Assay Report Card

Basic Information

ID: ALA2071966

Type: ADME

Description: Inhibition of human CYP3A4 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using diethoxyfluorescein as substrate after 30 mins

Organism: Homo sapiens

Activity Charts

Compound Summary

Parent Molecular WeightALogPPolar Surface Area
361.371.541.54
357.793.933.93
331.351.581.58
280.423.883.88
441.554.374.37
268.364.834.83
167.302.422.42
252.271.771.77
290.321.261.26
398.403.703.70
146.141.791.79
414.533.373.37
180.161.311.31
341.430.560.56
259.352.582.58
252.350.600.60
328.412.142.14
330.751.891.89
300.445.605.60
232.240.700.70
309.334.444.44
326.833.723.72
393.474.514.51
331.183.753.75
385.512.092.09
211.220.440.44
266.302.652.65
137.14-0.31-0.31
272.371.091.09
441.581.981.98
182.190.070.07
285.341.201.20
318.874.894.89
319.884.814.81
329.373.333.33
473.596.086.08
371.526.006.00
468.372.112.11
354.493.483.48
261.091.881.88
276.751.741.74
160.180.920.92
924.090.710.71
236.302.732.73
198.272.702.70
379.504.364.36
404.554.204.20
285.392.662.66
214.051.161.16
206.283.073.07
331.351.581.58
308.383.793.79
749.001.901.90
733.941.791.79
314.474.724.72
344.855.385.38
334.33-1.65-1.65
306.280.740.74
399.442.872.87
236.273.393.39
144.212.292.29
242.703.063.06
151.161.351.35
194.19-1.03-1.03
356.424.374.37
238.160.070.07
123.110.780.78
613.802.872.87
356.453.163.16
357.442.492.49
575.695.705.70
247.342.212.21
291.732.852.85
387.441.061.06
123.11-0.42-0.42
383.47-0.31-0.31
470.023.553.55
356.493.663.66
277.414.174.17
645.326.946.94
358.431.771.77
277.413.043.04
267.24-0.20-0.20
371.282.682.68
272.393.613.61
255.363.353.35
277.414.214.21
360.844.684.68
296.154.364.36
241.293.753.75
296.413.613.61
372.553.813.81
312.443.443.44
373.954.584.58
220.364.304.30
256.102.012.01
303.834.194.19
75.07-0.97-0.97
199.16-1.10-1.10
327.473.373.37
317.433.263.26
586.208.958.95
454.450.270.27
369.473.463.46
209.25-0.13-0.13
230.263.043.04
243.22-2.56-2.56
276.213.213.21
306.245.185.18
318.343.203.20
246.31-0.28-0.28
231.301.551.55
263.793.963.96
235.07-1.66-1.66
435.44-1.17-1.17
546.59-1.30-1.30
588.561.341.34
206.03-0.99-0.99
1202.63
357.451.711.71
374.913.063.06
269.393.663.66
543.530.000.00
303.201.941.94
307.403.253.25
246.19-1.68-1.68
404.345.505.50
554.59-1.20-1.20
283.11-0.37-0.37
131.170.440.44
308.312.762.76
301.340.750.75
296.553.623.62
187.292.182.18
198.220.430.43
224.22-0.71-0.71
277.505.305.30
248.311.681.68
418.574.594.59
435.534.164.16
334.172.892.89
365.410.020.02
246.352.732.73
136.200.690.69
238.240.960.96
179.220.720.72
314.372.262.26
181.220.570.57
424.532.442.44
348.432.532.53
153.140.670.67
324.383.493.49
357.493.343.34
374.914.044.04
372.813.143.14
317.222.452.45
324.423.173.17
531.444.214.21
430.542.722.72
251.712.902.90
273.362.012.01
288.392.582.58
288.433.883.88
152.180.640.64
822.954.344.34
392.471.901.90
457.480.190.19
444.44-0.21-0.21
424.095.465.46
394.440.620.62
180.17-1.04-1.04
470.696.416.41
299.371.931.93
236.23-0.21-0.21
308.333.613.61
136.110.060.06
337.464.224.22
422.924.274.27
558.656.316.31
408.882.272.27
285.341.631.63
346.342.182.18
345.422.902.90
434.502.272.27
446.513.663.66
170.241.381.38
310.340.880.88
277.271.151.15
650.983.953.95
1255.44
168.582.062.06
149.241.971.97
408.922.172.17
390.965.565.56
343.905.105.10
392.335.185.18
645.68-1.11-1.11
186.241.561.56
388.423.203.20
465.953.363.36
813.983.623.62
747.962.442.44
191.272.082.08
780.952.222.22
151.91
370.292.032.03
195.220.740.74
241.240.530.53
310.443.923.92
1209.42
149.241.841.84
254.29-0.19-0.19
314.261.741.74
167.210.770.77
1085.16
150.222.712.71
332.462.852.85
314.411.461.46
289.381.931.93
1390.73
740.761.541.54