Basic Information
ID: ALA2320373
Type: Functional
Description: Positive allosteric modulation of human muscarinic M4 receptor expressed in CHO-K1 cells assessed as leftward shift in acetylcholine response treated for 144 secs prior to acetylcholine addition measured for 5 mins by Fluo-4-AM based calcium mobilization assay
Organism: Homo sapiens
Cell type: CHO-K1
Activity Charts
Bioactivity
Activity Types for Assay ALA2320373
EC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 440.48 | 4.37 | 4.37 |
| 341.44 | 3.43 | 3.43 |
| 346.84 | 3.47 | 3.47 |
| 337.88 | 4.21 | 4.21 |
| 339.85 | 3.06 | 3.06 |
| 311.84 | 3.68 | 3.68 |
| 327.84 | 2.92 | 2.92 |
| 366.92 | 3.36 | 3.36 |
| 351.90 | 4.46 | 4.46 |
| 375.88 | 4.09 | 4.09 |
| 381.84 | 4.36 | 4.36 |
| 295.80 | 3.04 | 3.04 |
| 360.87 | 4.03 | 4.03 |
| 360.87 | 3.78 | 3.78 |
| 346.84 | 3.47 | 3.47 |
| 360.87 | 4.03 | 4.03 |
| 346.84 | 3.47 | 3.47 |
| 360.87 | 4.03 | 4.03 |
| 360.87 | 3.52 | 3.52 |
| 360.87 | 3.52 | 3.52 |
| 360.87 | 3.52 | 3.52 |
| 347.83 | 2.87 | 2.87 |
| 347.83 | 2.87 | 2.87 |
| 347.83 | 2.87 | 2.87 |
| 347.83 | 2.87 | 2.87 |
| 389.86 | 3.81 | 3.81 |
| 345.86 | 4.08 | 4.08 |
| 381.84 | 4.36 | 4.36 |
| 380.30 | 4.73 | 4.73 |
| 359.88 | 4.39 | 4.39 |
| 380.30 | 4.73 | 4.73 |
| 352.87 | 3.54 | 3.54 |
| 413.85 | 5.10 | 5.10 |
| 388.92 | 4.14 | 4.14 |
| 361.85 | 4.41 | 4.41 |
| 375.88 | 4.80 | 4.80 |
| 325.82 | 2.67 | 2.67 |
| 311.79 | 2.28 | 2.28 |
| 297.81 | 3.29 | 3.29 |