Basic Information
ID: ALA2114811
Type: Functional
Description: PubChem BioAssay. Acumen qHTS Assay for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells: Hit Validation. (Class of assay: confirmatory)
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA2114811
Potency
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 238.29 | 3.12 | 3.12 |
| 393.44 | 3.41 | 3.41 |
| 267.24 | -0.20 | -0.20 |
| 475.36 | 4.43 | 4.43 |
| 485.95 | 4.39 | 4.39 |
| 563.65 | 6.00 | 6.00 |
| 478.66 | 5.04 | 5.04 |
| 585.70 | 2.54 | 2.54 |
| 491.07 | 5.09 | 5.09 |
| 356.18 | 5.18 | 5.18 |
| 488.02 | 3.31 | 3.31 |
| 466.54 | 4.35 | 4.35 |
| 408.55 | 3.16 | 3.16 |
| 589.72 | 4.59 | 4.59 |
| 426.56 | 4.97 | 4.97 |
| 266.09 | -1.08 | -1.08 |
| 395.52 | 5.78 | 5.78 |
| 588.48 | 6.89 | 6.89 |
| 513.38 | 5.79 | 5.79 |
| 406.76 | 5.17 | 5.17 |
| 375.86 | 5.50 | 5.50 |
| 421.54 | 4.20 | 4.20 |
| 439.47 | 3.47 | 3.47 |
| 371.46 | 2.64 | 2.64 |
| 323.37 | 4.72 | 4.72 |
| 441.58 | 4.53 | 4.53 |
| 463.41 | 4.15 | 4.15 |
| 396.54 | 3.01 | 3.01 |
| 408.55 | 3.16 | 3.16 |
| 367.49 | 3.86 | 3.86 |
| 637.04 | 5.55 | 5.55 |
| 456.44 | 2.88 | 2.88 |
| 325.36 | 3.68 | 3.68 |
| 443.29 | 5.15 | 5.15 |
| 420.26 | 3.71 | 3.71 |
| 338.84 | 5.44 | 5.44 |
| 414.29 | 4.96 | 4.96 |
| 381.46 | 3.30 | 3.30 |
| 386.52 | 6.00 | 6.00 |
| 481.57 | 5.21 | 5.21 |
| 425.46 | 4.97 | 4.97 |
| 399.23 | 6.05 | 6.05 |
| 415.54 | 3.49 | 3.49 |
| 407.99 | 3.40 | 3.40 |
| 372.42 | 4.72 | 4.72 |
| 460.00 | 4.18 | 4.18 |
| 416.39 | 4.33 | 4.33 |
| 416.64 | 4.31 | 4.31 |
| 437.93 | 3.08 | 3.08 |
| 404.55 | 4.94 | 4.94 |
| 479.53 | 4.68 | 4.68 |
| 454.50 | 2.83 | 2.83 |
| 469.95 | 5.74 | 5.74 |
| 437.42 | 5.82 | 5.82 |
| 447.60 | 4.88 | 4.88 |
| 447.59 | 3.11 | 3.11 |
| 450.56 | 5.15 | 5.15 |
| 410.32 | 5.17 | 5.17 |
| 384.93 | 6.01 | 6.01 |
| 477.36 | 5.06 | 5.06 |
| 440.63 | 6.51 | 6.51 |
| 392.33 | 3.45 | 3.45 |
| 636.24 | 6.33 | 6.33 |
| 406.36 | 5.34 | 5.34 |
| 273.73 | 2.70 | 2.70 |
| 366.45 | 3.59 | 3.59 |
| 477.30 | 4.34 | 4.34 |
| 389.45 | 4.47 | 4.47 |
| 407.47 | 4.83 | 4.83 |
| 469.03 | 4.45 | 4.45 |
| 423.58 | 4.93 | 4.93 |
| 492.07 | 4.88 | 4.88 |
| 377.49 | 5.31 | 5.31 |
| 436.58 | 5.26 | 5.26 |
| 331.36 | 2.12 | 2.12 |
| 507.43 | 4.87 | 4.87 |
| 421.50 | 5.34 | 5.34 |
| 486.52 | 5.67 | 5.67 |
| 480.96 | 2.61 | 2.61 |
| 494.53 | 4.36 | 4.36 |
| 400.46 | 1.89 | 1.89 |
| 441.98 | 5.79 | 5.79 |
| 393.19 | 3.87 | 3.87 |
| 416.32 | 4.23 | 4.23 |
| 372.53 | 4.73 | 4.73 |
| 466.33 | 4.20 | 4.20 |
| 432.57 | 3.65 | 3.65 |
| 560.68 | 5.43 | 5.43 |
| 380.45 | 4.06 | 4.06 |
| 369.23 | 3.13 | 3.13 |
| 357.41 | 4.88 | 4.88 |
| 430.34 | 4.62 | 4.62 |
| 411.93 | 4.45 | 4.45 |
| 353.42 | 3.91 | 3.91 |
| 424.91 | 4.45 | 4.45 |
| 404.36 | 4.62 | 4.62 |
| 390.30 | 4.66 | 4.66 |
| 466.46 | 4.88 | 4.88 |
| 455.38 | 5.62 | 5.62 |
| 433.51 | 5.45 | 5.45 |
| 449.48 | 5.89 | 5.89 |
| 446.59 | 5.17 | 5.17 |
| 570.57 | 5.50 | 5.50 |
| 459.51 | 5.21 | 5.21 |
| 407.51 | 3.81 | 3.81 |
| 486.96 | 3.83 | 3.83 |
| 376.51 | 3.58 | 3.58 |
| 374.48 | 5.35 | 5.35 |
| 348.45 | 4.13 | 4.13 |
| 492.62 | 5.15 | 5.15 |
| 419.87 | 4.27 | 4.27 |
| 325.78 | 2.09 | 2.09 |
| 460.56 | 3.74 | 3.74 |
| 289.34 | 3.94 | 3.94 |
| 439.99 | 5.23 | 5.23 |
| 385.22 | 4.06 | 4.06 |
| 419.48 | 5.00 | 5.00 |
| 321.42 | 4.27 | 4.27 |
| 423.90 | 4.97 | 4.97 |
| 424.55 | 2.86 | 2.86 |
| 411.53 | 3.81 | 3.81 |
| 429.91 | 5.22 | 5.22 |
| 403.87 | 4.94 | 4.94 |
| 509.45 | 4.36 | 4.36 |
| 427.96 | 4.65 | 4.65 |
| 338.21 | 4.70 | 4.70 |
| 454.96 | 2.66 | 2.66 |
| 421.93 | 3.85 | 3.85 |
| 437.51 | 4.20 | 4.20 |
| 407.42 | 5.10 | 5.10 |
| 431.94 | 3.49 | 3.49 |
| 421.49 | 5.03 | 5.03 |
| 448.59 | 4.79 | 4.79 |
| 377.44 | 5.30 | 5.30 |
| 505.66 | 3.59 | 3.59 |
| 418.52 | 5.01 | 5.01 |
| 440.33 | 6.56 | 6.56 |
| 432.39 | 4.80 | 4.80 |
| 470.96 | 3.56 | 3.56 |
| 409.49 | 4.88 | 4.88 |
| 421.50 | 4.45 | 4.45 |
| 446.51 | 4.84 | 4.84 |
| 378.54 | 6.05 | 6.05 |
| 387.44 | 3.70 | 3.70 |
| 431.51 | 4.76 | 4.76 |
| 463.99 | 6.06 | 6.06 |
| 392.52 | 5.24 | 5.24 |
| 338.21 | 4.40 | 4.40 |
| 463.58 | 4.45 | 4.45 |
| 464.50 | 4.38 | 4.38 |
| 392.57 | 5.64 | 5.64 |
| 357.80 | 3.88 | 3.88 |
| 455.54 | 4.23 | 4.23 |
| 497.43 | 4.00 | 4.00 |
| 489.06 | 5.06 | 5.06 |
| 416.48 | 3.84 | 3.84 |
| 384.39 | 3.63 | 3.63 |
| 309.37 | 3.51 | 3.51 |
| 424.50 | 4.48 | 4.48 |
| 390.46 | 2.17 | 2.17 |
| 402.45 | 5.33 | 5.33 |
| 415.49 | 5.25 | 5.25 |
| 339.82 | 5.24 | 5.24 |
| 402.41 | 4.46 | 4.46 |
| 431.90 | 3.39 | 3.39 |
| 485.99 | 4.01 | 4.01 |
| 498.35 | 6.19 | 6.19 |
| 339.80 | 1.85 | 1.85 |
| 451.55 | 3.86 | 3.86 |
| 403.94 | 3.71 | 3.71 |
| 462.89 | 3.45 | 3.45 |
| 347.32 | 5.17 | 5.17 |
| 485.54 | 4.60 | 4.60 |
| 401.88 | 3.03 | 3.03 |
| 403.87 | 4.66 | 4.66 |
| 429.48 | 4.91 | 4.91 |
| 420.54 | 5.37 | 5.37 |
| 412.53 | 4.04 | 4.04 |
| 352.42 | 3.28 | 3.28 |
| 421.54 | 5.48 | 5.48 |
| 317.39 | 5.26 | 5.26 |
| 427.48 | 5.97 | 5.97 |
| 578.58 | 3.46 | 3.46 |
| 419.87 | 3.17 | 3.17 |
| 477.61 | 2.95 | 2.95 |
| 400.53 | 3.06 | 3.06 |
| 424.50 | 4.25 | 4.25 |
| 423.97 | 5.35 | 5.35 |
| 384.46 | 4.42 | 4.42 |
| 379.50 | 4.59 | 4.59 |
| 532.62 | 4.65 | 4.65 |
| 395.43 | 3.11 | 3.11 |
| 501.65 | 4.76 | 4.76 |
| 437.59 | 4.56 | 4.56 |
| 424.91 | 3.46 | 3.46 |
| 384.93 | 6.01 | 6.01 |
| 579.72 | 4.35 | 4.35 |
| 494.98 | 3.00 | 3.00 |
| 517.41 | -0.14 | -0.14 |
| 408.55 | 3.16 | 3.16 |
| 388.42 | 4.83 | 4.83 |
| 407.50 | 4.30 | 4.30 |
| 462.55 | 5.51 | 5.51 |
| 460.44 | 5.43 | 5.43 |
| 455.51 | 4.59 | 4.59 |
| 494.98 | 3.00 | 3.00 |
| 324.38 | 3.59 | 3.59 |
| 450.33 | 4.76 | 4.76 |
| 469.51 | 5.96 | 5.96 |
| 339.44 | 3.81 | 3.81 |
| 423.83 | 3.63 | 3.63 |
| 385.42 | 5.56 | 5.56 |
| 526.61 | 5.75 | 5.75 |
| 328.44 | 3.45 | 3.45 |
| 452.51 | 4.26 | 4.26 |
| 438.94 | 5.50 | 5.50 |
| 396.49 | 4.88 | 4.88 |
| 287.75 | 3.01 | 3.01 |
| 447.49 | 5.20 | 5.20 |
| 429.33 | 2.54 | 2.54 |
| 387.48 | 2.85 | 2.85 |
| 416.48 | 3.59 | 3.59 |
| 433.89 | 4.11 | 4.11 |
| 416.57 | 5.08 | 5.08 |
| 430.66 | 4.70 | 4.70 |
| 451.50 | 5.09 | 5.09 |
| 344.21 | 3.80 | 3.80 |
| 328.76 | 2.82 | 2.82 |
| 408.91 | 6.19 | 6.19 |
| 430.46 | 3.93 | 3.93 |
| 431.32 | 4.31 | 4.31 |
| 429.57 | 3.88 | 3.88 |
| 438.94 | 4.23 | 4.23 |
| 405.52 | 4.39 | 4.39 |
| 402.88 | 4.91 | 4.91 |
| 301.52 | 4.15 | 4.15 |
| 351.45 | 4.73 | 4.73 |
| 426.54 | 4.31 | 4.31 |
| 396.43 | 5.08 | 5.08 |
| 402.23 | 3.64 | 3.64 |
| 392.86 | 4.10 | 4.10 |
| 378.47 | 4.93 | 4.93 |
| 380.51 | 4.80 | 4.80 |
| 325.78 | 2.18 | 2.18 |
| 377.51 | 3.75 | 3.75 |
| 438.94 | 2.28 | 2.28 |
| 420.49 | 4.70 | 4.70 |
| 404.49 | 4.75 | 4.75 |
| 379.53 | 5.41 | 5.41 |
| 339.82 | 5.24 | 5.24 |
| 436.58 | 4.48 | 4.48 |
| 278.36 | 4.05 | 4.05 |
| 417.98 | 5.79 | 5.79 |
| 459.91 | 3.45 | 3.45 |
| 453.56 | 3.69 | 3.69 |
| 448.54 | 3.74 | 3.74 |
| 474.95 | 3.97 | 3.97 |
| 432.61 | 3.89 | 3.89 |
| 492.62 | 3.10 | 3.10 |
| 456.98 | 2.87 | 2.87 |
| 412.54 | 5.27 | 5.27 |
| 488.61 | 4.99 | 4.99 |
| 358.51 | 3.95 | 3.95 |
| 339.82 | 5.24 | 5.24 |
| 358.44 | 3.70 | 3.70 |
| 457.49 | 4.99 | 4.99 |
| 376.41 | 4.90 | 4.90 |
| 504.99 | 4.48 | 4.48 |
| 391.47 | 5.65 | 5.65 |
| 480.90 | 5.36 | 5.36 |
| 422.51 | 3.37 | 3.37 |
| 513.62 | 7.18 | 7.18 |
| 425.39 | 5.95 | 5.95 |
| 306.36 | 1.58 | 1.58 |
| 343.82 | 3.99 | 3.99 |
| 576.65 | 4.60 | 4.60 |
| 352.42 | 4.22 | 4.22 |
| 478.53 | 4.52 | 4.52 |
| 528.12 | 4.61 | 4.61 |
| 449.50 | 5.42 | 5.42 |
| 445.93 | 3.78 | 3.78 |
| 324.45 | 4.74 | 4.74 |
| 320.39 | 4.48 | 4.48 |
| 372.49 | 5.96 | 5.96 |
| 540.69 | 2.74 | 2.74 |
| 399.49 | 4.56 | 4.56 |
| 343.39 | 4.76 | 4.76 |
| 405.89 | 5.52 | 5.52 |
| 415.49 | 3.56 | 3.56 |
| 573.98 | 5.03 | 5.03 |
| 499.95 | 4.69 | 4.69 |
| 477.75 | 7.32 | 7.32 |
| 458.91 | 5.98 | 5.98 |
| 368.50 | 4.94 | 4.94 |
| 450.54 | 4.55 | 4.55 |
| 431.90 | 3.67 | 3.67 |
| 363.46 | 4.76 | 4.76 |
| 417.48 | 4.37 | 4.37 |
| 424.91 | 1.89 | 1.89 |
| 497.47 | 4.50 | 4.50 |
| 459.91 | 3.53 | 3.53 |
| 427.46 | 0.34 | 0.34 |
| 354.41 | 3.72 | 3.72 |
| 441.89 | 3.63 | 3.63 |
| 360.26 | 3.78 | 3.78 |
| 566.12 | 5.19 | 5.19 |
| 401.51 | 3.24 | 3.24 |
| 423.95 | 3.78 | 3.78 |
| 333.46 | 5.73 | 5.73 |
| 383.26 | 3.44 | 3.44 |
| 445.93 | 3.78 | 3.78 |
| 370.91 | 5.62 | 5.62 |
| 388.51 | 5.66 | 5.66 |
| 349.37 | 2.71 | 2.71 |
| 581.76 | 3.62 | 3.62 |
| 474.33 | 3.87 | 3.87 |
| 445.56 | 5.45 | 5.45 |
| 454.55 | 3.58 | 3.58 |
| 488.98 | 4.28 | 4.28 |
| 426.58 | 4.54 | 4.54 |
| 462.60 | 5.75 | 5.75 |
| 494.54 | 5.00 | 5.00 |
| 357.48 | 4.10 | 4.10 |
| 491.86 | 4.89 | 4.89 |
| 452.49 | 3.97 | 3.97 |
| 434.58 | 5.03 | 5.03 |
| 530.70 | 4.83 | 4.83 |
| 528.72 | 4.19 | 4.19 |
| 430.66 | 4.70 | 4.70 |
| 577.50 | 5.39 | 5.39 |
| 386.93 | 3.90 | 3.90 |
| 441.48 | 4.02 | 4.02 |
| 576.67 | 4.79 | 4.79 |
| 483.01 | 3.95 | 3.95 |
| 463.39 | 4.86 | 4.86 |
| 460.97 | 3.97 | 3.97 |
| 431.49 | 4.02 | 4.02 |
| 483.04 | 3.45 | 3.45 |
| 463.99 | 6.69 | 6.69 |
| 424.53 | 4.86 | 4.86 |
| 471.54 | 4.93 | 4.93 |
| 448.59 | 5.77 | 5.77 |
| 445.91 | 2.54 | 2.54 |
| 604.66 | 4.43 | 4.43 |
| 430.80 | 4.01 | 4.01 |
| 383.52 | 6.68 | 6.68 |
| 485.33 | 3.19 | 3.19 |
| 396.43 | 5.08 | 5.08 |
| 385.89 | 5.38 | 5.38 |
| 451.57 | 2.42 | 2.42 |
| 369.54 | 4.28 | 4.28 |
| 434.58 | 5.03 | 5.03 |
| 389.43 | 4.14 | 4.14 |
| 350.42 | 4.07 | 4.07 |
| 386.46 | 4.58 | 4.58 |
| 472.59 | 4.71 | 4.71 |
| 468.41 | 4.38 | 4.38 |
| 477.59 | 5.76 | 5.76 |
| 488.58 | 5.50 | 5.50 |
| 436.51 | 4.34 | 4.34 |
| 493.51 | 4.86 | 4.86 |
| 407.47 | 4.72 | 4.72 |
| 424.30 | 5.53 | 5.53 |
| 423.48 | 3.95 | 3.95 |
| 428.53 | 5.95 | 5.95 |
| 467.54 | 5.66 | 5.66 |
| 417.42 | 5.04 | 5.04 |
| 430.55 | 4.20 | 4.20 |
| 429.52 | 3.95 | 3.95 |
| 482.01 | 4.97 | 4.97 |
| 362.78 | 6.14 | 6.14 |
| 419.89 | 3.36 | 3.36 |
| 382.49 | 3.87 | 3.87 |
| 489.63 | 5.57 | 5.57 |
| 551.65 | 4.94 | 4.94 |
| 365.50 | 4.95 | 4.95 |
| 498.95 | 4.56 | 4.56 |
| 477.87 | 5.28 | 5.28 |
| 437.42 | 5.82 | 5.82 |
| 457.00 | 4.82 | 4.82 |
| 352.39 | 4.00 | 4.00 |
| 402.47 | 4.25 | 4.25 |
| 465.89 | 3.51 | 3.51 |
| 409.46 | 3.50 | 3.50 |
| 317.40 | 3.65 | 3.65 |
| 324.34 | 2.25 | 2.25 |
| 473.53 | 5.56 | 5.56 |
| 539.65 | 4.52 | 4.52 |
| 385.46 | 4.31 | 4.31 |
| 426.92 | 3.54 | 3.54 |
| 369.83 | 1.86 | 1.86 |
| 451.96 | 3.64 | 3.64 |
| 305.38 | 4.58 | 4.58 |
| 480.50 | 3.97 | 3.97 |
| 417.82 | 4.09 | 4.09 |
| 338.48 | 5.21 | 5.21 |
| 420.97 | 6.23 | 6.23 |
| 326.36 | 2.98 | 2.98 |
| 343.43 | 4.79 | 4.79 |
| 399.45 | 5.33 | 5.33 |
| 361.35 | 5.47 | 5.47 |
| 540.66 | 5.17 | 5.17 |
| 301.33 | 2.40 | 2.40 |
| 386.25 | 2.60 | 2.60 |
| 393.87 | 5.25 | 5.25 |
| 399.88 | 3.74 | 3.74 |
| 467.57 | 3.70 | 3.70 |
| 397.54 | 3.90 | 3.90 |
| 506.93 | 5.93 | 5.93 |
| 446.60 | 5.37 | 5.37 |
| 443.83 | 5.15 | 5.15 |
| 354.48 | 4.45 | 4.45 |
| 345.40 | 4.73 | 4.73 |
| 351.45 | 4.03 | 4.03 |
| 347.80 | 4.49 | 4.49 |
| 395.53 | 5.19 | 5.19 |
| 380.42 | 3.67 | 3.67 |
| 347.46 | 4.79 | 4.79 |
| 448.95 | 5.31 | 5.31 |
| 401.60 | 3.43 | 3.43 |
| 498.03 | 5.65 | 5.65 |
| 416.64 | 4.31 | 4.31 |
| 290.36 | 1.88 | 1.88 |
| 392.91 | 3.37 | 3.37 |
| 462.98 | 3.95 | 3.95 |
| 432.31 | 4.67 | 4.67 |
| 382.49 | 4.10 | 4.10 |
| 309.41 | 3.89 | 3.89 |
| 379.41 | 3.96 | 3.96 |
| 360.87 | 5.77 | 5.77 |
| 387.94 | 4.47 | 4.47 |
| 469.01 | 3.41 | 3.41 |
| 457.55 | 4.09 | 4.09 |
| 400.82 | 4.21 | 4.21 |
| 397.43 | 5.37 | 5.37 |
| 429.38 | 6.12 | 6.12 |
| 470.98 | 4.34 | 4.34 |
| 407.42 | 5.10 | 5.10 |
| 302.40 | 2.93 | 2.93 |
| 411.53 | 3.81 | 3.81 |
| 468.64 | 3.69 | 3.69 |
| 434.56 | 5.46 | 5.46 |
| 375.39 | 5.12 | 5.12 |
| 420.92 | 4.52 | 4.52 |
| 442.94 | 5.59 | 5.59 |
| 486.50 | 3.78 | 3.78 |
| 356.40 | 5.00 | 5.00 |
| 406.53 | 6.03 | 6.03 |
| 496.94 | 5.22 | 5.22 |
| 412.51 | 5.39 | 5.39 |
| 369.47 | 4.78 | 4.78 |
| 451.96 | 3.64 | 3.64 |
| 433.94 | 4.95 | 4.95 |
| 306.36 | 1.66 | 1.66 |
| 335.41 | 3.70 | 3.70 |
| 319.40 | 4.74 | 4.74 |
| 429.57 | 3.78 | 3.78 |
| 375.47 | 4.74 | 4.74 |
| 358.51 | 3.85 | 3.85 |
| 371.57 | 3.66 | 3.66 |
| 448.49 | 4.83 | 4.83 |
| 407.56 | 3.18 | 3.18 |
| 341.36 | 2.95 | 2.95 |
| 265.31 | 3.03 | 3.03 |
| 439.31 | 3.79 | 3.79 |
| 465.34 | 4.40 | 4.40 |
| 392.57 | 6.30 | 6.30 |
| 447.00 | 4.91 | 4.91 |
| 444.00 | 4.43 | 4.43 |
| 387.57 | 3.40 | 3.40 |
| 383.46 | 5.11 | 5.11 |
| 467.55 | 4.28 | 4.28 |
| 434.87 | 3.48 | 3.48 |
| 337.42 | 3.47 | 3.47 |
| 542.50 | 4.81 | 4.81 |
| 428.28 | 1.60 | 1.60 |
| 416.57 | 4.35 | 4.35 |
| 329.74 | 2.79 | 2.79 |
| 443.46 | 2.89 | 2.89 |
| 360.42 | 3.59 | 3.59 |
| 555.61 | 3.39 | 3.39 |
| 394.91 | 4.06 | 4.06 |
| 331.39 | 3.08 | 3.08 |
| 438.51 | 2.98 | 2.98 |