Basic Information
ID: ALA3097488
Type: Binding
Description: Inverse agonist activity at N-terminal 6xHis-tagged human RORc ligand binding domain (241 to 486) expressed in bacterial expression system assessed as inhibition of SRC1 co-activator peptide recruitment after 3 hrs by TR-FRET analysis relative to apo-RORc ligand binding domain
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA3097488
Efficacy
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 481.34 | 4.76 | 4.76 |
| 425.35 | 3.75 | 3.75 |
| 427.37 | 4.21 | 4.21 |
| 506.35 | 4.63 | 4.63 |
| 506.35 | 4.63 | 4.63 |
| 506.35 | 4.63 | 4.63 |
| 495.36 | 5.06 | 5.06 |
| 499.33 | 4.90 | 4.90 |
| 482.32 | 4.15 | 4.15 |
| 495.36 | 4.90 | 4.90 |
| 443.37 | 3.19 | 3.19 |
| 495.36 | 5.15 | 5.15 |
| 489.44 | 5.39 | 5.39 |
| 495.36 | 5.41 | 5.41 |
| 427.37 | 4.21 | 4.21 |
| 445.28 | 5.21 | 5.21 |
| 477.41 | 3.52 | 3.52 |