Basic Information
ID: ALA2185131
Type: Functional
Description: Inhibition of PI3Kalpha in PTEN deficient human U87MG cells xenografted in NCr nude mouse assessed as reduction in S6RP phosphorylation at 10 mg/kg, po qd for 24 days measured 1 to 4 hrs post last dose by electrochemiluminescence assay
Format: BAO_0000218
Organism: Mus musculus
Strain: NCr
Cell type: U-87MG ATCC
Target: Mus musculus(ALA375)
Document: ALA2177093
Inhibition of PI3Kalpha in PTEN deficient human U87MG cells xenografted in NCr nude mouse assessed as reduction in S6RP phosphorylation at 10 mg/kg, po qd for 24 days measured 1 to 4 hrs post last dose by electrochemiluminescence assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA2185131
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 386.48 | 2.45 | 2.45 |
| 414.49 | 1.75 | 1.75 |