Basic Information
ID: ALA2114725
Type: Functional
Description: PubChem BioAssay. Dose Response confirmation of uHTS hits for small molecule antagonists of the CRF-binding protein and CRF-R2 receptor complex in 384 well format. (Class of assay: confirmatory)
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA2114725
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 340.42 | 4.39 | 4.39 |
| 286.29 | 3.17 | 3.17 |
| 322.70 | 3.21 | 3.21 |
| 402.06 | 6.67 | 6.67 |
| 319.19 | 4.45 | 4.45 |
| 399.47 | 3.47 | 3.47 |
| 275.30 | 1.97 | 1.97 |
| 440.46 | 4.81 | 4.81 |
| 324.64 | 4.10 | 4.10 |
| 297.15 | 3.86 | 3.86 |
| 338.38 | 3.47 | 3.47 |
| 452.51 | 4.22 | 4.22 |
| 483.93 | 4.08 | 4.08 |
| 318.35 | 3.58 | 3.58 |
| 394.87 | 3.24 | 3.24 |
| 298.36 | 2.47 | 2.47 |
| 392.48 | 4.83 | 4.83 |
| 421.54 | 4.26 | 4.26 |
| 257.29 | 4.05 | 4.05 |
| 348.31 | 3.22 | 3.22 |
| 394.84 | 1.98 | 1.98 |
| 374.49 | 3.91 | 3.91 |
| 454.52 | 4.96 | 4.96 |
| 514.59 | 3.08 | 3.08 |
| 482.00 | 5.84 | 5.84 |
| 411.48 | 3.04 | 3.04 |
| 446.48 | 4.99 | 4.99 |
| 462.53 | 5.54 | 5.54 |
| 440.91 | 4.74 | 4.74 |
| 220.27 | 3.26 | 3.26 |
| 472.65 | 4.83 | 4.83 |
| 318.35 | 3.34 | 3.34 |
| 397.62 | 3.75 | 3.75 |
| 285.35 | 4.01 | 4.01 |
| 357.24 | 3.55 | 3.55 |
| 410.57 | 4.12 | 4.12 |
| 429.30 | 4.08 | 4.08 |
| 497.53 | 2.91 | 2.91 |
| 275.76 | 3.21 | 3.21 |
| 326.40 | 4.58 | 4.58 |
| 305.29 | 2.34 | 2.34 |
| 368.41 | 4.05 | 4.05 |
| 379.89 | 5.45 | 5.45 |
| 460.56 | 4.91 | 4.91 |
| 342.81 | 4.82 | 4.82 |
| 394.43 | 2.28 | 2.28 |
| 470.37 | 5.04 | 5.04 |
| 326.38 | 3.82 | 3.82 |
| 380.49 | 4.41 | 4.41 |
| 574.52 | 3.17 | 3.17 |
| 376.46 | 5.72 | 5.72 |
| 379.89 | 4.70 | 4.70 |
| 435.76 | 4.93 | 4.93 |
| 522.49 | 4.69 | 4.69 |
| 412.57 | 5.35 | 5.35 |
| 408.19 | 5.02 | 5.02 |
| 518.47 | 6.22 | 6.22 |
| 383.23 | 3.68 | 3.68 |
| 316.38 | 2.98 | 2.98 |
| 325.25 | 3.33 | 3.33 |
| 289.12 | 1.92 | 1.92 |
| 386.45 | 4.28 | 4.28 |
| 308.38 | 4.79 | 4.79 |
| 473.61 | 3.43 | 3.43 |
| 342.81 | 4.65 | 4.65 |
| 407.45 | 0.46 | 0.46 |
| 340.40 | 4.26 | 4.26 |
| 449.60 | 3.59 | 3.59 |
| 408.35 | 4.99 | 4.99 |
| 261.24 | 1.90 | 1.90 |
| 344.42 | 4.06 | 4.06 |
| 354.45 | 4.69 | 4.69 |
| 407.50 | 3.41 | 3.41 |
| 399.49 | 3.59 | 3.59 |
| 400.43 | 4.13 | 4.13 |
| 388.30 | 5.43 | 5.43 |
| 306.32 | 0.98 | 0.98 |
| 361.36 | 3.97 | 3.97 |
| 333.41 | 3.42 | 3.42 |
| 341.45 | 5.79 | 5.79 |
| 288.39 | 3.05 | 3.05 |
| 232.26 | 3.14 | 3.14 |
| 441.94 | 4.51 | 4.51 |
| 425.92 | 4.35 | 4.35 |
| 338.39 | 4.04 | 4.04 |
| 376.78 | 4.19 | 4.19 |
| 419.47 | 3.89 | 3.89 |
| 302.40 | 5.08 | 5.08 |
| 507.66 | 5.61 | 5.61 |
| 358.44 | 2.94 | 2.94 |
| 365.86 | 4.88 | 4.88 |
| 526.96 | 5.45 | 5.45 |
| 460.57 | 5.66 | 5.66 |
| 481.42 | 5.50 | 5.50 |
| 397.45 | 4.41 | 4.41 |
| 339.35 | 3.41 | 3.41 |
| 410.45 | 3.53 | 3.53 |
| 332.36 | 4.38 | 4.38 |
| 402.00 | 3.73 | 3.73 |
| 406.51 | 4.70 | 4.70 |
| 388.47 | 2.73 | 2.73 |
| 426.57 | 3.52 | 3.52 |
| 309.24 | 2.98 | 2.98 |
| 480.59 | 3.12 | 3.12 |
| 443.33 | 4.38 | 4.38 |
| 373.45 | 3.40 | 3.40 |
| 376.44 | 4.18 | 4.18 |
| 333.41 | 2.84 | 2.84 |
| 353.37 | 2.89 | 2.89 |
| 273.36 | 2.99 | 2.99 |
| 531.63 | 4.36 | 4.36 |
| 446.04 | 5.33 | 5.33 |
| 353.83 | 4.67 | 4.67 |
| 344.37 | 3.32 | 3.32 |
| 415.52 | 4.19 | 4.19 |
| 476.56 | 5.30 | 5.30 |
| 489.58 | 3.57 | 3.57 |
| 320.30 | 3.52 | 3.52 |
| 397.40 | 4.79 | 4.79 |
| 321.37 | 4.04 | 4.04 |
| 411.60 | 4.88 | 4.88 |
| 406.51 | 4.17 | 4.17 |
| 430.60 | 5.12 | 5.12 |
| 336.35 | 3.44 | 3.44 |
| 306.35 | 2.43 | 2.43 |
| 364.30 | 4.99 | 4.99 |
| 297.31 | 3.33 | 3.33 |
| 417.38 | 5.77 | 5.77 |
| 400.91 | 2.86 | 2.86 |
| 425.49 | 3.36 | 3.36 |
| 344.25 | 5.42 | 5.42 |
| 464.32 | 4.76 | 4.76 |
| 411.49 | 2.79 | 2.79 |
| 425.54 | 4.41 | 4.41 |
| 384.82 | 4.36 | 4.36 |
| 340.34 | 4.66 | 4.66 |
| 301.37 | 3.94 | 3.94 |
| 430.84 | 4.36 | 4.36 |
| 400.48 | 4.64 | 4.64 |
| 363.42 | 4.64 | 4.64 |
| 362.99 | 3.96 | 3.96 |
| 407.90 | 5.30 | 5.30 |
| 330.34 | 2.82 | 2.82 |
| 384.42 | 3.28 | 3.28 |
| 425.49 | 2.13 | 2.13 |
| 504.81 | 5.06 | 5.06 |
| 468.86 | 3.55 | 3.55 |
| 366.83 | 3.61 | 3.61 |
| 324.33 | 3.18 | 3.18 |
| 304.44 | 3.03 | 3.03 |
| 324.38 | 4.06 | 4.06 |
| 328.32 | 2.97 | 2.97 |
| 405.47 | 3.54 | 3.54 |
| 419.55 | 5.36 | 5.36 |
| 440.52 | 4.61 | 4.61 |
| 272.30 | 3.52 | 3.52 |
| 325.34 | 4.04 | 4.04 |
| 407.25 | 3.86 | 3.86 |
| 293.78 | 3.86 | 3.86 |
| 562.48 | 3.30 | 3.30 |
| 466.42 | 5.82 | 5.82 |
| 411.26 | 3.30 | 3.30 |
| 411.89 | 3.72 | 3.72 |
| 458.51 | 3.28 | 3.28 |
| 518.47 | 6.22 | 6.22 |
| 328.68 | 3.50 | 3.50 |
| 297.40 | 4.89 | 4.89 |
| 341.36 | 4.50 | 4.50 |
| 478.64 | 3.68 | 3.68 |
| 337.79 | 2.72 | 2.72 |
| 386.93 | 3.63 | 3.63 |
| 302.43 | 3.64 | 3.64 |
| 242.28 | 3.52 | 3.52 |
| 432.55 | 3.35 | 3.35 |
| 197.45 | 3.35 | 3.35 |
| 418.59 | 3.70 | 3.70 |
| 472.95 | 4.49 | 4.49 |
| 423.50 | 2.56 | 2.56 |
| 340.33 | 4.43 | 4.43 |
| 377.85 | 4.06 | 4.06 |
| 327.22 | 4.47 | 4.47 |
| 415.28 | 3.77 | 3.77 |
| 314.17 | 3.88 | 3.88 |
| 389.91 | 4.69 | 4.69 |
| 536.62 | 3.02 | 3.02 |
| 365.82 | 5.21 | 5.21 |
| 236.37 | 3.71 | 3.71 |
| 551.59 | 3.90 | 3.90 |
| 416.52 | 5.53 | 5.53 |
| 490.31 | 3.81 | 3.81 |
| 299.44 | 4.42 | 4.42 |
| 369.45 | 6.01 | 6.01 |
| 380.49 | 4.32 | 4.32 |
| 347.44 | 3.47 | 3.47 |
| 338.30 | 2.30 | 2.30 |
| 480.63 | 5.58 | 5.58 |
| 266.71 | 3.79 | 3.79 |
| 423.50 | 2.56 | 2.56 |
| 429.53 | 3.12 | 3.12 |
| 464.59 | 3.50 | 3.50 |
| 420.86 | 4.84 | 4.84 |
| 378.25 | 3.46 | 3.46 |
| 278.43 | 4.17 | 4.17 |
| 393.58 | 4.38 | 4.38 |
| 317.37 | 2.85 | 2.85 |
| 385.35 | 4.80 | 4.80 |
| 315.33 | 2.46 | 2.46 |
| 388.45 | 3.28 | 3.28 |
| 342.42 | 5.48 | 5.48 |
| 444.60 | 4.23 | 4.23 |
| 233.35 | 3.38 | 3.38 |
| 374.65 | 4.20 | 4.20 |
| 390.96 | 3.06 | 3.06 |
| 337.83 | 4.55 | 4.55 |
| 380.88 | 4.01 | 4.01 |
| 471.56 | 3.11 | 3.11 |
| 443.26 | 2.67 | 2.67 |
| 350.31 | 3.82 | 3.82 |
| 495.56 | 4.79 | 4.79 |
| 345.22 | 3.04 | 3.04 |
| 384.39 | 4.43 | 4.43 |
| 313.25 | 4.30 | 4.30 |
| 413.55 | 4.05 | 4.05 |
| 350.35 | 2.74 | 2.74 |
| 232.24 | 3.11 | 3.11 |
| 425.49 | 2.13 | 2.13 |
| 388.49 | 5.49 | 5.49 |
| 346.35 | 3.99 | 3.99 |
| 399.42 | 3.23 | 3.23 |
| 243.29 | 3.26 | 3.26 |
| 361.49 | 4.16 | 4.16 |
| 342.30 | 4.20 | 4.20 |
| 338.46 | 4.45 | 4.45 |
| 316.40 | 3.07 | 3.07 |
| 413.48 | 3.92 | 3.92 |
| 287.36 | 3.63 | 3.63 |
| 317.37 | 2.75 | 2.75 |
| 408.86 | 2.37 | 2.37 |
| 393.47 | 3.82 | 3.82 |
| 422.51 | 3.12 | 3.12 |
| 429.52 | 3.22 | 3.22 |
| 365.45 | 4.32 | 4.32 |
| 252.27 | 2.59 | 2.59 |
| 298.65 | 4.00 | 4.00 |
| 443.55 | 4.36 | 4.36 |
| 417.13 | 3.49 | 3.49 |
| 453.57 | 6.15 | 6.15 |
| 392.44 | 4.06 | 4.06 |
| 479.38 | 4.32 | 4.32 |
| 312.09 | 2.79 | 2.79 |
| 401.22 | 4.80 | 4.80 |
| 276.30 | 2.81 | 2.81 |
| 474.54 | 4.63 | 4.63 |
| 301.78 | 2.79 | 2.79 |
| 330.37 | 3.38 | 3.38 |
| 350.33 | 4.35 | 4.35 |
| 301.34 | 2.51 | 2.51 |
| 429.95 | 4.44 | 4.44 |
| 455.38 | 3.54 | 3.54 |
| 350.23 | 5.48 | 5.48 |
| 300.31 | 3.29 | 3.29 |
| 330.84 | 3.81 | 3.81 |
| 303.34 | 4.15 | 4.15 |
| 492.57 | 3.00 | 3.00 |
| 497.32 | 4.79 | 4.79 |
| 394.90 | 5.05 | 5.05 |
| 442.50 | 3.98 | 3.98 |
| 401.50 | 4.73 | 4.73 |
| 441.98 | 4.38 | 4.38 |
| 392.91 | 6.24 | 6.24 |
| 364.36 | 4.02 | 4.02 |
| 294.78 | 4.38 | 4.38 |
| 330.78 | 2.37 | 2.37 |
| 479.30 | -0.32 | -0.32 |
| 401.36 | 3.45 | 3.45 |
| 458.92 | 4.18 | 4.18 |
| 395.49 | 3.86 | 3.86 |
| 378.18 | 3.03 | 3.03 |
| 380.47 | 2.71 | 2.71 |
| 470.51 | 3.30 | 3.30 |
| 407.93 | 6.05 | 6.05 |
| 244.28 | 2.88 | 2.88 |
| 273.27 | 2.78 | 2.78 |
| 518.47 | 6.22 | 6.22 |
| 397.44 | 2.26 | 2.26 |
| 349.81 | 5.14 | 5.14 |
| 396.40 | 3.71 | 3.71 |
| 441.00 | 6.09 | 6.09 |
| 281.31 | 2.66 | 2.66 |
| 411.50 | 4.28 | 4.28 |
| 405.47 | 3.73 | 3.73 |
| 345.44 | 4.49 | 4.49 |
| 289.29 | 0.34 | 0.34 |
| 581.20 | 6.12 | 6.12 |
| 346.39 | 4.44 | 4.44 |
| 369.23 | 3.37 | 3.37 |
| 290.20 | 3.48 | 3.48 |
| 312.73 | 3.05 | 3.05 |
| 512.94 | 4.69 | 4.69 |
| 212.25 | 2.49 | 2.49 |
| 326.76 | 3.36 | 3.36 |
| 242.28 | 3.23 | 3.23 |
| 296.33 | 2.49 | 2.49 |
| 445.52 | 2.96 | 2.96 |
| 342.38 | 3.86 | 3.86 |
| 606.73 | 6.04 | 6.04 |
| 476.64 | 5.05 | 5.05 |
| 329.46 | 3.60 | 3.60 |
| 387.37 | 3.77 | 3.77 |
| 427.57 | 5.01 | 5.01 |
| 440.44 | 3.87 | 3.87 |
| 391.54 | 3.20 | 3.20 |
| 260.21 | 2.88 | 2.88 |
| 439.55 | 4.64 | 4.64 |
| 435.35 | 4.38 | 4.38 |
| 581.20 | 6.10 | 6.10 |
| 441.47 | 3.44 | 3.44 |
| 266.30 | 2.08 | 2.08 |
| 408.54 | 6.12 | 6.12 |
| 450.44 | 4.33 | 4.33 |
| 372.47 | 4.79 | 4.79 |
| 576.78 | 5.48 | 5.48 |
| 514.52 | 3.95 | 3.95 |
| 267.78 | 4.38 | 4.38 |
| 385.46 | 3.96 | 3.96 |
| 359.43 | 3.68 | 3.68 |
| 427.57 | 3.07 | 3.07 |
| 378.30 | 2.46 | 2.46 |
| 245.23 | 1.89 | 1.89 |
| 309.15 | 3.72 | 3.72 |
| 358.47 | 5.59 | 5.59 |
| 338.66 | 3.81 | 3.81 |
| 299.38 | 4.59 | 4.59 |
| 416.47 | 3.86 | 3.86 |
| 362.50 | 4.97 | 4.97 |
| 393.49 | 2.83 | 2.83 |
| 461.58 | 5.50 | 5.50 |
| 278.35 | 3.57 | 3.57 |
| 454.48 | 5.61 | 5.61 |
| 354.35 | 3.98 | 3.98 |
| 284.36 | 3.10 | 3.10 |
| 308.26 | 3.85 | 3.85 |
| 408.43 | 4.27 | 4.27 |
| 324.30 | 2.78 | 2.78 |
| 276.22 | 3.33 | 3.33 |
| 473.57 | 2.24 | 2.24 |
| 318.79 | 3.67 | 3.67 |
| 402.06 | 6.67 | 6.67 |
| 389.45 | 3.80 | 3.80 |
| 498.00 | 1.83 | 1.83 |
| 283.72 | 3.51 | 3.51 |
| 453.37 | 4.68 | 4.68 |
| 277.63 | 2.99 | 2.99 |
| 537.68 | 5.95 | 5.95 |
| 336.37 | 4.03 | 4.03 |
| 451.39 | 3.85 | 3.85 |
| 373.66 | 4.02 | 4.02 |
| 356.92 | 4.69 | 4.69 |
| 353.38 | 1.42 | 1.42 |
| 363.87 | 4.38 | 4.38 |
| 351.27 | 3.73 | 3.73 |
| 399.49 | 4.46 | 4.46 |
| 440.46 | 3.38 | 3.38 |
| 355.44 | 4.72 | 4.72 |
| 388.50 | 4.23 | 4.23 |
| 333.34 | 4.38 | 4.38 |
| 397.36 | 3.56 | 3.56 |
| 431.25 | 4.31 | 4.31 |
| 350.42 | 3.90 | 3.90 |
| 319.36 | 3.32 | 3.32 |
| 336.34 | 4.34 | 4.34 |
| 396.36 | 3.04 | 3.04 |
| 503.01 | 4.09 | 4.09 |