Assay Report Card

Basic Information

ID: ALA2174991

Type: Binding

Description: Inhibition of human recombinant N-terminal His6-tagged AKR1C4 expressed in Escherichia coli BL21(DE3) cells using 8-Acetyl-2,3,5,6-tetrahydro-1H,4H-11-oxa-3a-aza-benzo[de]anthracen-10-one as substrate after 1 hr by fluorimetric analysis

Organism: Homo sapiens

Activity Charts

Bioactivity

Activity Types for Assay ALA2174991

IC50

Total(74)

Compound Summary

Parent Molecular Weight	ALogP	Polar Surface Area
357.79	3.93	3.93
296.15	4.74	4.74
244.26	3.68	3.68
281.23	4.15	4.15
230.26	3.04	3.04
206.28	3.07	3.07
303.34	2.09	2.09
317.37	2.13	2.13
317.37	2.13	2.13
305.36	1.91	1.91
379.87	3.49	3.49
379.87	3.49	3.49
369.44	3.48	3.48
421.52	4.51	4.51
360.39	1.46	1.46
341.40	1.61	1.61
316.38	1.53	1.53
386.47	1.91	1.91
402.54	2.62	2.62
387.51	1.73	1.73
330.41	1.79	1.79
344.44	2.14	2.14
398.48	1.91	1.91
421.52	2.80	2.80
356.45	2.56	2.56
319.38	2.33	2.33
319.38	2.33	2.33
305.36	1.94	1.94
302.31	1.97	1.97
385.41	1.31	1.31
362.36	2.04	2.04
335.36	2.27	2.27
351.81	2.79	2.79
396.26	2.89	2.89
443.26	2.74	2.74
342.38	2.00	2.00
347.39	2.14	2.14
351.81	2.79	2.79
377.42	2.15	2.15
318.35	1.53	1.53
323.35	2.04	2.04
339.80	2.56	2.56
339.80	2.56	2.56
335.38	1.91	1.91
335.38	1.91	1.91
397.45	3.70	3.70
319.38	2.21	2.21
319.38	2.21	2.21
317.37	2.53	2.53
327.36	3.34	3.34
380.22	3.34	3.34
331.39	2.69	2.69
331.39	2.52	2.52
332.38	1.71	1.71
362.36	2.04	2.04
351.81	2.79	2.79
396.26	2.89	2.89
443.26	2.74	2.74
333.37	1.84	1.84
347.39	2.14	2.14
331.39	2.44	2.44
362.36	2.04	2.04
342.38	2.00	2.00
351.81	2.79	2.79
396.26	2.89	2.89
443.26	2.74	2.74
333.37	1.84	1.84
347.39	2.14	2.14
331.39	2.44	2.44
341.39	2.11	2.11
501.48	4.43	4.43
267.31	1.34	1.34
323.40	2.19	2.19
303.34	2.14	2.14