Basic Information
ID: ALA2092208
Type: Binding
Description: Inhibition of human His6-tagged recombinant FPPS expressed in Escherichia coli BL21(DE3) using GPP and [3H]IPP as substrate incubated for 5 mins prior to substrate addition measured after 20 mins by liquid scintillation counting
Format: BAO_0000019
Organism: Homo sapiens
Target: Farnesyl diphosphate synthase(ALA1782)
Document: ALA2086301
Inhibition of human His6-tagged recombinant FPPS expressed in Escherichia coli BL21(DE3) using GPP and [3H]IPP as substrate incubated for 5 mins prior to substrate addition measured after 20 mins by liquid scintillation counting: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA2092208
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 283.11 | -0.37 | -0.37 |
| 268.10 | 0.13 | 0.13 |
| 343.21 | 1.97 | 1.97 |
| 344.20 | 1.80 | 1.80 |
| 344.20 | 1.80 | 1.80 |
| 402.28 | 2.59 | 2.59 |
| 374.23 | 1.81 | 1.81 |
| 400.26 | 2.34 | 2.34 |
| 358.23 | 1.72 | 1.72 |
| 402.28 | 2.59 | 2.59 |
| 400.26 | 2.34 | 2.34 |
| 427.29 | 2.15 | 2.15 |
| 353.21 | 0.27 | 0.27 |