Basic Information
ID: ALA2423246
Type: Binding
Description: Inhibition of C-terminal FLAG-tagged human recombinant autotaxin using synthetic substrate FS-3 at 10 uM measured every 2 mins by FRET assay relative to control
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA2423246
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 429.56 | 4.60 | 4.60 |
| 488.36 | 3.87 | 3.87 |
| 378.43 | 2.94 | 2.94 |
| 489.35 | 4.51 | 4.51 |
| 496.01 | 6.03 | 6.03 |
| 678.82 | 9.35 | 9.35 |
| 519.13 | 9.76 | 9.76 |
| 313.40 | 4.63 | 4.63 |
| 295.43 | 5.70 | 5.70 |
| 491.08 | 8.98 | 8.98 |
| 369.46 | 5.93 | 5.93 |
| 462.37 | 4.06 | 4.06 |
| 463.54 | 2.24 | 2.24 |
| 490.65 | 4.65 | 4.65 |
| 471.61 | 4.89 | 4.89 |
| 427.50 | 2.25 | 2.25 |
| 447.54 | 2.54 | 2.54 |
| 486.48 | 4.01 | 4.01 |
| 390.51 | 4.52 | 4.52 |
| 430.49 | 5.17 | 5.17 |
| 514.99 | 7.10 | 7.10 |
| 486.62 | 5.71 | 5.71 |
| 490.56 | 3.86 | 3.86 |
| 391.45 | 4.60 | 4.60 |
| 443.52 | 5.49 | 5.49 |
| 416.50 | 5.21 | 5.21 |
| 502.62 | 5.42 | 5.42 |
| 1059.35 | ||
| 474.05 | 6.46 | 6.46 |
| 467.59 | 5.38 | 5.38 |
| 333.37 | 0.96 | 0.96 |
| 416.57 | 2.40 | 2.40 |
| 500.40 | 6.72 | 6.72 |
| 594.59 | 7.14 | 7.14 |
| 723.75 | 9.24 | 9.24 |
| 453.54 | 0.55 | 0.55 |
| 603.81 | 5.00 | 5.00 |
| 467.57 | 1.28 | 1.28 |
| 441.49 | -0.36 | -0.36 |
| 419.48 | -0.55 | -0.55 |
| 435.51 | 3.22 | 3.22 |
| 452.56 | 4.50 | 4.50 |
| 491.63 | 4.64 | 4.64 |
| 487.60 | 4.55 | 4.55 |
| 428.51 | 1.91 | 1.91 |
| 473.53 | 4.34 | 4.34 |
| 450.45 | 2.70 | 2.70 |
| 442.52 | 4.09 | 4.09 |
| 474.61 | 4.02 | 4.02 |
| 482.58 | 4.50 | 4.50 |
| 497.58 | 3.96 | 3.96 |
| 422.57 | 2.42 | 2.42 |
| 407.46 | 2.95 | 2.95 |
| 471.58 | 6.96 | 6.96 |
| 418.85 | 4.37 | 4.37 |
| 506.63 | 7.47 | 7.47 |
| 575.43 | 6.81 | 6.81 |
| 435.55 | 5.81 | 5.81 |
| 417.56 | 5.38 | 5.38 |
| 458.34 | 3.87 | 3.87 |
| 613.33 | 6.35 | 6.35 |
| 820.56 | 10.73 | 10.73 |
| 497.64 | 4.39 | 4.39 |
| 549.62 | 3.72 | 3.72 |
| 517.63 | 3.82 | 3.82 |
| 499.59 | 1.62 | 1.62 |
| 480.61 | 1.96 | 1.96 |
| 477.56 | 4.26 | 4.26 |
| 505.57 | 2.96 | 2.96 |
| 530.38 | 5.24 | 5.24 |
| 530.63 | 1.22 | 1.22 |
| 602.64 | 2.56 | 2.56 |
| 396.40 | 2.57 | 2.57 |
| 527.61 | 2.33 | 2.33 |
| 516.60 | 0.83 | 0.83 |
| 477.54 | 3.10 | 3.10 |
| 594.69 | 2.07 | 2.07 |
| 426.43 | 2.58 | 2.58 |
| 601.75 | 10.87 | 10.87 |
| 469.63 | 2.25 | 2.25 |
| 386.41 | 3.71 | 3.71 |
| 598.79 | 6.87 | 6.87 |
| 441.85 | 4.21 | 4.21 |
| 395.46 | 2.50 | 2.50 |
| 542.42 | 1.68 | 1.68 |
| 736.82 | 7.43 | 7.43 |
| 489.33 | 3.20 | 3.20 |
| 708.90 | 8.16 | 8.16 |
| 496.55 | 6.13 | 6.13 |
| 467.57 | 0.94 | 0.94 |
| 313.35 | 3.72 | 3.72 |
| 467.53 | 0.36 | 0.36 |
| 533.63 | 4.17 | 4.17 |
| 437.50 | -1.25 | -1.25 |
| 523.66 | 0.21 | 0.21 |
| 527.61 | 2.33 | 2.33 |
| 595.70 | 5.96 | 5.96 |
| 495.62 | 1.70 | 1.70 |
| 565.67 | 5.95 | 5.95 |
| 501.59 | 1.60 | 1.60 |
| 467.53 | 0.36 | 0.36 |
| 513.68 | 2.69 | 2.69 |
| 453.54 | 0.55 | 0.55 |
| 499.66 | 2.30 | 2.30 |
| 335.40 | 5.01 | 5.01 |
| 481.55 | 0.75 | 0.75 |
| 471.56 | 4.41 | 4.41 |
| 477.61 | 4.66 | 4.66 |
| 495.00 | 2.70 | 2.70 |
| 469.54 | 4.36 | 4.36 |
| 496.63 | 4.51 | 4.51 |
| 418.50 | 3.32 | 3.32 |
| 404.43 | 2.61 | 2.61 |
| 489.62 | 3.93 | 3.93 |
| 495.58 | 4.40 | 4.40 |
| 444.60 | 5.97 | 5.97 |
| 438.53 | 4.16 | 4.16 |
| 452.58 | 4.16 | 4.16 |
| 458.63 | 3.84 | 3.84 |
| 469.97 | 5.74 | 5.74 |
| 499.59 | 5.43 | 5.43 |
| 529.02 | 6.97 | 6.97 |
| 419.48 | 5.29 | 5.29 |
| 403.53 | 5.88 | 5.88 |
| 488.59 | 5.95 | 5.95 |
| 514.40 | 5.05 | 5.05 |
| 438.89 | 5.29 | 5.29 |
| 549.39 | 4.02 | 4.02 |
| 519.36 | 4.01 | 4.01 |
| 631.70 | 8.09 | 8.09 |
| 486.52 | 3.63 | 3.63 |
| 435.48 | 2.48 | 2.48 |
| 599.68 | 7.35 | 7.35 |
| 552.65 | 2.31 | 2.31 |
| 505.66 | 2.42 | 2.42 |
| 584.72 | 3.29 | 3.29 |
| 650.76 | 5.89 | 5.89 |
| 595.70 | 5.96 | 5.96 |
| 591.75 | 3.33 | 3.33 |
| 579.70 | 6.26 | 6.26 |
| 565.67 | 5.95 | 5.95 |
| 509.65 | 2.09 | 2.09 |
| 493.61 | 2.41 | 2.41 |
| 655.75 | 5.98 | 5.98 |
| 625.72 | 5.97 | 5.97 |
| 625.72 | 5.97 | 5.97 |
| 655.75 | 5.98 | 5.98 |
| 494.68 | 3.39 | 3.39 |
| 460.57 | 3.75 | 3.75 |
| 453.56 | 4.32 | 4.32 |
| 487.64 | 4.59 | 4.59 |
| 463.60 | 3.87 | 3.87 |
| 472.59 | 4.32 | 4.32 |
| 428.95 | 4.02 | 4.02 |
| 500.00 | 4.89 | 4.89 |
| 545.02 | 6.48 | 6.48 |
| 435.53 | 4.70 | 4.70 |
| 478.89 | 4.72 | 4.72 |
| 523.04 | 6.60 | 6.60 |
| 516.64 | 5.25 | 5.25 |
| 437.52 | 3.72 | 3.72 |
| 472.36 | 4.17 | 4.17 |
| 458.34 | 3.87 | 3.87 |
| 541.67 | 5.91 | 5.91 |
| 526.01 | 4.85 | 4.85 |
| 502.39 | 4.18 | 4.18 |
| 511.60 | 5.35 | 5.35 |
| 366.44 | 3.67 | 3.67 |
| 498.40 | 4.81 | 4.81 |
| 626.11 | 6.45 | 6.45 |
| 604.21 | 4.45 | 4.45 |
| 527.71 | 7.04 | 7.04 |
| 408.50 | 1.70 | 1.70 |
| 579.65 | 3.73 | 3.73 |
| 731.98 | 6.23 | 6.23 |
| 421.50 | 5.05 | 5.05 |
| 622.90 | 5.88 | 5.88 |
| 493.61 | 2.41 | 2.41 |
| 591.75 | 3.33 | 3.33 |
| 619.85 | 4.67 | 4.67 |
| 625.81 | 4.58 | 4.58 |
| 577.77 | 3.53 | 3.53 |
| 618.86 | 11.34 | 11.34 |
| 423.42 | 5.02 | 5.02 |
| 500.60 | 3.44 | 3.44 |
| 615.73 | 7.11 | 7.11 |
| 484.62 | 2.96 | 2.96 |
| 481.66 | 5.32 | 5.32 |
| 807.03 | 5.26 | 5.26 |