Basic Information
ID: ALA2404724
Type: Binding
Description: Inhibition of BACE1 in HEK293 cells expressing wild type human APP assessed as reduction in amyloid beta40 level after 18 to 20 hrs by AlphaLISA
Organism: Homo sapiens
Cell type: HEK293
Activity Charts
Bioactivity
Activity Types for Assay ALA2404724
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 371.83 | 2.03 | 2.03 |
| 372.88 | 3.65 | 3.65 |
| 362.79 | 3.08 | 3.08 |
| 330.78 | 2.55 | 2.55 |
| 312.40 | 2.61 | 2.61 |
| 357.80 | 1.99 | 1.99 |
| 376.85 | 3.97 | 3.97 |
| 342.79 | 2.47 | 2.47 |
| 358.85 | 3.19 | 3.19 |
| 371.83 | 2.38 | 2.38 |
| 375.84 | 2.99 | 2.99 |
| 357.85 | 2.51 | 2.51 |
| 397.24 | 3.73 | 3.73 |
| 362.79 | 2.73 | 2.73 |
| 397.24 | 3.38 | 3.38 |
| 358.85 | 3.26 | 3.26 |
| 386.86 | 4.27 | 4.27 |
| 372.83 | 3.74 | 3.74 |
| 408.86 | 4.30 | 4.30 |
| 410.84 | 4.10 | 4.10 |
| 376.82 | 3.47 | 3.47 |
| 376.82 | 3.12 | 3.12 |
| 376.82 | 3.12 | 3.12 |
| 374.80 | 2.73 | 2.73 |