Basic Information
ID: ALA2114742
Type: Functional
Description: PubChem BioAssay. Dose response confirmation of small molecule inhibitors of the catalytic domain of the SUMO protease, SENP1 in a kinetic FRET assay. (Class of assay: confirmatory)
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA2114742
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 328.37 | 2.12 | 2.12 |
| 249.29 | 2.61 | 2.61 |
| 402.55 | 4.20 | 4.20 |
| 582.60 | -0.14 | -0.14 |
| 271.28 | 0.94 | 0.94 |
| 354.41 | 2.85 | 2.85 |
| 309.76 | 3.99 | 3.99 |
| 378.40 | 2.66 | 2.66 |
| 248.24 | 0.73 | 0.73 |
| 278.29 | -0.01 | -0.01 |
| 334.38 | 4.37 | 4.37 |
| 320.35 | 1.86 | 1.86 |
| 332.43 | 2.50 | 2.50 |
| 368.50 | 3.85 | 3.85 |
| 401.50 | 3.93 | 3.93 |
| 408.26 | 4.81 | 4.81 |
| 355.35 | 3.30 | 3.30 |
| 300.36 | 2.95 | 2.95 |
| 273.30 | 3.32 | 3.32 |
| 390.46 | 2.65 | 2.65 |
| 526.64 | 3.70 | 3.70 |
| 353.25 | 3.44 | 3.44 |
| 377.83 | 2.93 | 2.93 |
| 380.79 | 3.31 | 3.31 |
| 321.38 | 4.13 | 4.13 |
| 340.43 | 3.29 | 3.29 |
| 462.64 | 5.12 | 5.12 |
| 425.29 | 3.61 | 3.61 |
| 226.23 | 2.61 | 2.61 |
| 395.84 | 5.18 | 5.18 |
| 419.39 | 4.06 | 4.06 |
| 398.48 | 4.22 | 4.22 |
| 411.28 | 3.04 | 3.04 |
| 319.39 | 4.43 | 4.43 |
| 390.44 | 2.53 | 2.53 |
| 324.25 | 1.56 | 1.56 |
| 337.40 | 3.86 | 3.86 |
| 251.74 | 4.47 | 4.47 |
| 308.39 | 2.78 | 2.78 |
| 316.76 | 4.71 | 4.71 |
| 387.48 | 3.93 | 3.93 |
| 306.37 | 2.62 | 2.62 |
| 260.23 | 3.05 | 3.05 |
| 403.51 | 3.65 | 3.65 |
| 543.60 | 4.56 | 4.56 |
| 196.21 | 2.94 | 2.94 |
| 340.39 | 4.04 | 4.04 |
| 289.73 | 2.84 | 2.84 |
| 294.33 | 3.61 | 3.61 |
| 494.62 | 3.36 | 3.36 |
| 433.54 | 2.51 | 2.51 |
| 413.48 | 5.20 | 5.20 |
| 419.44 | 2.79 | 2.79 |
| 244.30 | 4.34 | 4.34 |
| 399.45 | 4.81 | 4.81 |
| 246.27 | 1.04 | 1.04 |
| 324.37 | 3.13 | 3.13 |
| 265.25 | 0.65 | 0.65 |
| 296.37 | 4.04 | 4.04 |
| 410.43 | 4.35 | 4.35 |
| 333.17 | 3.86 | 3.86 |
| 340.38 | 3.68 | 3.68 |
| 278.29 | -0.01 | -0.01 |
| 229.24 | 2.92 | 2.92 |
| 452.89 | 3.10 | 3.10 |
| 283.24 | 2.92 | 2.92 |
| 439.90 | 3.96 | 3.96 |
| 436.54 | 2.89 | 2.89 |
| 327.43 | 4.05 | 4.05 |
| 320.22 | 3.79 | 3.79 |
| 268.27 | 2.33 | 2.33 |
| 332.33 | 4.01 | 4.01 |
| 323.31 | 2.75 | 2.75 |
| 367.62 | 5.08 | 5.08 |
| 457.65 | 5.42 | 5.42 |
| 264.31 | 2.36 | 2.36 |
| 202.17 | 1.18 | 1.18 |
| 472.59 | 3.11 | 3.11 |
| 325.39 | 4.35 | 4.35 |
| 329.45 | 1.05 | 1.05 |
| 306.73 | 3.16 | 3.16 |
| 223.25 | 0.69 | 0.69 |
| 336.78 | 5.28 | 5.28 |
| 413.43 | 3.73 | 3.73 |
| 284.13 | 2.19 | 2.19 |
| 404.49 | 4.29 | 4.29 |
| 371.23 | 4.05 | 4.05 |
| 257.25 | 1.66 | 1.66 |
| 245.35 | 4.45 | 4.45 |
| 419.44 | 2.79 | 2.79 |
| 292.25 | -0.29 | -0.29 |
| 275.29 | 1.16 | 1.16 |
| 451.57 | 5.25 | 5.25 |
| 274.32 | 4.35 | 4.35 |
| 358.82 | 4.59 | 4.59 |
| 419.48 | 3.61 | 3.61 |
| 440.29 | 5.29 | 5.29 |
| 294.35 | 3.44 | 3.44 |
| 380.45 | 4.32 | 4.32 |
| 274.32 | 4.35 | 4.35 |
| 419.30 | 4.64 | 4.64 |
| 245.32 | 0.43 | 0.43 |
| 353.76 | 3.98 | 3.98 |
| 323.78 | 4.98 | 4.98 |
| 342.35 | 3.65 | 3.65 |
| 343.39 | 1.94 | 1.94 |
| 488.04 | 4.76 | 4.76 |
| 397.38 | 4.78 | 4.78 |
| 427.50 | 5.59 | 5.59 |
| 404.52 | 4.70 | 4.70 |
| 424.88 | 3.18 | 3.18 |
| 414.44 | 2.46 | 2.46 |
| 443.55 | 4.01 | 4.01 |
| 320.40 | 2.93 | 2.93 |
| 327.41 | 2.81 | 2.81 |
| 377.15 | 3.55 | 3.55 |
| 401.54 | 5.35 | 5.35 |
| 436.49 | 3.09 | 3.09 |
| 342.78 | 4.30 | 4.30 |
| 460.88 | 3.10 | 3.10 |
| 333.21 | 5.23 | 5.23 |
| 379.44 | 4.33 | 4.33 |
| 304.28 | 1.13 | 1.13 |
| 412.47 | 1.82 | 1.82 |
| 447.56 | 3.15 | 3.15 |
| 471.61 | 3.85 | 3.85 |
| 314.34 | 3.95 | 3.95 |
| 430.48 | 1.28 | 1.28 |
| 585.56 | 5.60 | 5.60 |
| 255.23 | 2.38 | 2.38 |
| 241.25 | 3.04 | 3.04 |
| 403.42 | 1.68 | 1.68 |
| 594.52 | -1.39 | -1.39 |
| 362.43 | 1.76 | 1.76 |
| 296.37 | 4.11 | 4.11 |
| 351.32 | 3.52 | 3.52 |
| 456.52 | 1.81 | 1.81 |
| 209.25 | 2.61 | 2.61 |
| 316.20 | 2.64 | 2.64 |
| 445.52 | 4.00 | 4.00 |
| 374.87 | 3.85 | 3.85 |
| 387.23 | 3.03 | 3.03 |
| 314.41 | 3.09 | 3.09 |
| 398.47 | 4.51 | 4.51 |
| 213.21 | 2.62 | 2.62 |
| 432.38 | -1.16 | -1.16 |
| 385.69 | 3.96 | 3.96 |
| 231.22 | 1.89 | 1.89 |
| 340.42 | 3.19 | 3.19 |
| 426.49 | 4.27 | 4.27 |
| 326.47 | 4.17 | 4.17 |
| 411.81 | 6.14 | 6.14 |
| 359.48 | 3.80 | 3.80 |
| 577.44 | 3.58 | 3.58 |
| 524.60 | 3.79 | 3.79 |
| 377.44 | 5.19 | 5.19 |
| 345.24 | 2.65 | 2.65 |
| 354.37 | 3.19 | 3.19 |
| 332.37 | 3.26 | 3.26 |
| 210.20 | 2.11 | 2.11 |
| 456.27 | 6.25 | 6.25 |
| 334.38 | 3.33 | 3.33 |
| 368.40 | 3.75 | 3.75 |
| 425.54 | 4.38 | 4.38 |
| 343.43 | 4.77 | 4.77 |
| 372.47 | 5.38 | 5.38 |
| 392.48 | 4.42 | 4.42 |
| 424.48 | 2.43 | 2.43 |
| 392.44 | 4.03 | 4.03 |
| 375.45 | 4.75 | 4.75 |
| 254.25 | 1.73 | 1.73 |
| 292.30 | 2.77 | 2.77 |
| 311.41 | 2.44 | 2.44 |
| 340.40 | 3.05 | 3.05 |
| 254.31 | 0.59 | 0.59 |
| 341.31 | 3.06 | 3.06 |
| 416.53 | 4.00 | 4.00 |