ID: ALA2071964
Type: ADME
Description: Inhibition of human CYP2C19 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 3-butyryl-7-methoxycoumarin as substrate after 30 mins
Format: BAO_0000357
Organism: Homo sapiens
Target: Cytochrome P450 2C19(ALA3622)
Document: ALA2069259
Inhibition of human CYP2C19 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 3-butyryl-7-methoxycoumarin as substrate after 30 mins: 1
Bioactivity
Activity Types for Assay ALA2071964
Inhibition
Parent Molecular Weight | ALogP | Polar Surface Area |
---|---|---|
167.30 | 2.42 | 2.42 |
290.32 | 1.26 | 1.26 |
414.53 | 3.37 | 3.37 |
259.35 | 2.58 | 2.58 |
309.33 | 4.44 | 4.44 |
385.51 | 2.09 | 2.09 |
272.37 | 1.09 | 1.09 |
441.58 | 1.98 | 1.98 |
285.34 | 1.20 | 1.20 |
319.88 | 4.81 | 4.81 |
329.37 | 3.33 | 3.33 |
473.59 | 6.08 | 6.08 |
468.37 | 2.11 | 2.11 |
379.50 | 4.36 | 4.36 |
404.55 | 4.20 | 4.20 |
285.39 | 2.66 | 2.66 |
314.47 | 4.72 | 4.72 |
344.85 | 5.38 | 5.38 |
399.44 | 2.87 | 2.87 |
242.70 | 3.06 | 3.06 |
194.19 | -1.03 | -1.03 |
356.45 | 3.16 | 3.16 |
357.44 | 2.49 | 2.49 |
247.34 | 2.21 | 2.21 |
387.44 | 1.06 | 1.06 |
358.43 | 1.77 | 1.77 |
277.41 | 3.04 | 3.04 |
371.28 | 2.68 | 2.68 |
255.36 | 3.35 | 3.35 |
277.41 | 4.21 | 4.21 |
372.55 | 3.81 | 3.81 |
312.44 | 3.44 | 3.44 |
220.36 | 4.30 | 4.30 |
303.83 | 4.19 | 4.19 |
75.07 | -0.97 | -0.97 |
327.47 | 3.37 | 3.37 |
317.43 | 3.26 | 3.26 |
586.20 | 8.95 | 8.95 |
369.47 | 3.46 | 3.46 |
209.25 | -0.13 | -0.13 |
306.24 | 5.18 | 5.18 |
318.34 | 3.20 | 3.20 |
235.07 | -1.66 | -1.66 |
206.03 | -0.99 | -0.99 |
357.45 | 1.71 | 1.71 |
374.91 | 3.06 | 3.06 |
269.39 | 3.66 | 3.66 |
303.20 | 1.94 | 1.94 |
307.40 | 3.25 | 3.25 |
554.59 | -1.20 | -1.20 |
283.11 | -0.37 | -0.37 |
131.17 | 0.44 | 0.44 |
301.34 | 0.75 | 0.75 |
187.29 | 2.18 | 2.18 |
198.22 | 0.43 | 0.43 |
418.57 | 4.59 | 4.59 |
435.53 | 4.16 | 4.16 |
246.35 | 2.73 | 2.73 |
314.37 | 2.26 | 2.26 |
181.22 | 0.57 | 0.57 |
424.53 | 2.44 | 2.44 |
348.43 | 2.53 | 2.53 |
357.49 | 3.34 | 3.34 |
430.54 | 2.72 | 2.72 |
273.36 | 2.01 | 2.01 |
288.39 | 2.58 | 2.58 |
288.43 | 3.88 | 3.88 |
392.47 | 1.90 | 1.90 |
394.44 | 0.62 | 0.62 |
180.17 | -1.04 | -1.04 |
299.37 | 1.93 | 1.93 |
308.33 | 3.61 | 3.61 |
422.92 | 4.27 | 4.27 |
285.34 | 1.63 | 1.63 |
345.42 | 2.90 | 2.90 |
434.50 | 2.27 | 2.27 |
446.51 | 3.66 | 3.66 |
310.34 | 0.88 | 0.88 |
650.98 | 3.95 | 3.95 |
149.24 | 1.97 | 1.97 |
408.92 | 2.17 | 2.17 |
390.96 | 5.56 | 5.56 |
343.90 | 5.10 | 5.10 |
645.68 | -1.11 | -1.11 |
388.42 | 3.20 | 3.20 |
465.95 | 3.36 | 3.36 |
747.96 | 2.44 | 2.44 |
191.27 | 2.08 | 2.08 |
780.95 | 2.22 | 2.22 |
370.29 | 2.03 | 2.03 |
195.22 | 0.74 | 0.74 |
241.24 | 0.53 | 0.53 |
310.44 | 3.92 | 3.92 |
1209.42 | ||
149.24 | 1.84 | 1.84 |
254.29 | -0.19 | -0.19 |
167.21 | 0.77 | 0.77 |
332.46 | 2.85 | 2.85 |
1390.73 | ||
740.76 | 1.54 | 1.54 |