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Inhibition of human CYP2C19 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 3-butyryl-7-methoxycoumarin as substrate...

Basic Information

ID: ALA2071964

Type: ADME

Description: Inhibition of human CYP2C19 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 3-butyryl-7-methoxycoumarin as substrate after 30 mins

Format: BAO_0000357

Organism: Homo sapiens

Target:  Cytochrome P450 2C19(ALA3622)

Document:  ALA2069259

Inhibition of human CYP2C19 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 3-butyryl-7-methoxycoumarin as substrate after 30 mins: 1

Activity Charts

Compound Summary

Parent Molecular WeightALogPPolar Surface Area
167.302.422.42
290.321.261.26
414.533.373.37
259.352.582.58
309.334.444.44
385.512.092.09
272.371.091.09
441.581.981.98
285.341.201.20
319.884.814.81
329.373.333.33
473.596.086.08
468.372.112.11
379.504.364.36
404.554.204.20
285.392.662.66
314.474.724.72
344.855.385.38
399.442.872.87
242.703.063.06
194.19-1.03-1.03
356.453.163.16
357.442.492.49
247.342.212.21
387.441.061.06
358.431.771.77
277.413.043.04
371.282.682.68
255.363.353.35
277.414.214.21
372.553.813.81
312.443.443.44
220.364.304.30
303.834.194.19
75.07-0.97-0.97
327.473.373.37
317.433.263.26
586.208.958.95
369.473.463.46
209.25-0.13-0.13
306.245.185.18
318.343.203.20
235.07-1.66-1.66
206.03-0.99-0.99
357.451.711.71
374.913.063.06
269.393.663.66
303.201.941.94
307.403.253.25
554.59-1.20-1.20
283.11-0.37-0.37
131.170.440.44
301.340.750.75
187.292.182.18
198.220.430.43
418.574.594.59
435.534.164.16
246.352.732.73
314.372.262.26
181.220.570.57
424.532.442.44
348.432.532.53
357.493.343.34
430.542.722.72
273.362.012.01
288.392.582.58
288.433.883.88
392.471.901.90
394.440.620.62
180.17-1.04-1.04
299.371.931.93
308.333.613.61
422.924.274.27
285.341.631.63
345.422.902.90
434.502.272.27
446.513.663.66
310.340.880.88
650.983.953.95
149.241.971.97
408.922.172.17
390.965.565.56
343.905.105.10
645.68-1.11-1.11
388.423.203.20
465.953.363.36
747.962.442.44
191.272.082.08
780.952.222.22
370.292.032.03
195.220.740.74
241.240.530.53
310.443.923.92
1209.42
149.241.841.84
254.29-0.19-0.19
167.210.770.77
332.462.852.85
1390.73
740.761.541.54