Basic Information
ID: ALA2432690
Type: ADME
Description: Inhibition of CYP2C9 in human liver microsomes assessed as tolbutamide hydroxylation to hydroxytolbutamide at 1 uM after 10 mins relative to control
Format: BAO_0000251
Organism: Homo sapiens
Tissue: Liver
Subcellular Fraction: Microsome
Target: Cytochrome P450 2C9(ALA3397)
Document: ALA2429844
Inhibition of CYP2C9 in human liver microsomes assessed as tolbutamide hydroxylation to hydroxytolbutamide at 1 uM after 10 mins relative to control: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA2432690
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 531.44 | 4.21 | 4.21 |
| 631.13 | 5.14 | 5.14 |
| 514.51 | 5.63 | 5.63 |
| 526.54 | 5.50 | 5.50 |
| 503.54 | 5.22 | 5.22 |
| 602.64 | 7.07 | 7.07 |
| 512.52 | 5.19 | 5.19 |
| 493.54 | 4.93 | 4.93 |
| 502.55 | 5.08 | 5.08 |
| 539.01 | 6.51 | 6.51 |
| 493.54 | 5.43 | 5.43 |
| 487.54 | 3.52 | 3.52 |
| 626.71 | 4.19 | 4.19 |
| 523.01 | 3.09 | 3.09 |
| 478.53 | 5.35 | 5.35 |
| 478.53 | 5.35 | 5.35 |
| 496.52 | 5.49 | 5.49 |
| 496.52 | 5.49 | 5.49 |
| 496.52 | 5.49 | 5.49 |
| 514.51 | 5.63 | 5.63 |
| 514.51 | 5.63 | 5.63 |
| 512.97 | 6.00 | 6.00 |
| 512.97 | 6.00 | 6.00 |
| 512.97 | 6.00 | 6.00 |
| 420.42 | 3.82 | 3.82 |
| 420.42 | 3.82 | 3.82 |
| 481.33 | 4.44 | 4.44 |
| 481.33 | 4.44 | 4.44 |
| 452.49 | 4.84 | 4.84 |
| 452.49 | 4.84 | 4.84 |
| 513.40 | 5.46 | 5.46 |
| 390.49 | 3.81 | 3.81 |
| 390.49 | 3.81 | 3.81 |