Basic Information
ID: ALA2025967
Type: Functional
Description: Antagonist activity at human high sensitive and low sensitive alpha4beta2 nAChR expressed in SH-EP1 cells assessed as inhibition of carbamylcholine induced 86Rb+ ion efflux preincubated for 10 mins prior to carbamylcholine-induction measured after 5 mins by flip-plate technique relative to control
Organism: Homo sapiens
Cell type: SH-EP1
Activity Charts
Bioactivity
Activity Types for Assay ALA2025967
Efficacy
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 162.24 | 1.85 | 1.85 |
| 248.33 | 1.31 | 1.31 |
| 248.33 | 1.31 | 1.31 |
| 305.38 | 1.67 | 1.67 |
| 319.41 | 2.01 | 2.01 |
| 331.42 | 2.20 | 2.20 |
| 345.44 | 2.55 | 2.55 |
| 367.45 | 3.56 | 3.56 |
| 262.35 | 1.96 | 1.96 |
| 262.35 | 1.96 | 1.96 |
| 260.34 | 1.34 | 1.34 |