Basic Information
ID: ALA2343087
Type: Binding
Description: Inhibition of SHIP2 in mouse 3T3L1 cells assessed as reduction of TNF-alpha induced decrease in insulin-stimulated Akt phosphorylation at Thr308 at 10 uM treated for 15 mins after TNF alpha challenge for 16 hrs and prior to insulin stimulation measured after 2 hrs by Western blot analysis
Organism: Mus musculus
Cell type: 3T3-L1
Activity Charts
Bioactivity
Activity Types for Assay ALA2343087
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 380.88 | 5.02 | 5.02 |
| 366.85 | 4.63 | 4.63 |
| 386.37 | 4.40 | 4.40 |
| 364.42 | 4.51 | 4.51 |
| 386.37 | 4.40 | 4.40 |
| 388.80 | 4.77 | 4.77 |
| 366.85 | 4.89 | 4.89 |
| 420.82 | 5.51 | 5.51 |
| 336.37 | 3.98 | 3.98 |
| 354.36 | 4.12 | 4.12 |
| 372.35 | 4.26 | 4.26 |
| 346.43 | 4.37 | 4.37 |