Basic Information
ID: ALA2148625
Type: Binding
Description: Inhibition of human ROMK1 channel expressed in CHO cells coexpressing DHFR assessed as inhibition of 86Rb+ efflux after 35 mins by TopCount method
Organism: Homo sapiens
Cell type: CHO
Activity Charts
Bioactivity
Activity Types for Assay ALA2148625
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 235.29 | 1.04 | 1.04 |
| 384.44 | 2.91 | 2.91 |
| 339.44 | 3.00 | 3.00 |
| 364.45 | 2.87 | 2.87 |
| 361.45 | 2.50 | 2.50 |
| 364.45 | 2.87 | 2.87 |
| 381.44 | 2.53 | 2.53 |
| 406.49 | 3.65 | 3.65 |
| 417.51 | 3.45 | 3.45 |
| 471.56 | 4.34 | 4.34 |
| 411.50 | 3.17 | 3.17 |
| 357.43 | 3.14 | 3.14 |
| 373.88 | 3.65 | 3.65 |
| 407.44 | 4.02 | 4.02 |
| 369.47 | 3.01 | 3.01 |
| 417.53 | 2.40 | 2.40 |
| 370.41 | 2.86 | 2.86 |
| 398.46 | 3.30 | 3.30 |
| 398.46 | 3.47 | 3.47 |
| 398.46 | 3.29 | 3.29 |
| 398.46 | 3.29 | 3.29 |
| 344.46 | 2.83 | 2.83 |
| 378.44 | 2.16 | 2.16 |
| 406.48 | 2.43 | 2.43 |
| 375.47 | 2.63 | 2.63 |
| 392.46 | 2.30 | 2.30 |
| 393.46 | 2.77 | 2.77 |
| 409.92 | 3.28 | 3.28 |
| 454.37 | 3.39 | 3.39 |
| 405.50 | 2.64 | 2.64 |
| 419.53 | 3.03 | 3.03 |
| 459.47 | 3.53 | 3.53 |
| 431.54 | 3.17 | 3.17 |
| 421.57 | 3.35 | 3.35 |
| 404.51 | 2.67 | 2.67 |
| 453.56 | 2.03 | 2.03 |