Inhibition of human recombinant PREP expressed in Escherichia coli assessed as pNA release from Z-Gly-Pro-p-nitroanilide pre-incubated with enzyme for...

Basic Information

ID: ALA2026781

Type: Binding

Description: Inhibition of human recombinant PREP expressed in Escherichia coli assessed as pNA release from Z-Gly-Pro-p-nitroanilide pre-incubated with enzyme for 15 mins prior to substrate addition by fluorescence technique

Format: BAO_0000019

Organism: Homo sapiens

Target: Prolyl endopeptidase(ALA3202)

Document: ALA2021822

Inhibition of human recombinant PREP expressed in Escherichia coli assessed as pNA release from Z-Gly-Pro-p-nitroanilide pre-incubated with enzyme for 15 mins prior to substrate addition by fluorescence technique: 1

Associated Items: Associated Bioactivities Associated Compounds

Activity Charts

Bioactivity

Activity Types for Assay ALA2026781

IC50

Total(39)

Compound Summary

Parent Molecular Weight	ALogP	Polar Surface Area
214.07
303.41	1.17	1.17
407.32	2.02	2.02
307.35	2.08	2.08
285.35	1.25	1.25
277.35	0.92	0.92
305.76	1.51	1.51
416.31	3.76	3.76
341.29	1.83	1.83
371.44	2.26	2.26
326.18	2.24	2.24
339.42	2.66	2.66
333.39	2.60	2.60
307.35	2.08	2.08
323.37	0.49	0.49
481.55	2.30	2.30
360.39	0.85	0.85
454.48	2.58	2.58
429.50	0.88	0.88
523.58	2.61	2.61
374.35	0.85	0.85
446.51	-0.03	-0.03
331.42	1.32	1.32
298.31	1.22	1.22
348.37	2.37	2.37
348.37	2.37	2.37
325.34	2.03	2.03
293.27	1.18	1.18
343.33	2.33	2.33
271.32	1.18	1.18
319.36	2.25	2.25
335.41	2.72	2.72
375.35	2.87	2.87
271.32	1.32	1.32
321.38	2.47	2.47
339.44	2.51	2.51
257.29	0.93	0.93
287.32	0.94	0.94
237.30	0.66	0.66