Basic Information
ID: ALA2167992
Type: Binding
Description: Inhibition of human ADAMTS-5 expressed in CHO cells using WAAG-3R as substrate preincubated for 15 mins measured after 1 hr by FRET assay
Format: BAO_0000219
Organism: Homo sapiens
Cell type: CHO
Target: ADAMTS5(ALA2285)
Document: ALA2163235
Inhibition of human ADAMTS-5 expressed in CHO cells using WAAG-3R as substrate preincubated for 15 mins measured after 1 hr by FRET assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA2167992
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 472.92 | 2.47 | 2.47 |
| 644.75 | 5.56 | 5.56 |
| 606.78 | 4.55 | 4.55 |
| 576.75 | 4.54 | 4.54 |
| 540.72 | 3.65 | 3.65 |
| 619.24 | 5.48 | 5.48 |
| 619.24 | 5.48 | 5.48 |
| 612.85 | 5.44 | 5.44 |
| 660.90 | 6.50 | 6.50 |
| 662.89 | 4.23 | 4.23 |
| 609.81 | 4.70 | 4.70 |
| 609.81 | 4.70 | 4.70 |
| 602.79 | 4.97 | 4.97 |
| 600.80 | 4.53 | 4.53 |
| 600.80 | 4.53 | 4.53 |
| 582.68 | 4.20 | 4.20 |
| 561.63 | 4.44 | 4.44 |
| 543.76 | 4.66 | 4.66 |
| 557.79 | 4.97 | 4.97 |
| 568.77 | 4.53 | 4.53 |
| 552.75 | 4.30 | 4.30 |
| 551.76 | 4.90 | 4.90 |
| 527.70 | 2.94 | 2.94 |
| 593.84 | 5.94 | 5.94 |
| 515.73 | 4.34 | 4.34 |
| 501.70 | 3.81 | 3.81 |
| 489.69 | 3.80 | 3.80 |
| 644.75 | 5.56 | 5.56 |
| 644.75 | 5.42 | 5.42 |
| 644.75 | 5.42 | 5.42 |
| 644.75 | 5.56 | 5.56 |
| 650.78 | 5.46 | 5.46 |
| 610.71 | 4.68 | 4.68 |
| 597.67 | 4.34 | 4.34 |
| 581.67 | 4.63 | 4.63 |
| 606.82 | 5.33 | 5.33 |
| 620.85 | 5.35 | 5.35 |
| 620.85 | 5.57 | 5.57 |
| 632.86 | 5.72 | 5.72 |
| 604.81 | 5.08 | 5.08 |
| 632.86 | 5.86 | 5.86 |
| 617.81 | 4.83 | 4.83 |
| 608.79 | 3.91 | 3.91 |
| 622.82 | 4.57 | 4.57 |
| 662.89 | 5.35 | 5.35 |
| 644.75 | 5.56 | 5.56 |
| 637.73 | 6.10 | 6.10 |
| 637.73 | 6.10 | 6.10 |
| 650.78 | 5.62 | 5.62 |
| 624.86 | 5.56 | 5.56 |
| 632.84 | 5.76 | 5.76 |
| 632.77 | 3.76 | 3.76 |
| 568.68 | 2.57 | 2.57 |
| 652.79 | 5.85 | 5.85 |