Basic Information
ID: ALA2390624
Type: Functional
Description: Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding preincubated for 1 hr followed by 50 nM PGD2 and 0.1 nM [35S]-GTPgammaS addition measured after 2 hrs by liquid scintillation counting analysis
Organism: Homo sapiens
Cell type: CHO-K1
Activity Charts
Bioactivity
Activity Types for Assay ALA2390624
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 348.38 | 4.31 | 4.31 |
| 472.54 | 2.27 | 2.27 |
| 413.50 | 2.78 | 2.78 |
| 460.56 | 4.93 | 4.93 |
| 439.54 | 3.34 | 3.34 |
| 480.97 | 5.02 | 5.02 |
| 447.52 | 3.76 | 3.76 |
| 386.43 | 1.99 | 1.99 |
| 419.43 | 4.80 | 4.80 |
| 325.34 | 3.07 | 3.07 |
| 405.40 | 4.49 | 4.49 |
| 437.42 | 4.94 | 4.94 |
| 435.43 | 4.50 | 4.50 |
| 418.44 | 5.40 | 5.40 |
| 478.55 | 4.67 | 4.67 |
| 425.29 | 4.03 | 4.03 |
| 384.46 | 2.94 | 2.94 |
| 437.49 | 4.60 | 4.60 |
| 384.46 | 3.01 | 3.01 |
| 405.45 | 3.56 | 3.56 |
| 295.34 | 2.72 | 2.72 |
| 357.41 | 4.08 | 4.08 |
| 322.39 | 1.58 | 1.58 |
| 343.39 | 4.02 | 4.02 |
| 389.46 | 3.86 | 3.86 |
| 446.53 | 4.37 | 4.37 |
| 460.56 | 4.51 | 4.51 |
| 396.49 | 5.12 | 5.12 |
| 410.47 | 4.76 | 4.76 |
| 382.46 | 5.20 | 5.20 |
| 398.46 | 5.33 | 5.33 |
| 494.54 | 4.51 | 4.51 |
| 455.54 | 2.55 | 2.55 |
| 453.56 | 3.71 | 3.71 |