Basic Information
ID: ALA2089802
Type: Functional
Description: Inhibition of CDK4/6 in human JeKo1 cells xenografted in SCID beige mouse assessed as reduction of pRb phosphorylation at 500 mg/kg/day administered BID for 2.5 days measured after 1 hr post-last dose by ELISA relative to vehicle-treated control
Format: BAO_0000218
Organism: Mus musculus
Cell type: JeKo1
Target: Mus musculus(ALA375)
Document: ALA2086364
Inhibition of CDK4/6 in human JeKo1 cells xenografted in SCID beige mouse assessed as reduction of pRb phosphorylation at 500 mg/kg/day administered BID for 2.5 days measured after 1 hr post-last dose by ELISA relative to vehicle-treated control: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA2089802
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 482.59 | 3.61 | 3.61 |