Basic Information
ID: ALA2388954
Type: ADME
Description: Reversible inhibition of CYP3A4/5 in human liver microsomes using midazolam as substrate preincubated for 30 mins followed by NADPH and substrate addition measured after 10 mins
Format: BAO_0000251
Organism: Homo sapiens
Tissue: Liver
Subcellular Fraction: Microsome
Target: Cytochrome P450 3A4/3A5(ALA2111472)
Document: ALA2384944
Reversible inhibition of CYP3A4/5 in human liver microsomes using midazolam as substrate preincubated for 30 mins followed by NADPH and substrate addition measured after 10 mins: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA2388954
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 229.30 | 4.19 | 4.19 |
| 281.25 | 4.48 | 4.48 |
| 236.32 | 3.92 | 3.92 |
| 250.30 | 2.91 | 2.91 |
| 222.29 | 3.74 | 3.74 |
| 288.27 | 4.21 | 4.21 |
| 322.33 | 4.65 | 4.65 |
| 374.28 | 4.95 | 4.95 |