Basic Information
ID: ALA2354281
Type: Functional
Description: PubChem BioAssay. Counterscreen for inhibitors of T-cell receptor (TCR)-CD3 interaction: Fluorescence-based biochemical high throughput dose response assay to identify inhibitors of T-cell receptor (TCR)-CD3 interaction using a TAMRA-labeled BSA probe. (Class of assay: confirmatory)
Activity Charts
Bioactivity
Activity Types for Assay ALA2354281
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 272.26 | 1.17 | 1.17 |
| 184.15 | 0.59 | 0.59 |
| 220.18 | 1.02 | 1.02 |
| 282.30 | 2.23 | 2.23 |
| 376.87 | 1.84 | 1.84 |
| 350.83 | 1.70 | 1.70 |
| 287.31 | 1.94 | 1.94 |
| 234.17 | 1.55 | 1.55 |
| 397.42 | 1.89 | 1.89 |
| 302.24 | 1.99 | 1.99 |
| 323.31 | 1.31 | 1.31 |
| 336.35 | 2.63 | 2.63 |
| 475.53 | 2.96 | 2.96 |
| 459.53 | 3.25 | 3.25 |
| 383.43 | 1.74 | 1.74 |
| 281.27 | 1.87 | 1.87 |
| 385.38 | 3.96 | 3.96 |
| 276.72 | 2.72 | 2.72 |
| 308.49 | 3.38 | 3.38 |
| 589.07 | 3.93 | 3.93 |
| 353.38 | 3.36 | 3.36 |
| 385.45 | 3.36 | 3.36 |
| 369.42 | 2.75 | 2.75 |
| 293.39 | 2.25 | 2.25 |
| 246.23 | -0.34 | -0.34 |
| 364.40 | 3.52 | 3.52 |
| 542.61 | 5.25 | 5.25 |
| 236.30 | 1.10 | 1.10 |
| 547.64 | 4.38 | 4.38 |
| 369.42 | 1.88 | 1.88 |
| 441.53 | 2.75 | 2.75 |
| 406.24 | 1.74 | 1.74 |
| 267.24 | 3.33 | 3.33 |
| 458.52 | 2.54 | 2.54 |
| 581.69 | 5.16 | 5.16 |
| 355.33 | 1.46 | 1.46 |
| 295.68 | 0.65 | 0.65 |
| 351.36 | 3.02 | 3.02 |
| 427.44 | 1.90 | 1.90 |
| 365.39 | 3.33 | 3.33 |
| 471.46 | 2.27 | 2.27 |
| 427.51 | 2.44 | 2.44 |
| 460.52 | 4.22 | 4.22 |
| 268.22 | 3.10 | 3.10 |
| 428.26 | 2.01 | 2.01 |
| 316.34 | 0.74 | 0.74 |
| 561.73 | 3.55 | 3.55 |
| 365.39 | 3.41 | 3.41 |
| 443.51 | 2.06 | 2.06 |
| 403.46 | 1.25 | 1.25 |
| 323.33 | 2.69 | 2.69 |
| 439.88 | 1.14 | 1.14 |
| 446.44 | 1.05 | 1.05 |
| 428.47 | 2.30 | 2.30 |
| 455.49 | 2.30 | 2.30 |
| 381.43 | 3.64 | 3.64 |
| 357.32 | 3.29 | 3.29 |
| 436.56 | 4.68 | 4.68 |
| 356.37 | -0.72 | -0.72 |
| 212.20 | -0.77 | -0.77 |
| 455.56 | 3.14 | 3.14 |
| 318.76 | 2.64 | 2.64 |
| 347.42 | 4.26 | 4.26 |
| 378.39 | 3.57 | 3.57 |
| 321.38 | 1.40 | 1.40 |
| 366.37 | 2.39 | 2.39 |
| 351.36 | 3.02 | 3.02 |
| 407.46 | 3.49 | 3.49 |
| 390.38 | 1.26 | 1.26 |
| 245.27 | 1.15 | 1.15 |
| 318.33 | 1.17 | 1.17 |
| 381.39 | 3.03 | 3.03 |
| 274.24 | 2.44 | 2.44 |
| 370.32 | 0.38 | 0.38 |
| 367.32 | 2.64 | 2.64 |
| 340.77 | 3.27 | 3.27 |
| 301.33 | 1.92 | 1.92 |
| 411.44 | 3.61 | 3.61 |
| 349.30 | -0.46 | -0.46 |
| 397.41 | 1.89 | 1.89 |
| 381.39 | 2.65 | 2.65 |
| 568.45 | 4.71 | 4.71 |
| 335.36 | 3.32 | 3.32 |
| 402.45 | 3.64 | 3.64 |
| 327.38 | 2.82 | 2.82 |
| 336.35 | 2.63 | 2.63 |
| 335.41 | 1.71 | 1.71 |
| 312.35 | 2.68 | 2.68 |
| 429.46 | 2.14 | 2.14 |
| 304.30 | 4.02 | 4.02 |
| 432.87 | 3.51 | 3.51 |
| 314.37 | 1.34 | 1.34 |
| 359.22 | 3.52 | 3.52 |
| 331.33 | 3.19 | 3.19 |
| 356.38 | 2.21 | 2.21 |
| 391.43 | 2.57 | 2.57 |
| 381.46 | 2.31 | 2.31 |
| 314.37 | 0.96 | 0.96 |
| 320.35 | 2.93 | 2.93 |
| 363.40 | 3.49 | 3.49 |
| 461.27 | 2.76 | 2.76 |
| 371.37 | 3.29 | 3.29 |
| 378.39 | 3.92 | 3.92 |
| 480.47 | 1.57 | 1.57 |
| 455.47 | 2.98 | 2.98 |
| 447.32 | 5.50 | 5.50 |
| 251.31 | 0.65 | 0.65 |
| 408.41 | 1.57 | 1.57 |
| 304.30 | 4.02 | 4.02 |
| 432.41 | 1.45 | 1.45 |
| 360.35 | 1.25 | 1.25 |
| 276.72 | 2.72 | 2.72 |
| 384.38 | 2.07 | 2.07 |
| 335.36 | 3.32 | 3.32 |
| 305.38 | 1.70 | 1.70 |
| 349.39 | 3.57 | 3.57 |
| 330.37 | 1.04 | 1.04 |
| 385.28 | 2.35 | 2.35 |
| 417.47 | 3.33 | 3.33 |
| 374.42 | 1.82 | 1.82 |
| 447.56 | 2.90 | 2.90 |
| 405.82 | 3.94 | 3.94 |
| 349.39 | 3.57 | 3.57 |
| 339.33 | 3.15 | 3.15 |
| 320.35 | 2.93 | 2.93 |
| 390.42 | 1.96 | 1.96 |
| 354.32 | 0.68 | 0.68 |
| 394.39 | 0.83 | 0.83 |
| 464.51 | 3.24 | 3.24 |
| 395.41 | 4.01 | 4.01 |
| 459.57 | 2.49 | 2.49 |
| 374.38 | 1.55 | 1.55 |
| 461.54 | 5.13 | 5.13 |
| 385.28 | 2.35 | 2.35 |
| 457.46 | 1.91 | 1.91 |
| 432.38 | 0.09 | 0.09 |
| 421.43 | 2.39 | 2.39 |
| 277.35 | 0.54 | 0.54 |
| 290.24 | 0.84 | 0.84 |
| 406.19 | 2.81 | 2.81 |
| 288.35 | 3.08 | 3.08 |
| 234.28 | 2.07 | 2.07 |
| 308.36 | 2.66 | 2.66 |
| 359.36 | 4.40 | 4.40 |
| 454.24 | 3.64 | 3.64 |
| 389.24 | 0.54 | 0.54 |
| 194.22 | 0.62 | 0.62 |
| 415.45 | 3.84 | 3.84 |
| 431.51 | 1.87 | 1.87 |
| 521.58 | 5.11 | 5.11 |
| 452.10 | 4.09 | 4.09 |
| 331.30 | 0.72 | 0.72 |
| 385.23 | 3.93 | 3.93 |
| 399.21 | 1.23 | 1.23 |
| 327.34 | 0.89 | 0.89 |
| 417.49 | 1.56 | 1.56 |
| 452.85 | 4.28 | 4.28 |
| 316.39 | 1.05 | 1.05 |
| 246.22 | 1.45 | 1.45 |
| 185.19 | 1.99 | 1.99 |
| 272.26 | 1.96 | 1.96 |
| 384.78 | 3.57 | 3.57 |
| 330.77 | 2.98 | 2.98 |
| 552.66 | 3.93 | 3.93 |
| 397.46 | 3.21 | 3.21 |
| 366.37 | 2.64 | 2.64 |
| 338.32 | 2.51 | 2.51 |
| 359.39 | 3.51 | 3.51 |
| 406.39 | 3.09 | 3.09 |
| 545.53 | ||
| 403.41 | 4.00 | 4.00 |
| 470.53 | 5.21 | 5.21 |
| 427.37 | 1.73 | 1.73 |
| 397.61 | 3.30 | 3.30 |
| 222.15 | 0.47 | 0.47 |
| 368.35 | 2.19 | 2.19 |
| 331.28 | 1.87 | 1.87 |
| 499.96 | 2.30 | 2.30 |
| 380.36 | 2.93 | 2.93 |
| 538.63 | 3.54 | 3.54 |
| 404.39 | 1.76 | 1.76 |
| 330.30 | 1.18 | 1.18 |
| 412.08 | 3.61 | 3.61 |
| 444.45 | 4.09 | 4.09 |
| 360.38 | 2.73 | 2.73 |
| 310.31 | 2.52 | 2.52 |
| 577.71 | 5.21 | 5.21 |
| 336.35 | 2.63 | 2.63 |
| 536.16 | 4.38 | 4.38 |
| 390.23 | 4.43 | 4.43 |
| 294.31 | 3.60 | 3.60 |
| 273.25 | 0.96 | 0.96 |
| 488.95 | 3.95 | 3.95 |
| 429.23 | 3.68 | 3.68 |
| 437.09 | 3.82 | 3.82 |
| 279.32 | 1.39 | 1.39 |
| 449.49 | 0.91 | 0.91 |
| 377.19 | 2.96 | 2.96 |
| 481.14 | 3.81 | 3.81 |
| 500.10 | 2.71 | 2.71 |
| 248.33 | 2.69 | 2.69 |
| 486.44 | 2.57 | 2.57 |
| 324.34 | 2.21 | 2.21 |
| 397.34 | 2.24 | 2.24 |
| 384.44 | 1.47 | 1.47 |
| 494.52 | 3.04 | 3.04 |
| 291.29 | 2.13 | 2.13 |
| 323.33 | 1.63 | 1.63 |
| 426.84 | 4.27 | 4.27 |
| 363.71 | 2.45 | 2.45 |
| 436.45 | 3.28 | 3.28 |
| 304.33 | 1.52 | 1.52 |
| 416.39 | 3.47 | 3.47 |
| 445.18 | 3.68 | 3.68 |
| 524.65 | 4.01 | 4.01 |
| 367.07 | 2.35 | 2.35 |
| 382.42 | 4.15 | 4.15 |
| 408.21 | 2.76 | 2.76 |
| 468.88 | 1.74 | 1.74 |
| 534.00 | 3.56 | 3.56 |
| 402.25 | 3.05 | 3.05 |
| 388.43 | 3.15 | 3.15 |
| 322.31 | 0.43 | 0.43 |
| 323.70 | 1.75 | 1.75 |
| 427.44 | 1.90 | 1.90 |
| 447.46 | 1.73 | 1.73 |
| 374.35 | 2.19 | 2.19 |
| 481.45 | 3.19 | 3.19 |
| 346.30 | 1.48 | 1.48 |
| 426.46 | 2.42 | 2.42 |
| 357.32 | 1.90 | 1.90 |
| 471.47 | 4.14 | 4.14 |