Basic Information
ID: ALA2434293
Type: ADME
Description: Inhibition of CYP3A4 in human liver microsomes assessed as midazolam hydroxylation to 1'-hydroxymidazolam at 10 uM after 10 mins relative to control
Format: BAO_0000251
Organism: Homo sapiens
Tissue: Liver
Subcellular Fraction: Microsome
Target: Cytochrome P450 3A4(ALA340)
Document: ALA2429844
Inhibition of CYP3A4 in human liver microsomes assessed as midazolam hydroxylation to 1'-hydroxymidazolam at 10 uM after 10 mins relative to control: 1
Activity Charts
Bioactivity
Activity Types for Assay ALA2434293
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 314.37 | 2.26 | 2.26 |
| 324.42 | 3.17 | 3.17 |
| 502.55 | 5.08 | 5.08 |
| 539.01 | 6.51 | 6.51 |
| 487.54 | 3.52 | 3.52 |
| 523.01 | 3.09 | 3.09 |
| 460.54 | 5.21 | 5.21 |
| 460.54 | 5.21 | 5.21 |
| 402.43 | 3.68 | 3.68 |
| 476.54 | 5.34 | 5.34 |
| 452.44 | 4.56 | 4.56 |
| 414.47 | 3.55 | 3.55 |
| 418.88 | 4.20 | 4.20 |
| 434.50 | 4.70 | 4.70 |
| 404.51 | 3.82 | 3.82 |
| 406.49 | 3.51 | 3.51 |
| 496.61 | 5.39 | 5.39 |
| 426.47 | 4.05 | 4.05 |
| 398.47 | 3.47 | 3.47 |
| 412.49 | 3.86 | 3.86 |
| 426.52 | 4.25 | 4.25 |
| 442.52 | 3.87 | 3.87 |
| 480.49 | 4.88 | 4.88 |
| 444.51 | 4.39 | 4.39 |
| 384.44 | 3.54 | 3.54 |
| 402.43 | 3.68 | 3.68 |
| 390.49 | 3.81 | 3.81 |
| 390.49 | 3.81 | 3.81 |
| 420.51 | 3.82 | 3.82 |
| 408.50 | 4.02 | 4.02 |
| 427.94 | 2.23 | 2.23 |
| 441.96 | 2.57 | 2.57 |
| 441.96 | 2.57 | 2.57 |
| 424.91 | 4.04 | 4.04 |