Basic Information
ID: ALA2114842
Type: Functional
Description: PubChem BioAssay. qHTS assay for small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway. (Class of assay: confirmatory)
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA2114842
Potency
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 162.24 | 1.85 | 1.85 |
| 357.79 | 3.93 | 3.93 |
| 391.56 | 6.86 | 6.86 |
| 268.36 | 4.83 | 4.83 |
| 216.19 | 2.55 | 2.55 |
| 180.16 | 1.31 | 1.31 |
| 270.24 | 2.58 | 2.58 |
| 248.72 | 2.52 | 2.52 |
| 303.14 | 3.61 | 3.61 |
| 232.28 | 1.86 | 1.86 |
| 254.24 | 2.87 | 2.87 |
| 108.10 | 0.25 | 0.25 |
| 224.17 | 0.41 | 0.41 |
| 282.47 | 6.11 | 6.11 |
| 286.42 | 4.09 | 4.09 |
| 228.32 | 3.50 | 3.50 |
| 109.13 | 0.97 | 0.97 |
| 387.52 | 5.70 | 5.70 |
| 292.21 | 2.32 | 2.32 |
| 406.91 | 6.61 | 6.61 |
| 305.50 | 3.20 | 3.20 |
| 924.09 | 0.71 | 0.71 |
| 404.55 | 4.20 | 4.20 |
| 102.16 | -0.54 | -0.54 |
| 184.11 | 1.21 | 1.21 |
| 285.39 | 2.66 | 2.66 |
| 304.22 | 3.38 | 3.38 |
| 749.00 | 1.90 | 1.90 |
| 314.47 | 4.72 | 4.72 |
| 110.11 | 1.10 | 1.10 |
| 68.08 | 0.41 | 0.41 |
| 138.13 | 1.18 | 1.18 |
| 124.14 | 1.40 | 1.40 |
| 124.14 | 1.40 | 1.40 |
| 137.14 | 0.97 | 0.97 |
| 46.07 | 0.00 | 0.00 |
| 360.88 | 7.27 | 7.27 |
| 399.44 | 2.87 | 2.87 |
| 144.21 | 2.29 | 2.29 |
| 369.59 | 4.84 | 4.84 |
| 352.77 | 2.81 | 2.81 |
| 151.16 | 1.35 | 1.35 |
| 68.08 | 1.28 | 1.28 |
| 354.49 | 6.50 | 6.50 |
| 215.69 | 1.78 | 1.78 |
| 238.16 | 0.07 | 0.07 |
| 108.14 | 1.70 | 1.70 |
| 137.14 | 0.81 | 0.81 |
| 222.24 | 3.46 | 3.46 |
| 381.38 | 3.51 | 3.51 |
| 766.96 | 3.09 | 3.09 |
| 156.57 | 2.04 | 2.04 |
| 201.25 | 2.69 | 2.69 |
| 358.43 | 1.77 | 1.77 |
| 272.39 | 3.61 | 3.61 |
| 143.19 | 2.42 | 2.42 |
| 368.39 | 3.37 | 3.37 |
| 110.11 | 1.10 | 1.10 |
| 386.53 | 4.66 | 4.66 |
| 290.45 | 3.96 | 3.96 |
| 109.13 | 0.97 | 0.97 |
| 106.17 | 2.30 | 2.30 |
| 110.11 | 1.10 | 1.10 |
| 137.14 | 0.49 | 0.49 |
| 125.17 | 1.65 | 1.65 |
| 150.18 | 1.15 | 1.15 |
| 144.17 | 0.77 | 0.77 |
| 76.10 | -0.64 | -0.64 |
| 116.16 | 1.51 | 1.51 |
| 474.37 | 1.23 | 1.23 |
| 608.69 | 4.17 | 4.17 |
| 167.21 | 0.64 | 0.64 |
| 269.13 | 4.00 | 4.00 |
| 356.06 | 5.86 | 5.86 |
| 286.24 | 2.28 | 2.28 |
| 206.33 | 2.79 | 2.79 |
| 563.65 | 6.00 | 6.00 |
| 482.44 | 2.36 | 2.36 |
| 136.20 | 1.33 | 1.33 |
| 505.46 | 4.18 | 4.18 |
| 262.27 | 3.19 | 3.19 |
| 276.21 | 3.21 | 3.21 |
| 310.48 | 5.06 | 5.06 |
| 147.09 | -0.68 | -0.68 |
| 180.21 | 2.78 | 2.78 |
| 250.38 | 3.77 | 3.77 |
| 270.24 | 1.89 | 1.89 |
| 254.24 | 2.18 | 2.18 |
| 284.22 | 1.57 | 1.57 |
| 305.21 | 1.93 | 1.93 |
| 380.91 | 4.48 | 4.48 |
| 226.23 | 2.23 | 2.23 |
| 215.89 | 4.30 | 4.30 |
| 215.89 | 4.30 | 4.30 |
| 181.45 | 3.65 | 3.65 |
| 181.45 | 3.65 | 3.65 |
| 147.00 | 2.99 | 2.99 |
| 167.85 | 2.59 | 2.59 |
| 119.38 | 1.99 | 1.99 |
| 147.00 | 2.99 | 2.99 |
| 198.14 | 0.19 | 0.19 |
| 132.16 | 1.90 | 1.90 |
| 240.21 | 1.87 | 1.87 |
| 466.56 | 2.88 | 2.88 |
| 361.40 | 4.11 | 4.11 |
| 305.42 | 3.79 | 3.79 |
| 407.99 | 4.46 | 4.46 |
| 228.25 | 2.97 | 2.97 |
| 318.33 | 3.56 | 3.56 |
| 286.46 | 5.51 | 5.51 |
| 136.15 | 1.69 | 1.69 |
| 224.22 | -0.71 | -0.71 |
| 116.21 | 0.46 | 0.46 |
| 246.40 | 4.57 | 4.57 |
| 108.14 | 0.85 | 0.85 |
| 150.21 | 1.85 | 1.85 |
| 266.34 | 4.66 | 4.66 |
| 384.65 | 7.62 | 7.62 |
| 197.45 | 3.35 | 3.35 |
| 248.31 | 1.68 | 1.68 |
| 166.13 | 1.08 | 1.08 |
| 284.44 | 5.72 | 5.72 |
| 145.16 | 1.94 | 1.94 |
| 212.30 | 3.13 | 3.13 |
| 231.29 | 2.95 | 2.95 |
| 267.16 | 3.75 | 3.75 |
| 193.25 | 3.58 | 3.58 |
| 266.38 | 4.16 | 4.16 |
| 223.23 | 2.04 | 2.04 |
| 190.27 | 1.47 | 1.47 |
| 182.22 | 2.92 | 2.92 |
| 290.32 | 2.57 | 2.57 |
| 69.00 | 0.14 | 0.14 |
| 256.35 | 5.76 | 5.76 |
| 228.29 | 3.42 | 3.42 |
| 150.21 | 1.88 | 1.88 |
| 180.23 | 1.89 | 1.89 |
| 154.60 | 2.11 | 2.11 |
| 168.15 | 1.19 | 1.19 |
| 154.12 | 0.88 | 0.88 |
| 198.13 | 1.52 | 1.52 |
| 130.19 | 2.04 | 2.04 |
| 65.01 | 0.87 | 0.87 |
| 109.13 | 0.97 | 0.97 |
| 172.27 | 3.21 | 3.21 |
| 200.32 | 3.99 | 3.99 |
| 197.45 | 3.35 | 3.35 |
| 231.89 | 4.01 | 4.01 |
| 346.47 | 2.67 | 2.67 |
| 168.11 | 1.50 | 1.50 |
| 384.45 | 6.46 | 6.46 |
| 172.32 | 1.67 | 1.67 |
| 105.14 | -1.44 | -1.44 |
| 191.01 | 2.69 | 2.69 |
| 281.35 | 1.04 | 1.04 |
| 240.44 | 2.06 | 2.06 |
| 193.25 | 2.23 | 2.23 |
| 663.90 | 4.75 | 4.75 |
| 416.95 | 4.61 | 4.61 |
| 270.55 | 3.18 | 3.18 |
| 220.36 | 4.69 | 4.69 |
| 147.18 | 1.66 | 1.66 |
| 198.26 | 3.40 | 3.40 |
| 137.14 | 1.90 | 1.90 |
| 180.25 | 2.83 | 2.83 |
| 96.94 | 1.94 | 1.94 |
| 236.74 | 3.73 | 3.73 |
| 112.99 | 2.20 | 2.20 |
| 220.23 | 0.83 | 0.83 |
| 129.38 | 1.58 | 1.58 |
| 108.97 | 1.40 | 1.40 |
| 206.33 | 3.83 | 3.83 |
| 102.14 | 1.01 | 1.01 |
| 183.12 | 1.09 | 1.09 |
| 153.14 | 0.76 | 0.76 |
| 163.14 | 1.47 | 1.47 |
| 186.10 | 1.64 | 1.64 |
| 153.14 | 0.76 | 0.76 |
| 172.57 | 1.83 | 1.83 |
| 220.98 | 2.68 | 2.68 |
| 212.25 | 3.33 | 3.33 |
| 217.31 | 3.69 | 3.69 |
| 152.15 | 1.15 | 1.15 |
| 171.58 | 2.33 | 2.33 |
| 543.87 | 6.47 | 6.47 |
| 96.08 | 1.09 | 1.09 |
| 126.11 | 0.58 | 0.58 |
| 245.88 | 2.52 | 2.52 |
| 142.20 | 3.15 | 3.15 |
| 320.05 | 5.93 | 5.93 |
| 142.59 | 2.35 | 2.35 |
| 409.78 | 5.68 | 5.68 |
| 345.65 | 5.21 | 5.21 |
| 364.91 | 5.27 | 5.27 |
| 354.49 | 6.50 | 6.50 |
| 318.03 | 6.19 | 6.19 |
| 406.93 | 3.69 | 3.69 |
| 373.32 | 5.24 | 5.24 |
| 302.46 | 4.27 | 4.27 |
| 307.29 | 2.23 | 2.23 |
| 288.43 | 3.88 | 3.88 |
| 330.80 | 3.68 | 3.68 |
| 448.09 | 6.07 | 6.07 |
| 166.22 | 2.40 | 2.40 |
| 307.10 | -1.06 | -1.06 |
| 166.25 | 1.28 | 1.28 |
| 123.15 | 1.28 | 1.28 |
| 137.18 | 1.46 | 1.46 |
| 336.45 | 3.33 | 3.33 |
| 370.49 | 5.60 | 5.60 |
| 485.80 | 6.53 | 6.53 |
| 564.69 | 7.29 | 7.29 |
| 180.17 | -1.04 | -1.04 |
| 300.59 | 2.91 | 2.91 |
| 167.21 | 3.32 | 3.32 |
| 166.22 | 2.40 | 2.40 |
| 134.13 | 1.07 | 1.07 |
| 140.57 | 2.15 | 2.15 |
| 376.58 | 5.51 | 5.51 |
| 244.29 | 2.54 | 2.54 |
| 244.21 | -3.17 | -3.17 |
| 228.25 | 2.82 | 2.82 |
| 346.34 | 2.18 | 2.18 |
| 312.45 | 4.64 | 4.64 |
| 152.22 | 1.34 | 1.34 |
| 76.12 | -0.81 | -0.81 |
| 225.29 | 4.17 | 4.17 |
| 340.42 | 3.57 | 3.57 |
| 145.14 | 0.63 | 0.63 |
| 277.27 | 1.15 | 1.15 |
| 91.14 | -1.31 | -1.31 |
| 278.35 | 3.60 | 3.60 |
| 312.45 | 4.64 | 4.64 |
| 207.02 | 2.48 | 2.48 |
| 307.82 | 3.34 | 3.34 |
| 342.40 | 1.79 | 1.79 |
| 1255.44 | ||
| 296.54 | 6.36 | 6.36 |
| 350.59 | 4.72 | 4.72 |
| 162.19 | 2.45 | 2.45 |
| 136.24 | 3.00 | 3.00 |
| 152.24 | 2.40 | 2.40 |
| 152.24 | 2.88 | 2.88 |
| 563.99 | 1.03 | 1.03 |
| 150.22 | 2.49 | 2.49 |
| 317.33 | 2.00 | 2.00 |
| 297.27 | -2.63 | -2.63 |
| 490.64 | 4.62 | 4.62 |
| 198.65 | 2.43 | 2.43 |
| 403.46 | 0.32 | 0.32 |
| 318.37 | 3.58 | 3.58 |
| 287.17 | 4.56 | 4.56 |
| 322.40 | 3.29 | 3.29 |
| 579.99 | 0.00 | 0.00 |
| 160.17 | 2.10 | 2.10 |
| 228.25 | 2.75 | 2.75 |
| 142.11 | 0.47 | 0.47 |
| 1229.32 | ||
| 228.25 | 2.63 | 2.63 |
| 194.27 | 3.22 | 3.22 |
| 244.21 | -3.01 | -3.01 |
| 173.39 | 1.03 | 1.03 |
| 207.84 | 1.60 | 1.60 |
| 414.47 | 6.06 | 6.06 |
| 320.05 | 5.93 | 5.93 |
| 194.23 | 2.35 | 2.35 |
| 121.18 | 2.12 | 2.12 |
| 135.21 | 2.19 | 2.19 |
| 122.17 | 1.16 | 1.16 |
| 307.26 | 5.75 | 5.75 |
| 150.23 | -1.43 | -1.43 |
| 373.91 | 2.50 | 2.50 |
| 142.59 | 1.50 | 1.50 |
| 184.24 | 3.13 | 3.13 |
| 146.14 | 0.11 | 0.11 |
| 158.20 | 2.00 | 2.00 |
| 194.26 | 2.28 | 2.28 |
| 274.27 | 2.27 | 2.27 |
| 230.26 | 2.55 | 2.55 |
| 780.95 | 2.22 | 2.22 |
| 294.39 | 3.53 | 3.53 |
| 258.27 | 2.83 | 2.83 |
| 174.16 | 1.93 | 1.93 |
| 104.11 | 0.11 | 0.11 |
| 469.97 | ||
| 330.36 | 2.12 | 2.12 |
| 317.71 | 0.61 | 0.61 |
| 332.48 | 4.40 | 4.40 |
| 72.06 | -0.07 | -0.07 |
| 380.87 | 5.87 | 5.87 |
| 340.29 | 4.19 | 4.19 |
| 313.87 | 4.17 | 4.17 |
| 192.52 | 1.40 | 1.40 |
| 249.71 | 2.66 | 2.66 |
| 444.70 | 5.80 | 5.80 |
| 338.44 | 3.72 | 3.72 |
| 361.49 | 5.77 | 5.77 |
| 178.14 | -0.25 | -0.25 |
| 121.18 | 1.89 | 1.89 |
| 142.59 | 2.35 | 2.35 |
| 488.59 | 5.20 | 5.20 |
| 100.12 | 0.55 | 0.55 |
| 182.16 | 2.20 | 2.20 |
| 390.56 | 6.43 | 6.43 |
| 106.55 | 1.55 | 1.55 |
| 344.39 | 1.43 | 1.43 |
| 284.31 | 0.68 | 0.68 |
| 248.71 | 2.97 | 2.97 |
| 218.83 | 1.34 | 1.34 |
| 150.18 | 1.23 | 1.23 |
| 122.17 | 1.16 | 1.16 |
| 277.41 | 4.13 | 4.13 |
| 259.18 | 2.21 | 2.21 |
| 286.33 | 3.27 | 3.27 |
| 272.26 | 2.86 | 2.86 |
| 164.38 | 1.59 | 1.59 |
| 249.27 | -0.27 | -0.27 |
| 165.15 | 1.80 | 1.80 |
| 116.12 | -0.29 | -0.29 |
| 176.17 | 1.96 | 1.96 |
| 267.24 | 2.68 | 2.68 |
| 314.30 | 2.01 | 2.01 |
| 187.33 | 2.57 | 2.57 |
| 260.34 | 5.17 | 5.17 |
| 336.74 | ||
| 244.21 | -3.17 | -3.17 |
| 74.44 | 0.13 | 0.13 |
| 287.17 | 3.83 | 3.83 |
| 252.32 | 5.64 | 5.64 |
| 222.24 | 1.24 | 1.24 |
| 320.40 | 3.10 | 3.10 |
| 197.45 | 3.35 | 3.35 |
| 348.96 | 5.45 | 5.45 |
| 118.18 | 2.72 | 2.72 |
| 171.58 | 2.33 | 2.33 |
| 278.35 | 6.30 | 6.30 |
| 150.89 | -2.94 | -2.94 |
| 194.27 | 2.85 | 2.85 |
| 414.56 | 4.48 | 4.48 |
| 492.39 | -1.19 | -1.19 |
| 230.26 | 2.30 | 2.30 |
| 148.12 | 1.00 | 1.00 |
| 268.27 | 3.12 | 3.12 |
| 294.18 | ||
| 141.60 | 2.23 | 2.23 |
| 271.50 | ||
| 134.18 | 0.46 | 0.46 |
| 262.35 | 3.76 | 3.76 |
| 117.15 | 1.87 | 1.87 |
| 226.28 | 3.16 | 3.16 |
| 164.25 | 1.82 | 1.82 |
| 154.17 | -0.45 | -0.45 |
| 171.07 | 2.26 | 2.26 |
| 288.44 | 4.51 | 4.51 |
| 463.70 | 4.05 | 4.05 |
| 211.65 | 2.07 | 2.07 |
| 220.36 | 4.11 | 4.11 |
| 252.04 | ||
| 151.16 | 2.21 | 2.21 |
| 237.26 | 2.35 | 2.35 |
| 269.77 | 2.99 | 2.99 |
| 370.57 | 6.07 | 6.07 |
| 260.89 | 4.21 | 4.21 |
| 394.51 | 5.81 | 5.81 |
| 380.48 | 5.72 | 5.72 |
| 234.38 | 4.52 | 4.52 |
| 129.11 | 1.55 | 1.55 |
| 132.16 | 0.59 | 0.59 |
| 287.23 | 3.41 | 3.41 |
| 214.27 | 3.03 | 3.03 |
| 96.94 | 1.94 | 1.94 |
| 266.53 | ||
| 252.32 | 5.64 | 5.64 |
| 263.38 | 5.35 | 5.35 |
| 175.01 | 2.81 | 2.81 |
| 198.22 | 3.61 | 3.61 |
| 174.16 | 1.93 | 1.93 |
| 82.10 | 1.59 | 1.59 |
| 101.19 | 1.38 | 1.38 |
| 104.15 | 0.14 | 0.14 |
| 302.28 | 1.32 | 1.32 |
| 103.12 | 1.06 | 1.06 |
| 226.32 | 4.25 | 4.25 |
| 217.44 | 1.16 | 1.16 |
| 393.73 | 2.58 | 2.58 |
| 89.53 | 1.14 | 1.14 |
| 78.07 | 0.59 | 0.59 |
| 181.32 | 3.24 | 3.24 |
| 164.25 | 2.12 | 2.12 |
| 365.96 | 5.60 | 5.60 |
| 189.19 | 0.22 | 0.22 |
| 616.79 | 3.41 | 3.41 |
| 258.28 | 3.63 | 3.63 |
| 197.45 | 3.35 | 3.35 |
| 183.32 | ||
| 233.11 | 4.12 | 4.12 |
| 186.03 | ||
| 204.78 | 5.15 | 5.15 |
| 298.00 | ||
| 72.11 | 0.99 | 0.99 |
| 176.62 | 1.61 | 1.61 |
| 150.18 | 1.78 | 1.78 |
| 197.45 | 3.35 | 3.35 |
| 109.94 | 1.31 | 1.31 |
| 273.29 | 3.40 | 3.40 |
| 120.15 | 1.81 | 1.81 |
| 296.28 | 3.31 | 3.31 |
| 118.18 | 0.79 | 0.79 |
| 181.15 | 1.60 | 1.60 |
| 241.29 | 2.67 | 2.67 |
| 350.46 | 6.20 | 6.20 |
| 218.21 | 0.04 | 0.04 |
| 122.17 | 1.16 | 1.16 |
| 182.13 | 1.81 | 1.81 |
| 138.25 | 3.37 | 3.37 |
| 345.65 | 3.22 | 3.22 |
| 302.32 | 0.49 | 0.49 |
| 195.22 | 1.88 | 1.88 |
| 204.31 | 3.36 | 3.36 |
| 152.15 | 1.49 | 1.49 |
| 214.22 | 0.46 | 0.46 |
| 324.84 | 2.15 | 2.15 |
| 178.26 | 2.50 | 2.50 |
| 546.81 | 11.25 | 11.25 |
| 83.13 | 1.70 | 1.70 |
| 276.29 | 2.19 | 2.19 |
| 154.12 | 0.88 | 0.88 |
| 152.19 | 2.41 | 2.41 |
| 305.83 | 0.76 | 0.76 |
| 151.21 | 2.13 | 2.13 |
| 185.23 | 3.14 | 3.14 |
| 248.72 | 3.27 | 3.27 |
| 159.62 | 1.28 | 1.28 |
| 130.20 | 1.37 | 1.37 |
| 358.55 | 6.46 | 6.46 |
| 272.77 | 4.55 | 4.55 |
| 251.24 | 1.64 | 1.64 |
| 103.12 | 1.34 | 1.34 |
| 231.89 | 4.01 | 4.01 |
| 241.73 | 0.24 | 0.24 |
| 226.27 | 2.01 | 2.01 |
| 182.13 | 1.81 | 1.81 |
| 194.23 | 1.63 | 1.63 |
| 229.13 | ||
| 398.48 | 4.59 | 4.59 |
| 330.21 | 1.69 | 1.69 |
| 219.29 | 4.58 | 4.58 |
| 234.34 | 3.79 | 3.79 |
| 927.02 | 4.39 | 4.39 |
| 163.00 | 2.70 | 2.70 |
| 406.28 | -1.20 | -1.20 |
| 268.40 | 5.28 | 5.28 |
| 830.83 | 9.23 | 9.23 |
| 213.35 | 3.27 | 3.27 |
| 80.09 | 0.81 | 0.81 |
| 210.23 | 2.17 | 2.17 |
| 114.14 | 0.94 | 0.94 |
| 179.22 | 3.39 | 3.39 |
| 188.01 | 2.96 | 2.96 |
| 158.20 | 1.66 | 1.66 |
| 411.80 | 5.38 | 5.38 |
| 643.59 | 8.05 | 8.05 |
| 223.49 | 3.41 | 3.41 |
| 197.45 | 3.35 | 3.35 |
| 150.18 | 2.15 | 2.15 |
| 275.17 | 2.39 | 2.39 |
| 251.08 | ||
| 242.40 | 4.32 | 4.32 |
| 96.13 | 1.32 | 1.32 |
| 284.44 | 5.72 | 5.72 |
| 344.41 | 3.17 | 3.17 |
| 186.25 | 1.78 | 1.78 |
| 138.13 | 0.77 | 0.77 |
| 108.14 | 0.85 | 0.85 |
| 151.16 | 2.21 | 2.21 |
| 368.37 | 6.26 | 6.26 |
| 254.29 | 3.17 | 3.17 |
| 248.96 | ||
| 212.38 | 4.70 | 4.70 |
| 281.10 | ||
| 198.22 | 3.83 | 3.83 |
| 380.48 | 5.72 | 5.72 |
| 298.29 | 0.15 | 0.15 |
| 410.45 | 7.18 | 7.18 |
| 158.56 | 2.20 | 2.20 |
| 231.89 | 4.01 | 4.01 |
| 496.90 | -1.24 | -1.24 |
| 57.05 | -0.05 | -0.05 |
| 323.83 | 3.80 | 3.80 |
| 326.05 | 3.82 | 3.82 |
| 123.15 | 1.28 | 1.28 |
| 303.84 | 3.23 | 3.23 |
| 254.38 | 3.41 | 3.41 |
| 84.08 | -1.01 | -1.01 |
| 223.49 | 3.85 | 3.85 |
| 118.18 | 1.06 | 1.06 |
| 165.15 | 1.80 | 1.80 |
| 103.08 | -1.27 | -1.27 |
| 100.12 | 0.74 | 0.74 |
| 206.28 | 2.76 | 2.76 |
| 218.30 | 3.29 | 3.29 |
| 130.19 | 2.97 | 2.97 |
| 81.12 | 1.48 | 1.48 |
| 87.12 | 1.25 | 1.25 |
| 103.84 | ||
| 152.96 | 1.07 | 1.07 |
| 676.84 | 3.03 | 3.03 |