Basic Information
ID: ALA2169431
Type: ADME
Description: Inhibition of human liver OATP2B1 expressed in HEK293 Flp-In cells assessed as reduction in [3H]E3S uptake at 20 uM incubated for 5 mins by scintillation counting
Organism: Homo sapiens
Cell type: HEK293
Activity Charts
Bioactivity
Activity Types for Assay ALA2169431
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 383.41 | 1.78 | 1.78 |
| 162.24 | 1.85 | 1.85 |
| 361.37 | 1.54 | 1.54 |
| 357.79 | 3.93 | 3.93 |
| 280.42 | 3.88 | 3.88 |
| 284.75 | 3.15 | 3.15 |
| 267.37 | 1.61 | 1.61 |
| 268.36 | 4.83 | 4.83 |
| 252.27 | 1.77 | 1.77 |
| 216.19 | 2.55 | 2.55 |
| 290.32 | 1.26 | 1.26 |
| 454.61 | 5.09 | 5.09 |
| 398.40 | 3.70 | 3.70 |
| 146.14 | 1.79 | 1.79 |
| 414.53 | 3.37 | 3.37 |
| 266.34 | 0.45 | 0.45 |
| 259.35 | 2.58 | 2.58 |
| 334.40 | 0.86 | 0.86 |
| 252.35 | 0.60 | 0.60 |
| 330.75 | 1.89 | 1.89 |
| 232.24 | 0.70 | 0.70 |
| 309.33 | 4.44 | 4.44 |
| 270.24 | 2.58 | 2.58 |
| 250.34 | 3.57 | 3.57 |
| 293.37 | 3.13 | 3.13 |
| 254.24 | 2.87 | 2.87 |
| 385.51 | 2.09 | 2.09 |
| 302.24 | 1.99 | 1.99 |
| 194.19 | 0.08 | 0.08 |
| 444.49 | -0.14 | -0.14 |
| 137.14 | -0.31 | -0.31 |
| 272.26 | 2.51 | 2.51 |
| 130.25 | 1.88 | 1.88 |
| 272.37 | 1.09 | 1.09 |
| 494.01 | 3.64 | 3.64 |
| 441.58 | 1.98 | 1.98 |
| 370.59 | 5.89 | 5.89 |
| 369.37 | 3.52 | 3.52 |
| 586.69 | 4.09 | 4.09 |
| 287.22 | -0.05 | -0.05 |
| 318.87 | 4.89 | 4.89 |
| 266.39 | 3.53 | 3.53 |
| 319.88 | 4.81 | 4.81 |
| 329.37 | 3.33 | 3.33 |
| 371.52 | 6.00 | 6.00 |
| 421.45 | 1.85 | 1.85 |
| 853.92 | 3.74 | 3.74 |
| 248.33 | 1.91 | 1.91 |
| 404.55 | 4.20 | 4.20 |
| 136.15 | 0.44 | 0.44 |
| 339.48 | 3.36 | 3.36 |
| 332.34 | 3.43 | 3.43 |
| 348.38 | 3.72 | 3.72 |
| 206.28 | 3.07 | 3.07 |
| 331.35 | 1.58 | 1.58 |
| 308.38 | 3.79 | 3.79 |
| 733.94 | 1.79 | 1.79 |
| 314.47 | 4.72 | 4.72 |
| 344.85 | 5.38 | 5.38 |
| 306.28 | 0.74 | 0.74 |
| 399.44 | 2.87 | 2.87 |
| 393.44 | 3.41 | 3.41 |
| 236.27 | 3.39 | 3.39 |
| 144.21 | 2.29 | 2.29 |
| 515.10 | 6.48 | 6.48 |
| 194.19 | -1.03 | -1.03 |
| 179.22 | 2.04 | 2.04 |
| 238.16 | 0.07 | 0.07 |
| 376.45 | 1.60 | 1.60 |
| 670.86 | 3.09 | 3.09 |
| 613.80 | 2.87 | 2.87 |
| 567.80 | 4.75 | 4.75 |
| 505.64 | 2.40 | 2.40 |
| 381.38 | 3.51 | 3.51 |
| 471.69 | 6.45 | 6.45 |
| 356.45 | 3.16 | 3.16 |
| 336.48 | 4.14 | 4.14 |
| 357.44 | 2.49 | 2.49 |
| 470.02 | 3.55 | 3.55 |
| 277.41 | 4.17 | 4.17 |
| 267.24 | -0.20 | -0.20 |
| 235.33 | 1.34 | 1.34 |
| 255.36 | 3.72 | 3.72 |
| 360.45 | 1.56 | 1.56 |
| 343.22 | 4.23 | 4.23 |
| 325.77 | 4.32 | 4.32 |
| 272.39 | 3.61 | 3.61 |
| 151.25 | 1.91 | 1.91 |
| 189.22 | 0.16 | 0.16 |
| 360.84 | 4.68 | 4.68 |
| 296.15 | 4.36 | 4.36 |
| 451.48 | 1.72 | 1.72 |
| 628.81 | 4.33 | 4.33 |
| 256.10 | 2.01 | 2.01 |
| 308.38 | 0.53 | 0.53 |
| 302.24 | 1.99 | 1.99 |
| 608.69 | 4.17 | 4.17 |
| 268.22 | 3.10 | 3.10 |
| 270.35 | 1.78 | 1.78 |
| 612.63 | 3.63 | 3.63 |
| 454.45 | 0.27 | 0.27 |
| 276.21 | 3.21 | 3.21 |
| 318.34 | 3.20 | 3.20 |
| 263.79 | 3.96 | 3.96 |
| 477.05 | 5.09 | 5.09 |
| 261.37 | 3.42 | 3.42 |
| 458.58 | 5.35 | 5.35 |
| 218.26 | 1.47 | 1.47 |
| 336.37 | 3.10 | 3.10 |
| 588.56 | 1.34 | 1.34 |
| 810.99 | 3.99 | 3.99 |
| 1202.63 | ||
| 247.25 | -0.46 | -0.46 |
| 239.75 | 3.30 | 3.30 |
| 271.40 | 3.38 | 3.38 |
| 285.37 | 2.20 | 2.20 |
| 543.53 | 0.00 | 0.00 |
| 315.87 | 5.19 | 5.19 |
| 434.53 | 4.60 | 4.60 |
| 501.67 | 5.51 | 5.51 |
| 504.64 | -0.02 | -0.02 |
| 720.96 | 5.91 | 5.91 |
| 296.55 | 3.62 | 3.62 |
| 705.65 | 5.58 | 5.58 |
| 382.89 | 4.89 | 4.89 |
| 388.90 | 3.15 | 3.15 |
| 170.24 | 2.18 | 2.18 |
| 94.14 | 0.51 | 0.51 |
| 440.46 | 4.03 | 4.03 |
| 514.63 | 7.26 | 7.26 |
| 172.18 | -0.98 | -0.98 |
| 418.57 | 4.59 | 4.59 |
| 435.53 | 4.16 | 4.16 |
| 268.74 | 1.40 | 1.40 |
| 445.55 | 2.08 | 2.08 |
| 824.97 | 3.52 | 3.52 |
| 314.37 | 2.26 | 2.26 |
| 1143.29 | ||
| 409.43 | 4.89 | 4.89 |
| 424.53 | 2.44 | 2.44 |
| 462.51 | -0.23 | -0.23 |
| 704.87 | 4.21 | 4.21 |
| 405.50 | 1.24 | 1.24 |
| 452.56 | 4.92 | 4.92 |
| 452.60 | 5.22 | 5.22 |
| 163.24 | 2.33 | 2.33 |
| 324.42 | 3.17 | 3.17 |
| 531.44 | 4.21 | 4.21 |
| 324.42 | 3.17 | 3.17 |
| 272.39 | 3.26 | 3.26 |
| 205.26 | 0.24 | 0.24 |
| 161.20 | -1.81 | -1.81 |
| 324.34 | -0.80 | -0.80 |
| 430.54 | 2.72 | 2.72 |
| 169.57 | 1.77 | 1.77 |
| 499.71 | 3.40 | 3.40 |
| 416.58 | 4.85 | 4.85 |
| 427.55 | 2.31 | 2.31 |
| 408.58 | 3.45 | 3.45 |
| 822.94 | 2.25 | 2.25 |
| 288.43 | 3.88 | 3.88 |
| 822.95 | 4.34 | 4.34 |
| 392.47 | 1.90 | 1.90 |
| 225.21 | -1.33 | -1.33 |
| 129.17 | -1.03 | -1.03 |
| 602.68 | 7.33 | 7.33 |
| 584.66 | -1.51 | -1.51 |
| 444.44 | -0.21 | -0.21 |
| 515.71 | 2.37 | 2.37 |
| 424.09 | 5.46 | 5.46 |
| 315.68 | 4.07 | 4.07 |
| 180.17 | -1.04 | -1.04 |
| 563.65 | 5.56 | 5.56 |
| 308.33 | 3.61 | 3.61 |
| 136.11 | 0.06 | 0.06 |
| 697.78 | 4.75 | 4.75 |
| 459.56 | 4.88 | 4.88 |
| 384.26 | 3.96 | 3.96 |
| 479.53 | 3.68 | 3.68 |
| 474.59 | 1.61 | 1.61 |
| 558.65 | 6.31 | 6.31 |
| 315.46 | 5.56 | 5.56 |
| 481.55 | 2.40 | 2.40 |
| 346.34 | 2.18 | 2.18 |
| 383.38 | 2.88 | 2.88 |
| 345.42 | 2.90 | 2.90 |
| 382.53 | 3.82 | 3.82 |
| 260.25 | 0.37 | 0.37 |
| 449.63 | 3.59 | 3.59 |
| 465.63 | 2.56 | 2.56 |
| 449.63 | 3.59 | 3.59 |
| 499.71 | 3.40 | 3.40 |
| 483.72 | 4.43 | 4.43 |
| 580.54 | -1.17 | -1.17 |
| 926.11 | 0.94 | 0.94 |
| 217.29 | 0.63 | 0.63 |
| 446.36 | 0.14 | 0.14 |
| 645.61 | -8.56 | -8.56 |
| 469.58 | 3.64 | 3.64 |
| 838.00 | 5.10 | 5.10 |
| 769.54 | 5.29 | 5.29 |
| 774.85 | -3.62 | -3.62 |
| 776.87 | 4.56 | 4.56 |
| 392.33 | 5.18 | 5.18 |
| 218.34 | 3.90 | 3.90 |
| 363.39 | 0.15 | 0.15 |
| 350.44 | 3.29 | 3.29 |
| 460.39 | 3.80 | 3.80 |
| 371.39 | 2.58 | 2.58 |
| 747.96 | 2.44 | 2.44 |
| 780.95 | 2.22 | 2.22 |
| 211.27 | 1.80 | 1.80 |
| 1214.65 | ||
| 1736.18 | ||
| 558.60 | 4.17 | 4.17 |
| 753.00 | 8.71 | 8.71 |
| 421.47 | 4.52 | 4.52 |
| 429.60 | 5.41 | 5.41 |
| 527.52 | -7.27 | -7.27 |
| 448.51 | 1.53 | 1.53 |
| 411.47 | 4.63 | 4.63 |
| 339.46 | 3.32 | 3.32 |
| 266.39 |