Basic Information
ID: ALA2114749
Type: Functional
Description: PubChem BioAssay. Counterscreen for inhibitors of Trypanosoma brucei methionyl tRNA synthetase (MetRS): Luminescence-based cell-based high throughput dose response assay to identify compounds that are cytotoxic to Jurkat human T lymphocyte cells. (Class of assay: confirmatory)
Organism: Homo sapiens
Cell type: Jurkat
Activity Charts
Bioactivity
Activity Types for Assay ALA2114749
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 416.13 | 6.45 | 6.45 |
| 479.15 | 6.45 | 6.45 |
| 209.25 | 2.66 | 2.66 |
| 345.83 | 2.90 | 2.90 |
| 350.78 | 3.11 | 3.11 |
| 271.11 | 2.74 | 2.74 |
| 424.31 | 4.25 | 4.25 |
| 338.32 | 3.04 | 3.04 |
| 448.94 | 5.09 | 5.09 |
| 323.40 | 2.46 | 2.46 |
| 321.83 | 4.56 | 4.56 |
| 361.24 | 3.52 | 3.52 |
| 446.33 | 5.91 | 5.91 |
| 379.40 | 2.92 | 2.92 |
| 309.37 | 3.67 | 3.67 |
| 420.88 | 2.06 | 2.06 |
| 451.31 | 5.68 | 5.68 |
| 347.21 | 3.24 | 3.24 |
| 417.86 | 4.42 | 4.42 |
| 513.39 | 2.78 | 2.78 |
| 351.41 | 4.59 | 4.59 |
| 417.90 | 4.47 | 4.47 |
| 358.76 | 3.29 | 3.29 |
| 385.45 | 1.67 | 1.67 |
| 439.33 | 2.65 | 2.65 |
| 398.87 | 3.11 | 3.11 |
| 346.82 | 4.96 | 4.96 |
| 393.47 | 3.18 | 3.18 |
| 449.55 | 4.18 | 4.18 |
| 508.44 | 5.02 | 5.02 |
| 396.27 | 4.01 | 4.01 |
| 394.43 | 2.14 | 2.14 |
| 431.90 | 4.79 | 4.79 |
| 308.17 | 4.19 | 4.19 |
| 433.51 | 3.54 | 3.54 |
| 435.48 | 2.74 | 2.74 |
| 386.76 | 1.90 | 1.90 |
| 407.43 | 2.28 | 2.28 |
| 500.39 | 4.14 | 4.14 |
| 362.81 | 2.97 | 2.97 |
| 474.42 | 4.23 | 4.23 |
| 465.51 | 3.11 | 3.11 |
| 493.61 | 4.14 | 4.14 |
| 549.63 | 4.43 | 4.43 |
| 371.36 | 5.21 | 5.21 |
| 610.52 | -2.42 | -2.42 |
| 295.30 | 1.68 | 1.68 |
| 350.80 | 2.91 | 2.91 |
| 363.45 | 3.17 | 3.17 |
| 397.35 | 3.44 | 3.44 |
| 429.52 | 3.22 | 3.22 |
| 548.44 | 5.06 | 5.06 |
| 475.59 | 4.72 | 4.72 |
| 411.26 | 4.59 | 4.59 |
| 363.20 | 4.81 | 4.81 |
| 427.33 | 5.06 | 5.06 |
| 385.40 | 3.14 | 3.14 |
| 412.96 | 5.17 | 5.17 |
| 341.82 | 4.67 | 4.67 |
| 423.74 | 3.47 | 3.47 |
| 371.77 | 4.69 | 4.69 |
| 469.54 | 4.30 | 4.30 |
| 331.33 | 2.16 | 2.16 |
| 479.59 | 3.80 | 3.80 |
| 411.31 | 2.50 | 2.50 |
| 412.27 | 4.34 | 4.34 |
| 359.86 | 4.00 | 4.00 |
| 348.24 | 4.56 | 4.56 |
| 412.34 | 4.94 | 4.94 |
| 433.51 | 3.54 | 3.54 |
| 429.33 | 3.20 | 3.20 |
| 393.85 | 3.61 | 3.61 |
| 324.43 | 4.45 | 4.45 |
| 430.96 | 5.03 | 5.03 |
| 432.51 | 4.44 | 4.44 |
| 344.76 | 3.10 | 3.10 |
| 361.47 | 2.98 | 2.98 |
| 386.92 | 5.55 | 5.55 |
| 434.45 | 2.14 | 2.14 |
| 476.53 | 3.58 | 3.58 |
| 409.47 | 2.88 | 2.88 |
| 458.58 | 2.56 | 2.56 |
| 365.89 | 5.93 | 5.93 |
| 451.32 | 4.59 | 4.59 |
| 414.49 | 2.02 | 2.02 |
| 399.93 | 4.09 | 4.09 |
| 513.55 | 4.03 | 4.03 |
| 317.27 | 4.54 | 4.54 |
| 377.47 | 4.65 | 4.65 |
| 480.59 | 5.13 | 5.13 |
| 401.47 | 3.02 | 3.02 |
| 491.34 | 5.11 | 5.11 |
| 394.48 | 3.42 | 3.42 |
| 517.36 | 6.34 | 6.34 |
| 443.57 | 3.96 | 3.96 |
| 310.28 | 3.17 | 3.17 |
| 459.55 | 3.61 | 3.61 |
| 393.27 | 3.41 | 3.41 |
| 401.51 | 3.26 | 3.26 |
| 346.82 | 4.96 | 4.96 |
| 397.46 | 4.14 | 4.14 |
| 351.32 | 2.63 | 2.63 |
| 382.65 | 3.50 | 3.50 |
| 338.21 | 4.10 | 4.10 |
| 416.69 | 4.99 | 4.99 |
| 360.24 | 3.84 | 3.84 |
| 354.21 | 3.88 | 3.88 |
| 348.41 | 4.00 | 4.00 |
| 296.29 | 2.58 | 2.58 |
| 436.54 | 2.89 | 2.89 |
| 415.49 | 2.83 | 2.83 |
| 379.45 | 3.51 | 3.51 |
| 344.37 | 3.90 | 3.90 |
| 304.37 | 3.88 | 3.88 |
| 372.43 | 2.64 | 2.64 |
| 485.57 | 4.87 | 4.87 |
| 352.84 | 2.77 | 2.77 |
| 436.32 | 3.11 | 3.11 |
| 423.95 | 3.53 | 3.53 |
| 378.22 | 3.18 | 3.18 |
| 451.31 | 5.68 | 5.68 |
| 336.91 | 4.56 | 4.56 |
| 389.84 | 5.29 | 5.29 |
| 431.90 | 4.79 | 4.79 |
| 371.42 | 4.98 | 4.98 |
| 397.44 | 3.01 | 3.01 |
| 455.38 | 5.03 | 5.03 |
| 469.37 | 5.00 | 5.00 |
| 377.26 | 5.21 | 5.21 |
| 411.53 | 3.08 | 3.08 |
| 328.35 | 2.37 | 2.37 |
| 342.43 | 4.79 | 4.79 |
| 318.83 | 4.53 | 4.53 |
| 525.63 | 5.52 | 5.52 |
| 409.43 | 2.97 | 2.97 |
| 491.34 | 5.11 | 5.11 |
| 371.85 | 3.78 | 3.78 |
| 477.59 | 4.60 | 4.60 |
| 399.88 | 3.61 | 3.61 |
| 484.60 | 3.53 | 3.53 |
| 286.35 | 3.97 | 3.97 |
| 395.68 | 4.25 | 4.25 |
| 486.55 | 4.02 | 4.02 |
| 445.37 | 5.18 | 5.18 |
| 369.79 | 3.28 | 3.28 |
| 343.82 | 3.19 | 3.19 |
| 383.81 | 2.89 | 2.89 |
| 406.28 | 2.97 | 2.97 |
| 414.81 | 2.54 | 2.54 |
| 323.40 | 2.84 | 2.84 |
| 414.90 | 3.76 | 3.76 |
| 343.43 | 4.97 | 4.97 |
| 381.44 | 3.31 | 3.31 |
| 390.92 | 5.27 | 5.27 |
| 384.83 | 5.29 | 5.29 |
| 534.16 | 5.27 | 5.27 |
| 466.35 | 3.50 | 3.50 |
| 333.80 | 3.74 | 3.74 |
| 419.28 | 4.65 | 4.65 |
| 415.49 | 2.83 | 2.83 |
| 349.27 | 4.39 | 4.39 |
| 286.35 | 3.97 | 3.97 |
| 324.61 | 4.28 | 4.28 |
| 234.28 | 2.26 | 2.26 |
| 378.84 | 3.95 | 3.95 |
| 359.45 | 3.51 | 3.51 |
| 361.79 | 3.27 | 3.27 |
| 441.55 | 3.09 | 3.09 |
| 390.40 | 2.39 | 2.39 |
| 429.52 | 3.22 | 3.22 |
| 417.26 | 2.85 | 2.85 |
| 407.47 | 3.15 | 3.15 |
| 379.45 | 2.87 | 2.87 |
| 513.54 | 4.16 | 4.16 |
| 264.67 | 2.15 | 2.15 |
| 465.35 | 4.84 | 4.84 |
| 416.42 | 1.68 | 1.68 |
| 309.20 | 4.36 | 4.36 |
| 352.31 | 1.25 | 1.25 |
| 513.36 | 3.73 | 3.73 |
| 357.37 | 3.74 | 3.74 |
| 530.67 | 4.61 | 4.61 |
| 333.22 | 4.77 | 4.77 |
| 542.27 | 5.98 | 5.98 |
| 370.73 | 4.97 | 4.97 |
| 349.22 | 4.47 | 4.47 |
| 459.42 | 3.34 | 3.34 |
| 339.40 | 3.19 | 3.19 |
| 337.18 | 4.60 | 4.60 |
| 387.19 | 5.48 | 5.48 |
| 337.18 | 4.60 | 4.60 |
| 458.39 | 4.41 | 4.41 |
| 365.26 | 3.94 | 3.94 |
| 361.23 | 3.89 | 3.89 |
| 545.45 | 4.52 | 4.52 |
| 405.52 | 3.46 | 3.46 |
| 508.00 | 4.92 | 4.92 |
| 427.55 | 3.80 | 3.80 |
| 406.43 | 5.05 | 5.05 |
| 487.43 | 5.31 | 5.31 |
| 337.18 | 4.60 | 4.60 |
| 437.97 | 4.15 | 4.15 |
| 349.22 | 4.47 | 4.47 |
| 373.89 | 1.95 | 1.95 |
| 397.88 | 1.63 | 1.63 |
| 353.64 | 5.12 | 5.12 |
| 402.21 | 3.50 | 3.50 |
| 360.45 | 3.71 | 3.71 |
| 393.83 | 3.44 | 3.44 |
| 334.81 | 4.97 | 4.97 |
| 352.80 | 5.10 | 5.10 |
| 372.88 | 4.68 | 4.68 |
| 351.23 | 4.30 | 4.30 |
| 289.34 | 3.80 | 3.80 |
| 312.16 | 2.85 | 2.85 |
| 275.31 | 3.49 | 3.49 |
| 392.21 | 3.89 | 3.89 |
| 511.00 | 3.87 | 3.87 |
| 459.25 | 3.84 | 3.84 |
| 514.42 | 4.39 | 4.39 |
| 448.39 | 3.81 | 3.81 |
| 447.54 | 3.22 | 3.22 |
| 457.12 | 3.75 | 3.75 |
| 333.22 | 4.77 | 4.77 |
| 361.25 | 2.89 | 2.89 |
| 421.82 | 2.48 | 2.48 |
| 342.48 | 4.95 | 4.95 |
| 436.30 | 2.98 | 2.98 |
| 345.30 | 3.81 | 3.81 |
| 430.35 | 4.25 | 4.25 |
| 282.30 | 2.72 | 2.72 |
| 406.24 | 2.99 | 2.99 |
| 346.37 | 2.53 | 2.53 |
| 294.31 | 3.13 | 3.13 |
| 360.85 | 5.28 | 5.28 |
| 341.19 | 3.90 | 3.90 |
| 299.40 | 3.02 | 3.02 |
| 381.78 | 1.34 | 1.34 |
| 365.22 | 3.85 | 3.85 |
| 347.76 | 3.78 | 3.78 |
| 326.36 | 3.03 | 3.03 |
| 314.41 | 3.33 | 3.33 |
| 295.30 | 2.38 | 2.38 |
| 349.23 | 3.65 | 3.65 |
| 361.37 | 2.20 | 2.20 |
| 315.76 | 2.82 | 2.82 |
| 366.20 | 3.18 | 3.18 |
| 450.80 | 5.01 | 5.01 |
| 460.22 | 4.78 | 4.78 |