Basic Information
ID: ALA2405606
Type: Binding
Description: Inhibition of 11beta-HSD1 in human liver microsomes using [3H]-cortisone as substrate assessed as formation of cortisol at 100 uM after 60 to 90 mins by radiometric analysis relative to control
Format: BAO_0000251
Organism: Homo sapiens
Tissue: Liver
Subcellular Fraction: Microsome
Target: 11-beta-hydroxysteroid dehydrogenase 1(ALA4235)
Document: ALA2401685
Inhibition of 11beta-HSD1 in human liver microsomes using [3H]-cortisone as substrate assessed as formation of cortisol at 100 uM after 60 to 90 mins by radiometric analysis relative to control: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA2405606
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 454.52 | 4.96 | 4.96 |
| 440.49 | 4.57 | 4.57 |
| 534.65 | 6.73 | 6.73 |
| 386.49 | 6.04 | 6.04 |
| 346.43 | 5.11 | 5.11 |
| 434.53 | 5.79 | 5.79 |
| 520.62 | 6.34 | 6.34 |
| 352.39 | 3.94 | 3.94 |
| 360.50 | 5.04 | 5.04 |
| 346.47 | 4.65 | 4.65 |
| 320.44 | 4.11 | 4.11 |
| 462.63 | 5.18 | 5.18 |
| 292.33 | 3.93 | 3.93 |
| 348.44 | 5.31 | 5.31 |
| 270.28 | 4.26 | 4.26 |
| 460.57 | 6.33 | 6.33 |
| 362.47 | 5.70 | 5.70 |
| 414.45 | 4.03 | 4.03 |
| 446.54 | 6.05 | 6.05 |
| 474.60 | 6.72 | 6.72 |
| 432.31 | 6.83 | 6.83 |
| 322.40 | 4.78 | 4.78 |
| 372.46 | 5.65 | 5.65 |
| 432.52 | 5.66 | 5.66 |
| 494.58 | 5.81 | 5.81 |
| 406.48 | 5.13 | 5.13 |