Basic Information
ID: ALA2114761
Type: Functional
Description: PubChem BioAssay. Dose response confirmation of small molecule inhibitors of Low Molecular Weight Protein Tyrosine Phosphatase, LMPTP, in an orthogonal absorbance-based assay. (Class of assay: confirmatory)
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA2114761
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 248.72 | 2.52 | 2.52 |
| 733.94 | 1.79 | 1.79 |
| 395.42 | -0.17 | -0.17 |
| 289.73 | 3.47 | 3.47 |
| 318.81 | 3.12 | 3.12 |
| 317.35 | 1.15 | 1.15 |
| 493.55 | 3.65 | 3.65 |
| 289.38 | 4.65 | 4.65 |
| 312.38 | 4.30 | 4.30 |
| 438.44 | 0.74 | 0.74 |
| 268.14 | 3.58 | 3.58 |
| 344.75 | 3.96 | 3.96 |
| 551.65 | 6.32 | 6.32 |
| 388.84 | 3.23 | 3.23 |
| 290.25 | 3.79 | 3.79 |
| 467.53 | 2.65 | 2.65 |
| 494.62 | 3.45 | 3.45 |
| 310.40 | 1.25 | 1.25 |
| 472.96 | 2.68 | 2.68 |
| 367.29 | 4.39 | 4.39 |
| 290.25 | 2.92 | 2.92 |
| 346.18 | 3.12 | 3.12 |
| 592.12 | 4.26 | 4.26 |
| 338.45 | 3.82 | 3.82 |
| 318.59 | 4.33 | 4.33 |
| 282.35 | 1.64 | 1.64 |
| 393.42 | 4.56 | 4.56 |
| 256.35 | 3.49 | 3.49 |
| 458.57 | 4.17 | 4.17 |
| 425.54 | 3.27 | 3.27 |
| 319.38 | 2.91 | 2.91 |
| 410.52 | 4.53 | 4.53 |
| 518.52 | 2.97 | 2.97 |
| 471.86 | 6.57 | 6.57 |
| 516.98 | 3.35 | 3.35 |
| 326.74 | 2.88 | 2.88 |
| 382.43 | 3.18 | 3.18 |
| 512.56 | 2.70 | 2.70 |
| 471.50 | 2.88 | 2.88 |
| 399.50 | 2.74 | 2.74 |
| 459.96 | 5.20 | 5.20 |
| 572.57 | 4.05 | 4.05 |
| 542.59 | 2.71 | 2.71 |
| 414.44 | 5.03 | 5.03 |
| 381.84 | 4.18 | 4.18 |
| 361.43 | 3.83 | 3.83 |
| 319.36 | 4.03 | 4.03 |
| 452.54 | 2.66 | 2.66 |
| 386.47 | 2.98 | 2.98 |
| 302.38 | 3.28 | 3.28 |
| 421.46 | 4.54 | 4.54 |
| 316.41 | 4.28 | 4.28 |
| 276.30 | 3.89 | 3.89 |
| 515.57 | 3.26 | 3.26 |
| 278.27 | 2.76 | 2.76 |
| 151.23 | 1.51 | 1.51 |
| 374.23 | 4.34 | 4.34 |
| 380.30 | 4.43 | 4.43 |
| 433.46 | 4.86 | 4.86 |
| 230.27 | 1.85 | 1.85 |
| 439.48 | 2.89 | 2.89 |
| 496.56 | 3.00 | 3.00 |
| 306.34 | 3.11 | 3.11 |
| 359.36 | 1.43 | 1.43 |
| 318.79 | 4.01 | 4.01 |
| 301.39 | 4.40 | 4.40 |
| 357.89 | 4.52 | 4.52 |
| 387.44 | 3.33 | 3.33 |
| 381.39 | 4.36 | 4.36 |
| 278.26 | 3.91 | 3.91 |
| 264.33 | 4.30 | 4.30 |
| 459.58 | 4.17 | 4.17 |
| 470.48 | 5.25 | 5.25 |
| 480.48 | 2.23 | 2.23 |
| 371.87 | 4.35 | 4.35 |
| 346.44 | 2.73 | 2.73 |
| 375.18 | 2.15 | 2.15 |
| 500.53 | 2.83 | 2.83 |
| 307.76 | 3.94 | 3.94 |
| 413.43 | 3.57 | 3.57 |
| 411.39 | 1.85 | 1.85 |
| 329.34 | 3.32 | 3.32 |
| 389.21 | 4.07 | 4.07 |
| 524.62 | 4.18 | 4.18 |
| 407.43 | 3.98 | 3.98 |
| 496.56 | 3.00 | 3.00 |
| 348.45 | 3.43 | 3.43 |
| 386.37 | 4.65 | 4.65 |
| 328.78 | 3.70 | 3.70 |
| 337.31 | 3.81 | 3.81 |
| 510.58 | 2.21 | 2.21 |
| 329.41 | 4.00 | 4.00 |
| 370.41 | 3.96 | 3.96 |
| 279.30 | 2.64 | 2.64 |
| 410.43 | 2.46 | 2.46 |
| 284.15 | 2.12 | 2.12 |
| 314.34 | 3.59 | 3.59 |
| 418.43 | 1.31 | 1.31 |
| 527.00 | 3.30 | 3.30 |
| 341.37 | 3.21 | 3.21 |
| 390.79 | 4.41 | 4.41 |
| 512.97 | 2.92 | 2.92 |
| 351.26 | 5.03 | 5.03 |
| 288.39 | 4.89 | 4.89 |
| 326.40 | 4.61 | 4.61 |
| 450.49 | 5.24 | 5.24 |
| 338.39 | 3.79 | 3.79 |
| 293.35 | 3.76 | 3.76 |
| 435.18 | 3.86 | 3.86 |
| 415.45 | 4.01 | 4.01 |
| 325.41 | 2.85 | 2.85 |
| 356.41 | 1.25 | 1.25 |
| 490.92 | 5.86 | 5.86 |
| 355.44 | 4.75 | 4.75 |
| 343.86 | 4.14 | 4.14 |
| 371.37 | 3.79 | 3.79 |
| 409.54 | 3.59 | 3.59 |
| 546.56 | 3.37 | 3.37 |
| 292.29 | 4.22 | 4.22 |
| 428.46 | 3.97 | 3.97 |
| 446.94 | 4.27 | 4.27 |
| 336.58 | 4.21 | 4.21 |
| 482.54 | 2.70 | 2.70 |
| 370.41 | 3.96 | 3.96 |
| 381.51 | 4.54 | 4.54 |
| 433.46 | 4.86 | 4.86 |
| 405.87 | 6.01 | 6.01 |
| 406.54 | 5.10 | 5.10 |
| 396.50 | 4.28 | 4.28 |
| 303.39 | 3.35 | 3.35 |
| 229.24 | 1.56 | 1.56 |
| 435.48 | 5.14 | 5.14 |
| 423.43 | 5.24 | 5.24 |
| 322.36 | 3.15 | 3.15 |
| 402.45 | 3.64 | 3.64 |
| 486.36 | 4.87 | 4.87 |
| 500.53 | 2.83 | 2.83 |
| 466.52 | 1.35 | 1.35 |
| 410.43 | 3.71 | 3.71 |
| 430.84 | 4.39 | 4.39 |
| 343.41 | 5.61 | 5.61 |
| 403.42 | 2.84 | 2.84 |
| 338.39 | 3.18 | 3.18 |
| 460.54 | 3.57 | 3.57 |
| 376.51 | 4.73 | 4.73 |
| 498.61 | 4.19 | 4.19 |
| 366.44 | 3.57 | 3.57 |
| 561.43 | 3.46 | 3.46 |
| 360.82 | 3.56 | 3.56 |
| 286.76 | 3.99 | 3.99 |
| 359.34 | 3.87 | 3.87 |
| 535.41 | 2.65 | 2.65 |
| 500.53 | 2.83 | 2.83 |
| 358.44 | 2.56 | 2.56 |
| 380.35 | 3.77 | 3.77 |
| 348.45 | 3.35 | 3.35 |
| 472.50 | 4.92 | 4.92 |
| 309.76 | 3.64 | 3.64 |
| 331.79 | 3.90 | 3.90 |
| 385.51 | 3.99 | 3.99 |
| 382.38 | 2.83 | 2.83 |
| 345.34 | 1.12 | 1.12 |
| 303.77 | 3.40 | 3.40 |
| 342.42 | 2.04 | 2.04 |
| 474.49 | 4.20 | 4.20 |
| 376.32 | 4.21 | 4.21 |
| 325.42 | 5.47 | 5.47 |
| 386.52 | 4.99 | 4.99 |
| 422.40 | 3.29 | 3.29 |
| 484.55 | 3.61 | 3.61 |
| 363.33 | 2.77 | 2.77 |
| 278.33 | 2.57 | 2.57 |
| 308.41 | 3.34 | 3.34 |
| 456.50 | 3.34 | 3.34 |
| 344.39 | 1.15 | 1.15 |
| 337.40 | 3.31 | 3.31 |
| 444.47 | 4.80 | 4.80 |
| 369.38 | 3.25 | 3.25 |
| 431.45 | 2.29 | 2.29 |
| 333.44 | 3.21 | 3.21 |
| 431.52 | 4.90 | 4.90 |
| 459.89 | 3.35 | 3.35 |
| 362.34 | 4.76 | 4.76 |
| 362.48 | 3.74 | 3.74 |
| 441.58 | 5.12 | 5.12 |
| 432.32 | 3.96 | 3.96 |
| 348.45 | 3.95 | 3.95 |
| 275.29 | 2.63 | 2.63 |
| 429.54 | 2.41 | 2.41 |
| 458.47 | 4.53 | 4.53 |
| 425.45 | 2.70 | 2.70 |
| 417.47 | 3.33 | 3.33 |
| 561.43 | 3.46 | 3.46 |
| 421.52 | 3.97 | 3.97 |
| 469.50 | 2.90 | 2.90 |
| 322.80 | 3.62 | 3.62 |
| 371.44 | 4.93 | 4.93 |
| 433.47 | 5.34 | 5.34 |
| 355.42 | 4.03 | 4.03 |
| 363.46 | 4.67 | 4.67 |
| 440.31 | 6.66 | 6.66 |
| 436.36 | 4.36 | 4.36 |
| 386.83 | 4.66 | 4.66 |
| 396.45 | 1.58 | 1.58 |
| 284.34 | 4.31 | 4.31 |
| 307.37 | 4.79 | 4.79 |
| 421.45 | 3.25 | 3.25 |
| 438.46 | 3.21 | 3.21 |
| 412.93 | 5.14 | 5.14 |
| 405.26 | 4.71 | 4.71 |
| 353.40 | 2.50 | 2.50 |
| 348.38 | 4.92 | 4.92 |
| 407.34 | 3.40 | 3.40 |
| 295.46 | 3.51 | 3.51 |
| 542.59 | 2.71 | 2.71 |
| 370.50 | 3.12 | 3.12 |
| 234.11 | 2.89 | 2.89 |
| 329.32 | 3.62 | 3.62 |
| 529.55 | 2.46 | 2.46 |
| 353.40 | 3.89 | 3.89 |
| 481.56 | 2.70 | 2.70 |
| 446.58 | 5.01 | 5.01 |
| 264.28 | 3.48 | 3.48 |
| 346.39 | ||
| 396.83 | 5.49 | 5.49 |
| 343.45 | 5.32 | 5.32 |
| 380.53 | 4.79 | 4.79 |
| 302.38 | 4.20 | 4.20 |
| 324.34 | 2.79 | 2.79 |
| 282.26 | 2.99 | 2.99 |
| 386.37 | 4.65 | 4.65 |
| 320.35 | 2.85 | 2.85 |
| 524.62 | 2.98 | 2.98 |
| 517.54 | 2.14 | 2.14 |
| 328.88 | 2.52 | 2.52 |
| 371.47 | 3.79 | 3.79 |
| 241.32 | 1.93 | 1.93 |
| 337.38 | 3.51 | 3.51 |
| 245.24 | 1.52 | 1.52 |
| 203.20 | 1.29 | 1.29 |
| 371.44 | 3.77 | 3.77 |
| 331.46 | 4.80 | 4.80 |
| 496.55 | 1.36 | 1.36 |
| 399.86 | 3.47 | 3.47 |
| 667.82 | 6.00 | 6.00 |
| 370.50 | 5.52 | 5.52 |
| 425.37 | 3.40 | 3.40 |
| 520.63 | 2.21 | 2.21 |
| 485.61 | 3.94 | 3.94 |
| 511.38 | 4.03 | 4.03 |
| 429.51 | 5.71 | 5.71 |
| 411.49 | 4.03 | 4.03 |
| 433.54 | 4.88 | 4.88 |
| 411.26 | 3.84 | 3.84 |
| 292.43 | 0.66 | 0.66 |
| 356.50 | 4.49 | 4.49 |
| 389.86 | 3.75 | 3.75 |
| 466.58 | 4.95 | 4.95 |
| 370.48 | 4.14 | 4.14 |
| 324.77 | 3.57 | 3.57 |
| 333.37 | 2.50 | 2.50 |
| 375.45 | 2.52 | 2.52 |
| 398.51 | 5.13 | 5.13 |
| 201.25 | 2.17 | 2.17 |
| 232.29 | 4.18 | 4.18 |
| 330.42 | 2.46 | 2.46 |
| 231.90 | 2.69 | 2.69 |
| 428.47 | 4.39 | 4.39 |
| 359.22 | 3.99 | 3.99 |
| 388.43 | 3.50 | 3.50 |
| 340.39 | 2.14 | 2.14 |
| 328.75 | 3.41 | 3.41 |
| 612.15 | 5.86 | 5.86 |
| 496.37 | 4.37 | 4.37 |
| 373.76 | 3.30 | 3.30 |
| 434.41 | 3.08 | 3.08 |
| 387.44 | 3.73 | 3.73 |
| 354.19 | 3.18 | 3.18 |
| 434.41 | 3.08 | 3.08 |
| 348.16 | 3.12 | 3.12 |
| 418.42 | 2.06 | 2.06 |
| 336.35 | 3.11 | 3.11 |
| 403.67 | 4.09 | 4.09 |
| 605.67 | 4.14 | 4.14 |
| 368.39 | 3.87 | 3.87 |
| 389.41 | 3.17 | 3.17 |
| 594.63 | 3.94 | 3.94 |
| 323.31 | 1.48 | 1.48 |
| 374.19 | 3.75 | 3.75 |
| 416.40 | 4.16 | 4.16 |
| 407.09 | 3.05 | 3.05 |
| 416.46 | 4.03 | 4.03 |
| 181.19 | 0.50 | 0.50 |
| 506.59 | 2.54 | 2.54 |
| 524.60 | 2.14 | 2.14 |
| 392.49 | 4.02 | 4.02 |
| 392.42 | 3.77 | 3.77 |
| 409.54 | 4.94 | 4.94 |
| 365.46 | 2.07 | 2.07 |
| 486.53 | 3.44 | 3.44 |
| 418.54 | 4.06 | 4.06 |
| 481.60 | 4.99 | 4.99 |
| 577.71 | 5.21 | 5.21 |
| 374.47 | 3.38 | 3.38 |
| 367.48 | 4.08 | 4.08 |
| 371.47 | 3.32 | 3.32 |
| 395.43 | 4.36 | 4.36 |
| 178.20 | 0.44 | 0.44 |
| 595.70 | 5.35 | 5.35 |
| 271.36 | 3.56 | 3.56 |
| 454.57 | 4.57 | 4.57 |
| 277.32 | 1.96 | 1.96 |
| 296.33 | 3.56 | 3.56 |
| 504.68 | 6.13 | 6.13 |
| 342.47 | 3.98 | 3.98 |
| 367.79 | 3.95 | 3.95 |
| 382.06 | 3.98 | 3.98 |
| 358.35 | 4.05 | 4.05 |
| 393.81 | 3.70 | 3.70 |
| 366.33 | 3.02 | 3.02 |
| 354.19 | 3.18 | 3.18 |
| 357.78 | 2.85 | 2.85 |
| 338.44 | 3.07 | 3.07 |
| 319.34 | 2.82 | 2.82 |
| 340.38 | 5.02 | 5.02 |
| 384.84 | 4.38 | 4.38 |
| 438.24 | 5.01 | 5.01 |
| 373.21 | 3.61 | 3.61 |
| 359.34 | 4.26 | 4.26 |
| 468.26 | 3.56 | 3.56 |
| 333.18 | 4.03 | 4.03 |
| 411.47 | 3.80 | 3.80 |
| 363.35 | 3.20 | 3.20 |
| 377.38 | 3.51 | 3.51 |
| 510.02 | 3.52 | 3.52 |
| 465.45 | 1.78 | 1.78 |
| 343.22 | 4.27 | 4.27 |
| 424.25 | 3.83 | 3.83 |