Basic Information
ID: ALA2114899
Type: Functional
Description: PubChem BioAssay. Dose response validation of uHTS antagonist hits from Gli-SUFU in a luminescent cytotoxicity assay. (Class of assay: confirmatory)
Activity Charts
Bioactivity
Activity Types for Assay ALA2114899
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 264.32 | 2.47 | 2.47 |
| 378.44 | 3.42 | 3.42 |
| 343.79 | 3.87 | 3.87 |
| 510.18 | 6.49 | 6.49 |
| 360.28 | 2.82 | 2.82 |
| 299.80 | 3.49 | 3.49 |
| 438.19 | 4.30 | 4.30 |
| 393.74 | 4.19 | 4.19 |
| 358.27 | 2.75 | 2.75 |
| 396.33 | 4.70 | 4.70 |
| 359.86 | 2.69 | 2.69 |
| 351.42 | 3.13 | 3.13 |
| 313.40 | 4.65 | 4.65 |
| 478.21 | 4.60 | 4.60 |
| 351.41 | 3.47 | 3.47 |
| 482.05 | 4.64 | 4.64 |
| 339.69 | 3.36 | 3.36 |
| 412.60 | 4.34 | 4.34 |
| 431.41 | 4.56 | 4.56 |
| 394.45 | 2.00 | 2.00 |
| 497.60 | 4.61 | 4.61 |
| 282.39 | 4.02 | 4.02 |
| 356.25 | 3.17 | 3.17 |
| 374.31 | 3.21 | 3.21 |
| 279.30 | 4.20 | 4.20 |
| 398.24 | 2.00 | 2.00 |
| 437.41 | 4.44 | 4.44 |
| 375.40 | 3.12 | 3.12 |
| 309.20 | 4.24 | 4.24 |
| 436.49 | 1.52 | 1.52 |
| 365.91 | 2.98 | 2.98 |
| 333.46 | 4.25 | 4.25 |
| 385.58 | 5.19 | 5.19 |
| 404.29 | 3.61 | 3.61 |
| 482.65 | 5.57 | 5.57 |
| 457.37 | 3.68 | 3.68 |
| 344.43 | 2.52 | 2.52 |
| 338.41 | 3.38 | 3.38 |
| 382.85 | 4.50 | 4.50 |
| 332.85 | 3.52 | 3.52 |
| 439.55 | 3.43 | 3.43 |
| 340.49 | 4.35 | 4.35 |
| 400.53 | 1.87 | 1.87 |
| 355.41 | 4.76 | 4.76 |
| 486.57 | 2.92 | 2.92 |
| 399.47 | 3.44 | 3.44 |
| 298.17 | 2.97 | 2.97 |
| 446.06 | 5.08 | 5.08 |
| 382.51 | 2.88 | 2.88 |
| 364.45 | 3.90 | 3.90 |
| 377.49 | 4.38 | 4.38 |
| 395.25 | 2.35 | 2.35 |
| 445.56 | 5.35 | 5.35 |
| 442.52 | 3.99 | 3.99 |
| 416.51 | 1.51 | 1.51 |
| 449.38 | 5.11 | 5.11 |
| 407.38 | 3.75 | 3.75 |
| 359.29 | 3.54 | 3.54 |
| 488.61 | 3.24 | 3.24 |
| 384.46 | 2.46 | 2.46 |
| 386.28 | 4.50 | 4.50 |
| 437.79 | 4.59 | 4.59 |
| 401.47 | 4.64 | 4.64 |
| 285.34 | 3.33 | 3.33 |
| 382.53 | 3.82 | 3.82 |
| 381.48 | 3.01 | 3.01 |
| 369.47 | 1.87 | 1.87 |
| 383.49 | 3.56 | 3.56 |
| 479.60 | 3.89 | 3.89 |
| 479.62 | 2.17 | 2.17 |
| 373.49 | 4.24 | 4.24 |
| 428.51 | 3.06 | 3.06 |
| 415.31 | 3.17 | 3.17 |
| 443.55 | 3.72 | 3.72 |
| 378.48 | 4.27 | 4.27 |
| 360.80 | 1.70 | 1.70 |
| 337.29 | 4.95 | 4.95 |
| 395.46 | 3.43 | 3.43 |
| 476.60 | 5.46 | 5.46 |
| 282.35 | 2.72 | 2.72 |
| 462.35 | 5.04 | 5.04 |
| 366.42 | 3.33 | 3.33 |
| 659.87 | 4.48 | 4.48 |
| 363.42 | 3.76 | 3.76 |
| 410.47 | 3.32 | 3.32 |
| 399.59 | 4.64 | 4.64 |
| 299.36 | 2.94 | 2.94 |
| 300.79 | 3.28 | 3.28 |
| 277.75 | 3.27 | 3.27 |
| 322.43 | 2.26 | 2.26 |
| 449.53 | 4.04 | 4.04 |
| 487.61 | 4.17 | 4.17 |
| 435.31 | 4.76 | 4.76 |
| 443.51 | 2.80 | 2.80 |
| 423.47 | 3.75 | 3.75 |
| 253.43 | 3.07 | 3.07 |
| 327.41 | 3.56 | 3.56 |
| 423.38 | 3.77 | 3.77 |
| 390.51 | 3.58 | 3.58 |
| 447.51 | 2.41 | 2.41 |
| 447.61 | 4.69 | 4.69 |
| 428.62 | 3.50 | 3.50 |
| 366.49 | 4.06 | 4.06 |
| 355.46 | 3.46 | 3.46 |
| 310.47 | 4.34 | 4.34 |
| 270.36 | 3.05 | 3.05 |
| 477.61 | 1.93 | 1.93 |
| 392.34 | 4.01 | 4.01 |
| 425.42 | 3.53 | 3.53 |
| 397.54 | 3.95 | 3.95 |
| 326.62 | 4.20 | 4.20 |
| 408.55 | 3.68 | 3.68 |
| 419.59 | 3.93 | 3.93 |
| 488.20 | 5.36 | 5.36 |
| 399.44 | 3.60 | 3.60 |
| 329.22 | 3.41 | 3.41 |
| 393.75 | 5.05 | 5.05 |
| 298.39 | 3.68 | 3.68 |
| 429.48 | 3.64 | 3.64 |
| 415.49 | 4.22 | 4.22 |
| 349.36 | 3.63 | 3.63 |
| 481.54 | 3.61 | 3.61 |
| 368.50 | 3.80 | 3.80 |
| 441.60 | 3.51 | 3.51 |
| 385.43 | 5.05 | 5.05 |
| 346.45 | 3.56 | 3.56 |
| 508.67 | 2.86 | 2.86 |
| 382.15 | 2.09 | 2.09 |
| 492.00 | 3.47 | 3.47 |
| 366.51 | 3.37 | 3.37 |
| 663.90 | 5.22 | 5.22 |
| 350.40 | 2.46 | 2.46 |
| 307.87 | 4.04 | 4.04 |
| 547.60 | 6.38 | 6.38 |
| 346.45 | 3.24 | 3.24 |
| 381.39 | 3.72 | 3.72 |
| 293.37 | 4.23 | 4.23 |
| 302.44 | 3.40 | 3.40 |
| 382.35 | 3.95 | 3.95 |
| 405.31 | 5.00 | 5.00 |
| 418.95 | 4.55 | 4.55 |
| 394.52 | 3.38 | 3.38 |
| 267.30 | 4.03 | 4.03 |
| 436.52 | 4.80 | 4.80 |
| 457.62 | 4.35 | 4.35 |
| 495.52 | 3.87 | 3.87 |
| 467.79 | 5.18 | 5.18 |
| 458.61 | 5.32 | 5.32 |
| 417.51 | 5.45 | 5.45 |
| 329.84 | 3.61 | 3.61 |
| 396.29 | 3.00 | 3.00 |
| 259.28 | 3.38 | 3.38 |
| 380.33 | 3.70 | 3.70 |
| 434.28 | 2.99 | 2.99 |
| 337.38 | 3.47 | 3.47 |
| 439.38 | 4.59 | 4.59 |
| 425.53 | 1.53 | 1.53 |
| 435.54 | 1.12 | 1.12 |
| 408.47 | 5.00 | 5.00 |
| 423.56 | 2.42 | 2.42 |
| 542.08 | 5.19 | 5.19 |
| 295.81 | 4.15 | 4.15 |
| 376.84 | 4.32 | 4.32 |
| 471.46 | 5.43 | 5.43 |
| 410.43 | 2.72 | 2.72 |
| 492.55 | -0.10 | -0.10 |
| 287.45 | 3.19 | 3.19 |
| 411.51 | 1.02 | 1.02 |
| 230.26 | 2.59 | 2.59 |
| 274.32 | 4.00 | 4.00 |
| 359.29 | 3.54 | 3.54 |
| 543.67 | 4.31 | 4.31 |
| 359.50 | 3.11 | 3.11 |
| 400.36 | 4.57 | 4.57 |
| 445.79 | 4.71 | 4.71 |
| 389.59 | 4.62 | 4.62 |
| 465.34 | 4.77 | 4.77 |
| 357.41 | 0.85 | 0.85 |
| 304.35 | 3.68 | 3.68 |
| 392.91 | 3.31 | 3.31 |
| 430.39 | 4.85 | 4.85 |
| 374.40 | 0.52 | 0.52 |
| 371.28 | 5.47 | 5.47 |
| 355.26 | 2.94 | 2.94 |
| 477.97 | 2.57 | 2.57 |
| 359.43 | 3.40 | 3.40 |
| 311.43 | 3.29 | 3.29 |
| 350.30 | 4.18 | 4.18 |
| 463.54 | 4.19 | 4.19 |
| 350.45 | 5.32 | 5.32 |
| 391.43 | 3.07 | 3.07 |
| 426.32 | 2.72 | 2.72 |
| 348.37 | 4.20 | 4.20 |
| 537.69 | 4.13 | 4.13 |
| 538.71 | 3.35 | 3.35 |
| 419.57 | 4.09 | 4.09 |
| 402.88 | 4.46 | 4.46 |
| 313.40 | 4.65 | 4.65 |
| 372.88 | 5.01 | 5.01 |
| 495.52 | 3.87 | 3.87 |
| 373.37 | 2.85 | 2.85 |
| 469.44 | 5.32 | 5.32 |
| 320.46 | 2.83 | 2.83 |
| 393.91 | 2.94 | 2.94 |
| 398.49 | 3.48 | 3.48 |
| 363.44 | 1.91 | 1.91 |
| 343.36 | 1.22 | 1.22 |
| 416.57 | 3.44 | 3.44 |
| 411.48 | 3.21 | 3.21 |
| 362.36 | 4.24 | 4.24 |
| 466.61 | 4.28 | 4.28 |
| 413.46 | 3.40 | 3.40 |
| 433.35 | 4.53 | 4.53 |
| 277.37 | 4.16 | 4.16 |
| 385.85 | 4.05 | 4.05 |
| 403.44 | 4.08 | 4.08 |
| 443.51 | 3.46 | 3.46 |
| 316.16 | 3.35 | 3.35 |
| 361.47 | 3.07 | 3.07 |
| 288.50 | 5.23 | 5.23 |
| 357.41 | 3.99 | 3.99 |
| 449.47 | 4.40 | 4.40 |
| 326.79 | 3.79 | 3.79 |
| 433.92 | 4.16 | 4.16 |
| 344.40 | 3.36 | 3.36 |
| 436.38 | 4.49 | 4.49 |
| 455.55 | 2.40 | 2.40 |
| 413.59 | 3.59 | 3.59 |
| 299.33 | 2.06 | 2.06 |
| 432.56 | 1.68 | 1.68 |
| 283.80 | 3.79 | 3.79 |
| 382.44 | 4.22 | 4.22 |
| 392.43 | 3.99 | 3.99 |
| 352.51 | 4.78 | 4.78 |
| 477.94 | 4.41 | 4.41 |
| 301.48 | 3.66 | 3.66 |
| 434.51 | 2.23 | 2.23 |
| 359.50 | 3.21 | 3.21 |
| 443.59 | 1.40 | 1.40 |
| 334.38 | 3.81 | 3.81 |
| 449.98 | 4.75 | 4.75 |
| 433.57 | 2.40 | 2.40 |
| 326.45 | 4.44 | 4.44 |
| 391.54 | 3.22 | 3.22 |
| 317.40 | 3.82 | 3.82 |
| 399.52 | 3.09 | 3.09 |
| 332.37 | 4.62 | 4.62 |
| 411.38 | 1.56 | 1.56 |
| 429.75 | 4.60 | 4.60 |
| 329.36 | 4.47 | 4.47 |
| 432.54 | 3.45 | 3.45 |
| 481.60 | 3.69 | 3.69 |
| 350.45 | 4.88 | 4.88 |
| 380.50 | 2.52 | 2.52 |
| 275.40 | 3.98 | 3.98 |
| 380.43 | 3.53 | 3.53 |
| 582.69 | 3.03 | 3.03 |
| 486.67 | 6.18 | 6.18 |
| 357.89 | 4.12 | 4.12 |
| 281.79 | 3.69 | 3.69 |
| 375.35 | 2.81 | 2.81 |
| 467.57 | 2.81 | 2.81 |
| 390.90 | 3.86 | 3.86 |
| 317.44 | 4.55 | 4.55 |
| 410.54 | 3.37 | 3.37 |
| 513.05 | 4.57 | 4.57 |
| 390.01 | 3.88 | 3.88 |
| 316.38 | 3.25 | 3.25 |
| 281.14 | 3.57 | 3.57 |
| 334.42 | 3.88 | 3.88 |
| 385.47 | 1.76 | 1.76 |
| 504.68 | 3.27 | 3.27 |
| 420.99 | 6.35 | 6.35 |
| 387.35 | 3.99 | 3.99 |
| 536.65 | 4.09 | 4.09 |
| 681.83 | 5.35 | 5.35 |
| 524.64 | 3.79 | 3.79 |
| 373.49 | 4.24 | 4.24 |
| 701.82 | 5.37 | 5.37 |
| 319.41 | 4.04 | 4.04 |
| 388.49 | 3.80 | 3.80 |
| 521.67 | 3.56 | 3.56 |
| 554.69 | 3.26 | 3.26 |
| 445.54 | 2.68 | 2.68 |
| 438.20 | 5.47 | 5.47 |
| 701.82 | 5.67 | 5.67 |
| 448.57 | 4.42 | 4.42 |
| 408.50 | 4.45 | 4.45 |
| 451.51 | 2.11 | 2.11 |
| 441.37 | 4.06 | 4.06 |
| 401.10 | 2.68 | 2.68 |
| 912.21 | 4.78 | 4.78 |
| 681.83 | 5.04 | 5.04 |
| 444.63 | 4.12 | 4.12 |
| 529.65 | 3.43 | 3.43 |
| 453.75 | 4.70 | 4.70 |
| 532.04 | 4.14 | 4.14 |
| 754.88 | 6.02 | 6.02 |
| 529.61 | 4.07 | 4.07 |
| 352.43 | 2.65 | 2.65 |
| 406.53 | 5.41 | 5.41 |
| 505.64 | 4.36 | 4.36 |
| 500.61 | 2.71 | 2.71 |
| 549.99 | ||
| 701.82 | 5.67 | 5.67 |
| 301.19 | 4.16 | 4.16 |
| 701.82 | 5.67 | 5.67 |
| 527.72 | 3.67 | 3.67 |
| 562.85 | 7.73 | 7.73 |
| 665.79 | 4.50 | 4.50 |
| 625.72 | 3.63 | 3.63 |
| 521.67 | 3.56 | 3.56 |
| 295.43 | 3.43 | 3.43 |
| 754.88 | 6.02 | 6.02 |
| 639.75 | 4.32 | 4.32 |
| 402.46 | 1.31 | 1.31 |
| 341.25 | 3.38 | 3.38 |
| 543.67 | 3.47 | 3.47 |
| 358.33 | 1.57 | 1.57 |
| 253.43 | 3.07 | 3.07 |
| 352.82 | 4.53 | 4.53 |
| 639.75 | 4.02 | 4.02 |
| 701.82 | 5.67 | 5.67 |
| 665.79 | 4.50 | 4.50 |
| 262.70 | 2.67 | 2.67 |
| 349.82 | 4.14 | 4.14 |
| 465.31 | 4.67 | 4.67 |
| 338.37 | 2.44 | 2.44 |
| 390.30 | 5.65 | 5.65 |
| 287.30 | 2.47 | 2.47 |
| 425.45 | 0.93 | 0.93 |
| 320.35 | 2.95 | 2.95 |
| 390.49 | 2.63 | 2.63 |
| 335.41 | 3.42 | 3.42 |
| 285.43 | 4.58 | 4.58 |
| 283.40 | 2.50 | 2.50 |
| 625.72 | 3.93 | 3.93 |
| 404.51 | 3.02 | 3.02 |
| 276.38 | 4.70 | 4.70 |
| 285.37 | 4.02 | 4.02 |
| 330.78 | 2.52 | 2.52 |
| 429.50 | 2.99 | 2.99 |
| 389.43 | 4.29 | 4.29 |
| 320.40 | 3.11 | 3.11 |