Assay Report Card

Basic Information

ID: ALA3106784

Type: Binding

Description: Inhibition of recombinant perforin (unknown origin)-mediated lysis of human [51Cr]-labelled Jurkat cells assessed as release of [51Cr] preincubated for 30 mins followed by addition of cells measured after 4 hrs by gamma counting analysis

Organism: Homo sapiens

Cell type: Jurkat

Activity Charts

Bioactivity

Activity Types for Assay ALA3106784

IC50

Total(68)

Compound Summary

Parent Molecular Weight	ALogP	Polar Surface Area
400.46	3.17	3.17
452.61	3.20	3.20
369.47	2.91	2.91
341.42	2.00	2.00
355.44	2.35	2.35
355.44	2.05	2.05
355.44	2.05	2.05
369.47	2.39	2.39
369.47	2.39	2.39
381.48	3.45	3.45
325.35	1.84	1.84
341.42	2.00	2.00
335.39	1.94	1.94
335.39	1.94	1.94
336.38	1.34	1.34
374.43	2.42	2.42
374.43	2.42	2.42
388.45	2.47	2.47
388.45	2.47	2.47
456.59	2.21	2.21
373.46	1.48	1.48
387.49	1.87	1.87
387.49	1.87	1.87
403.49	0.84	0.84
341.42	2.00	2.00
355.44	2.35	2.35
369.47	2.74	2.74
383.50	3.13	3.13
397.52	3.52	3.52
383.50	3.12	3.12
427.51	2.28	2.28
385.47	1.71	1.71
399.50	2.10	2.10
415.50	1.07	1.07
383.45	2.26	2.26
413.48	2.87	2.87
454.58	2.05	2.05
426.57	2.67	2.67
466.63	3.59	3.59
481.65	2.35	2.35
286.38	2.76	2.76
320.83	3.41	3.41
320.83	3.41	3.41
320.83	3.41	3.41
304.37	2.90	2.90
304.37	2.90	2.90
322.36	3.04	3.04
354.38	3.78	3.78
354.38	3.78	3.78
311.39	2.63	2.63
302.38	2.47	2.47
388.82	4.43	4.43
365.28	3.52	3.52
332.48	3.48	3.48
328.42	2.96	2.96
358.44	2.82	2.82
344.42	2.55	2.55
329.41	1.86	1.86
329.41	1.86	1.86
358.44	2.86	2.86
364.47	2.16	2.16
379.49	2.13	2.13
287.37	2.16	2.16
287.37	2.16	2.16
343.43	2.12	2.12
357.46	2.46	2.46
399.50	2.23	2.23
442.57	1.82	1.82