 1.90 |
| 539.33 | 5.62 | 5.62 |
| 450.56 | 3.19 | 3.19 |
| 480.52 | 2.97 | 2.97 |
| 417.49 | 4.07 | 4.07 |
| 557.59 | 4.21 | 4.21 |
| 396.06 | 3.87 | 3.87 |
| 455.31 | 4.51 | 4.51 |
| 376.89 | 5.87 | 5.87 |
| 383.54 | 3.78 | 3.78 |
| 342.87 | 5.19 | 5.19 |
| 292.43 | 0.66 | 0.66 |
| 348.74 | 2.55 | 2.55 |
| 427.73 | 6.02 | 6.02 |
| 483.68 | 4.60 | 4.60 |
| 389.86 | 3.75 | 3.75 |
| 347.39 | 2.24 | 2.24 |
| 367.53 | 3.39 | 3.39 |
| 502.57 | 3.73 | 3.73 |
| 256.26 | 2.54 | 2.54 |
| 427.73 | 6.02 | 6.02 |
| 346.32 | 1.37 | 1.37 |
| 507.63 | 2.57 | 2.57 |
| 307.31 | 3.23 | 3.23 |
| 474.04 | 5.21 | 5.21 |
| 405.46 | 4.76 | 4.76 |
| 388.43 | 3.50 | 3.50 |
| 492.33 | 4.98 | 4.98 |
| 359.18 | 2.79 | 2.79 |
| 432.41 | 4.76 | 4.76 |
| 480.91 | 3.58 | 3.58 |
| 442.43 | 4.29 | 4.29 |
| 480.59 | 4.11 | 4.11 |
| 1301.83 | ||
| 366.48 | 3.88 | 3.88 |
| 384.51 | 4.03 | 4.03 |
| 394.48 | 5.56 | 5.56 |
| 314.32 | 3.97 | 3.97 |
| 347.76 | 3.41 | 3.41 |
| 543.00 | 2.92 | 2.92 |
| 330.44 | 3.32 | 3.32 |
| 390.30 | 5.65 | 5.65 |
| 395.17 | 2.23 | 2.23 |
| 349.46 | 5.28 | 5.28 |
| 431.34 | 4.33 | 4.33 |
| 447.50 | 3.18 | 3.18 |
| 328.42 | 3.15 | 3.15 |
| 341.37 | 3.39 | 3.39 |
| 471.47 | -0.54 | -0.54 |
| 353.60 | 3.57 | 3.57 |
| 425.87 | 4.62 | 4.62 |
| 393.61 | 4.07 | 4.07 |
| 415.31 | 4.81 | 4.81 |
| 284.28 | 3.04 | 3.04 |
| 415.47 | 3.11 | 3.11 |
| 358.40 | 3.41 | 3.41 |
| 230.23 | 2.37 | 2.37 |
| 280.29 | 3.52 | 3.52 |
| 461.59 | 4.70 | 4.70 |
| 397.61 | 3.30 | 3.30 |
| 418.42 | 2.06 | 2.06 |
| 378.82 | 3.75 | 3.75 |
| 599.09 | 5.46 | 5.46 |
| 403.67 | 4.09 | 4.09 |
| 445.52 | 4.05 | 4.05 |
| 463.94 | 5.33 | 5.33 |
| 295.30 | 4.18 | 4.18 |
| 474.54 | 2.83 | 2.83 |
| 343.36 | 1.85 | 1.85 |
| 384.44 | 3.90 | 3.90 |
| 382.50 | 3.74 | 3.74 |
| 438.87 | 3.53 | 3.53 |
| 405.39 | -0.56 | -0.56 |
| 525.66 | 3.20 | 3.20 |
| 380.86 | 4.16 | 4.16 |
| 392.42 | 3.97 | 3.97 |
| 594.63 | 3.94 | 3.94 |
| 378.82 | 3.75 | 3.75 |
| 463.99 | 4.15 | 4.15 |
| 344.37 | 4.76 | 4.76 |
| 406.51 | 4.44 | 4.44 |
| 480.59 | 4.46 | 4.46 |
| 358.32 | 0.02 | 0.02 |
| 379.24 | 2.74 | 2.74 |
| 372.38 | 4.28 | 4.28 |
| 607.73 | 4.04 | 4.04 |
| 453.62 | 4.86 | 4.86 |
| 393.36 | 3.14 | 3.14 |
| 332.33 | 4.49 | 4.49 |
| 320.44 | 4.65 | 4.65 |
| 412.41 | 4.28 | 4.28 |
| 482.94 | 6.29 | 6.29 |
| 317.34 | 5.05 | 5.05 |
| 333.18 | 3.63 | 3.63 |
| 411.87 | 3.94 | 3.94 |
| 336.31 | 3.01 | 3.01 |
| 272.31 | 3.25 | 3.25 |