ID: ALA2350637
Type: Binding
Description: Competitive inhibition of human recombinant DOT1L (1 to 420 amino acid residues) overexpressed in Escherichia coli BL21 (DE3) using [3H]-SAM as substrate assessed as inhibition of nucleosome methylation incubated for 30 mins prior to substrate addition measured after 1 hr by scintillation counting analysis
Organism: Homo sapiens
Bioactivity
Activity Types for Assay ALA2350637
Ki
Parent Molecular Weight | ALogP | Polar Surface Area |
---|---|---|
384.42 | -1.44 | -1.44 |
392.15 | -0.77 | -0.77 |
462.33 | -0.07 | -0.07 |