Basic Information
ID: ALA2020810
Type: Binding
Description: Restoration of human BSEP E297G mutant trafficking to cell membrane in MDCK2 cells co-expressing NTCP assessed as accumulation of [3H]taurocholate at 10 uM preincubated for 24 hrs prior incubation with [3H]taurocholate measured after 2 hrs by liquid scintillation counting
Organism: Homo sapiens
Cell type: MDCK2
Activity Charts
Bioactivity
Activity Types for Assay ALA2020810
Activity
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 542.85 | 8.87 | 8.87 |
| 408.58 | 3.45 | 3.45 |
| 559.83 | 7.95 | 7.95 |
| 573.86 | 7.98 | 7.98 |
| 649.96 | 9.55 | 9.55 |
| 663.99 | 9.59 | 9.59 |
| 392.58 | 4.48 | 4.48 |
| 392.58 | 4.48 | 4.48 |
| 615.94 | 9.15 | 9.15 |
| 685.99 | 10.83 | 10.83 |
| 685.99 | 10.83 | 10.83 |
| 581.07 | 8.24 | 8.24 |
| 615.51 | 8.90 | 8.90 |
| 609.12 | 8.86 | 8.86 |
| 649.96 | 9.55 | 9.55 |
| 649.96 | 9.55 | 9.55 |
| 663.99 | 9.64 | 9.64 |