Basic Information
ID: ALA2449559
Type: Binding
Description: SUPPLEMENTARY: Inhibition of P-glycoprotein expressed in MDR CCRF vcr1000 cells by daunorubicin efflux assay. Same assay as CHEMBL914418
Format: BAO_0000219
Organism: Homo sapiens
Cell type: CCRF-CEM/VCR-1000
Target: P-glycoprotein 1(ALA4302)
Document: ALA2449286
SUPPLEMENTARY: Inhibition of P-glycoprotein expressed in MDR CCRF vcr1000 cells by daunorubicin efflux assay. Same assay as CHEMBL914418: 21
Activity Charts
Bioactivity
Activity Types for Assay ALA2449559
EC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 341.45 | 3.24 | 3.24 |
| 308.38 | 2.92 | 2.92 |
| 232.28 | 1.35 | 1.35 |
| 372.44 | 2.59 | 2.59 |
| 369.51 | 3.58 | 3.58 |
| 407.60 | 6.32 | 6.32 |
| 323.44 | 4.25 | 4.25 |
| 323.44 | 4.25 | 4.25 |
| 291.39 | 2.42 | 2.42 |
| 351.49 | 4.76 | 4.76 |
| 337.46 | 4.37 | 4.37 |
| 365.52 | 5.15 | 5.15 |
| 379.54 | 5.54 | 5.54 |
| 393.57 | 5.93 | 5.93 |
| 341.45 | 3.24 | 3.24 |
| 341.45 | 3.24 | 3.24 |
| 369.50 | 3.58 | 3.58 |
| 369.51 | 3.58 | 3.58 |
| 369.51 | 3.58 | 3.58 |
| 369.51 | 3.58 | 3.58 |
| 351.49 | 4.01 | 4.01 |
| 338.88 | 2.72 | 2.72 |
| 512.63 | 5.36 | 5.36 |
| 508.66 | 5.53 | 5.53 |
| 232.28 | 1.35 | 1.35 |
| 308.38 | 2.92 | 2.92 |
| 232.28 | 1.35 | 1.35 |
| 308.38 | 2.92 | 2.92 |
| 349.47 | 3.22 | 3.22 |
| 374.48 | 3.09 | 3.09 |
| 388.51 | 3.43 | 3.43 |
| 388.51 | 3.43 | 3.43 |
| 388.51 | 3.43 | 3.43 |
| 346.43 | 2.45 | 2.45 |
| 346.43 | 2.45 | 2.45 |
| 360.45 | 2.79 | 2.79 |
| 360.45 | 2.79 | 2.79 |
| 300.36 | 2.31 | 2.31 |
| 300.36 | 2.31 | 2.31 |
| 300.36 | 2.31 | 2.31 |
| 272.30 | 1.67 | 1.67 |
| 286.33 | 2.02 | 2.02 |
| 272.30 | 1.67 | 1.67 |
| 286.33 | 2.02 | 2.02 |
| 314.39 | 2.65 | 2.65 |
| 314.39 | 2.65 | 2.65 |
| 314.39 | 2.65 | 2.65 |
| 314.39 | 2.65 | 2.65 |
| 422.53 | 3.67 | 3.67 |
| 422.53 | 3.67 | 3.67 |
| 348.40 | 2.90 | 2.90 |
| 348.40 | 2.90 | 2.90 |
| 304.39 | 1.74 | 1.74 |
| 304.39 | 1.74 | 1.74 |
| 318.42 | 2.08 | 2.08 |
| 318.42 | 2.08 | 2.08 |
| 336.86 | 3.33 | 3.33 |
| 336.86 | 3.33 | 3.33 |
| 318.37 | 1.83 | 1.83 |
| 318.37 | 1.83 | 1.83 |
| 346.43 | 2.45 | 2.45 |
| 355.48 | 3.58 | 3.58 |
| 367.49 | 3.73 | 3.73 |
| 383.53 | 4.36 | 4.36 |
| 291.39 | 2.50 | 2.50 |
| 277.36 | 2.11 | 2.11 |
| 444.58 | 4.06 | 4.06 |
| 474.60 | 4.07 | 4.07 |
| 474.60 | 4.07 | 4.07 |
| 474.60 | 4.07 | 4.07 |
| 458.60 | 4.37 | 4.37 |
| 458.60 | 4.06 | 4.06 |
| 462.57 | 4.20 | 4.20 |
| 293.36 | 1.35 | 1.35 |
| 327.42 | 2.80 | 2.80 |
| 279.34 | 0.96 | 0.96 |
| 355.48 | 3.58 | 3.58 |
| 327.42 | 3.00 | 3.00 |
| 365.47 | 3.81 | 3.81 |
| 369.46 | 2.57 | 2.57 |
| 459.59 | 4.23 | 4.23 |
| 367.49 | 3.73 | 3.73 |
| 383.53 | 4.23 | 4.23 |
| 247.34 | 3.03 | 3.03 |
| 456.59 | 5.08 | 5.08 |
| 457.61 | 5.20 | 5.20 |
| 357.45 | 2.95 | 2.95 |
| 462.57 | 4.20 | 4.20 |
| 367.49 | 3.73 | 3.73 |
| 369.46 | 2.57 | 2.57 |
| 464.58 | 4.05 | 4.05 |
| 478.61 | 4.71 | 4.71 |
| 462.57 | 4.20 | 4.20 |
| 383.53 | 4.36 | 4.36 |
| 385.55 | 4.21 | 4.21 |
| 399.58 | 4.87 | 4.87 |
| 417.55 | 4.88 | 4.88 |
| 479.62 | 5.66 | 5.66 |
| 465.59 | 5.62 | 5.62 |
| 543.71 | 7.21 | 7.21 |