Basic Information
ID: ALA2405592
Type: Binding
Description: Inhibition of 11beta-HSD2 in human kidney microsomes using [3H]-cortisol as substrate assessed as formation of cortisone at 100 uM after 30 mins by radiometric analysis relative to control
Organism: Homo sapiens
Tissue: Kidney
Subcellular Fraction: Microsome
Activity Charts
Bioactivity
Activity Types for Assay ALA2405592
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 368.39 | 3.85 | 3.85 |
| 266.30 | 3.39 | 3.39 |
| 326.35 | 3.41 | 3.41 |
| 454.52 | 4.96 | 4.96 |
| 440.49 | 4.57 | 4.57 |
| 534.65 | 6.73 | 6.73 |
| 386.49 | 6.04 | 6.04 |
| 346.43 | 5.11 | 5.11 |
| 434.53 | 5.79 | 5.79 |
| 520.62 | 6.34 | 6.34 |
| 352.39 | 3.94 | 3.94 |
| 360.50 | 5.04 | 5.04 |
| 346.47 | 4.65 | 4.65 |
| 320.44 | 4.11 | 4.11 |
| 462.63 | 5.18 | 5.18 |
| 306.36 | 4.32 | 4.32 |
| 292.33 | 3.93 | 3.93 |
| 432.15 | 6.43 | 6.43 |
| 348.44 | 5.31 | 5.31 |
| 270.28 | 4.26 | 4.26 |
| 460.57 | 6.33 | 6.33 |
| 392.09 | 5.51 | 5.51 |
| 362.47 | 5.70 | 5.70 |
| 296.32 | 4.79 | 4.79 |
| 418.13 | 6.04 | 6.04 |
| 414.45 | 4.03 | 4.03 |
| 446.54 | 6.05 | 6.05 |
| 474.60 | 6.72 | 6.72 |
| 310.34 | 5.18 | 5.18 |
| 418.13 | 6.04 | 6.04 |
| 432.31 | 6.83 | 6.83 |
| 322.40 | 4.78 | 4.78 |
| 372.46 | 5.65 | 5.65 |
| 432.52 | 5.66 | 5.66 |
| 494.58 | 5.81 | 5.81 |
| 406.48 | 5.13 | 5.13 |