Basic Information
ID: ALA2026972
Type: Binding
Description: Inhibition of full-length B-Raf V600E mutant assessed as reduction in incorporation of radiolabeled phosphate from [gamma-33P]ATP into FSBA-modified wild-type MEK.
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA2026972
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 351.38 | 3.66 | 3.66 |
| 362.40 | 4.33 | 4.33 |
| 363.39 | 3.73 | 3.73 |
| 363.39 | 3.73 | 3.73 |
| 442.29 | 4.49 | 4.49 |
| 393.42 | 3.03 | 3.03 |
| 483.54 | 4.74 | 4.74 |
| 377.42 | 3.91 | 3.91 |
| 378.40 | 3.31 | 3.31 |
| 373.44 | 1.73 | 1.73 |
| 360.41 | 3.17 | 3.17 |
| 356.45 | 3.34 | 3.34 |
| 409.42 | 2.01 | 2.01 |
| 423.45 | 2.47 | 2.47 |
| 463.51 | 3.25 | 3.25 |
| 453.47 | 1.83 | 1.83 |
| 467.50 | 2.22 | 2.22 |
| 493.54 | 3.02 | 3.02 |
| 485.52 | 4.17 | 4.17 |
| 486.50 | 3.56 | 3.56 |
| 489.51 | 2.90 | 2.90 |