Antagonist activity at human high sensitive and low sensitive alpha4beta2 nAChR expressed in SH-EP1 cells assessed as inhibition of carbamylcholine in...

Basic Information

ID: ALA2025967

Type: Functional

Description: Antagonist activity at human high sensitive and low sensitive alpha4beta2 nAChR expressed in SH-EP1 cells assessed as inhibition of carbamylcholine induced 86Rb+ ion efflux preincubated for 10 mins prior to carbamylcholine-induction measured after 5 mins by flip-plate technique relative to control

Format: BAO_0000219

Organism: Homo sapiens

Cell type: SH-EP1

Target:  Neuronal acetylcholine receptor; alpha4/beta2(ALA1907589)

Document:  ALA2021777

Antagonist activity at human high sensitive and low sensitive alpha4beta2 nAChR expressed in SH-EP1 cells assessed as inhibition of carbamylcholine induced 86Rb+ ion efflux preincubated for 10 mins prior to carbamylcholine-induction measured after 5 mins by flip-plate technique relative to control: 1

Activity Charts

Compound Summary

Parent Molecular WeightALogPPolar Surface Area
162.241.851.85
248.331.311.31
248.331.311.31
305.381.671.67
319.412.012.01
331.422.202.20
345.442.552.55
367.453.563.56
262.351.961.96
262.351.961.96
260.341.341.34