Assay Report Card

Basic Information

ID: ALA3107136

Type: Binding

Description: Inhibition of human HPGD in human ME180 cells assessed as downregulation of TNFalpha-induced NF-kappaB expression at 647 pM to 38.2 uM incubated for 15 mins prior to TNFalpha addition measured after 4 to 24 hrs by beta-lactamase reporter gene assay

Organism: Homo sapiens

Cell type: ME-180

Activity Charts

Compound Summary

Parent Molecular WeightALogPPolar Surface Area
352.473.253.25
401.853.303.30
144.13-0.11-0.11
340.864.734.73
339.834.314.31
361.494.954.95
318.465.095.09