Basic Information
ID: ALA2212885
Type: Binding
Description: Inhibition of gamma secretase in human H4 cells expressing APP695 assessed as inhibition of Abeta42 production after 20 to 24 hrs by liquid phase electrochemiluminescence assay
Format: BAO_0000219
Organism: Homo sapiens
Cell type: H4
Target: Gamma-secretase(ALA2094135)
Document: ALA2203085
Inhibition of gamma secretase in human H4 cells expressing APP695 assessed as inhibition of Abeta42 production after 20 to 24 hrs by liquid phase electrochemiluminescence assay: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA2212885
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 398.48 | 3.33 | 3.33 |
| 466.54 | 4.35 | 4.35 |
| 381.82 | 3.36 | 3.36 |
| 342.83 | 3.77 | 3.77 |
| 370.88 | 4.55 | 4.55 |
| 338.79 | 4.52 | 4.52 |
| 384.86 | 3.54 | 3.54 |
| 429.50 | 5.06 | 5.06 |
| 372.85 | 3.78 | 3.78 |
| 400.91 | 4.56 | 4.56 |
| 368.82 | 4.52 | 4.52 |
| 372.85 | 3.78 | 3.78 |
| 386.84 | 5.28 | 5.28 |
| 419.86 | 5.20 | 5.20 |
| 386.84 | 5.28 | 5.28 |
| 427.89 | 6.12 | 6.12 |
| 368.44 | 5.66 | 5.66 |
| 363.82 | 3.24 | 3.24 |
| 365.82 | 4.34 | 4.34 |
| 358.83 | 5.48 | 5.48 |
| 324.38 | 4.82 | 4.82 |
| 348.23 | 4.84 | 4.84 |
| 271.70 | 3.54 | 3.54 |
| 285.73 | 3.84 | 3.84 |
| 327.81 | 5.01 | 5.01 |