Basic Information
ID: ALA2363031
Type: Functional
Description: MMV: Motility assay. Percent change (relative to DMSO controls) @ 5 uM of movement of 4-5 Schistosoma mansoni adult males after 72 h as measured by the Consensus Voting Luminance Difference algorithm available on WormAssay (PMID:22303493). Occasional incongruence ocurrs between the motility scores and the visually adjudicated 'toxicity scores'. In these cases the 'toxicity score' should be prioritized. Only those Malaria box 'Drug-like' cpds yielding the most severe phenotypes vs. somules were tested. Caffrey group UCSF.
Organism: Schistosoma mansoni
Activity Charts
Bioactivity
Activity Types for Assay ALA2363031
Motility
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 291.40 | 3.88 | 3.88 |
| 347.26 | 3.78 | 3.78 |
| 298.77 | 4.95 | 4.95 |
| 367.28 | 3.70 | 3.70 |
| 249.75 | 2.91 | 2.91 |
| 479.85 | 3.90 | 3.90 |
| 398.51 | 5.20 | 5.20 |
| 497.75 | 4.59 | 4.59 |
| 354.47 | 4.02 | 4.02 |
| 384.50 | 4.03 | 4.03 |
| 418.59 | 4.27 | 4.27 |
| 328.17 | 4.12 | 4.12 |
| 413.52 | 5.59 | 5.59 |
| 354.41 | 4.46 | 4.46 |
| 420.18 | 4.45 | 4.45 |
| 480.01 | 5.37 | 5.37 |
| 388.52 | 4.85 | 4.85 |
| 373.41 | 4.50 | 4.50 |
| 457.83 | 4.30 | 4.30 |
| 356.43 | 4.99 | 4.99 |
| 496.50 | 5.20 | 5.20 |
| 460.54 | 6.38 | 6.38 |
| 232.71 | 3.49 | 3.49 |
| 287.32 | 1.31 | 1.31 |
| 362.27 | 3.63 | 3.63 |
| 469.31 | 3.61 | 3.61 |
| 368.91 | 5.09 | 5.09 |
| 366.89 | 3.95 | 3.95 |
| 310.42 | 4.85 | 4.85 |
| 360.24 | 4.22 | 4.22 |
| 333.58 | 5.43 | 5.43 |
| 355.95 | 3.72 | 3.72 |
| 425.96 | 4.84 | 4.84 |
| 315.68 | 4.32 | 4.32 |
| 416.29 | 4.16 | 4.16 |
| 308.43 | 3.69 | 3.69 |
| 384.50 | 3.67 | 3.67 |
| 341.33 | 0.31 | 0.31 |
| 401.51 | 4.70 | 4.70 |
| 465.47 | 4.32 | 4.32 |