Basic Information
ID: ALA2214954
Type: Binding
Description: Inhibition of MDR1 transfected in MDCK2 cells assessed as increase in calcein AM uptake incubated for 30 mins prior to calcein AM influx measured after 20 mins by fluorimetric analysis
Format: BAO_0000219
Cell type: MDCK-II
Target: P-glycoprotein 1(ALA4302)
Document: ALA2203082
Inhibition of MDR1 transfected in MDCK2 cells assessed as increase in calcein AM uptake incubated for 30 mins prior to calcein AM influx measured after 20 mins by fluorimetric analysis: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA2214954
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 637.72 | 5.99 | 5.99 |
| 689.80 | 6.63 | 6.63 |
| 609.64 | 5.31 | 5.31 |
| 625.71 | 5.85 | 5.85 |
| 621.65 | 5.46 | 5.46 |
| 661.72 | 5.95 | 5.95 |
| 677.79 | 6.48 | 6.48 |
| 673.73 | 6.09 | 6.09 |
| 663.73 | 6.37 | 6.37 |
| 679.80 | 6.90 | 6.90 |
| 675.74 | 6.51 | 6.51 |
| 691.81 | 7.05 | 7.05 |