Basic Information
ID: ALA3110728
Type: Binding
Description: Inhibition of RIP1 in human U937 cells assessed as prevention of TNFalpha/zVAD.fmk-induced necrotic cell death preincubated for 30 to 60 mins followed by TNF-alpha induction measured after overnight incubation by Cell Titer-Glo luminescence assay
Organism: Homo sapiens
Cell type: U-937
Activity Charts
Bioactivity
Activity Types for Assay ALA3110728
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 431.35 | 5.27 | 5.27 |
| 481.36 | 6.15 | 6.15 |
| 413.36 | 5.13 | 5.13 |
| 447.80 | 5.79 | 5.79 |
| 395.42 | 5.27 | 5.27 |
| 404.47 | 6.54 | 6.54 |
| 582.58 | 7.49 | 7.49 |
| 422.41 | 6.15 | 6.15 |
| 440.40 | 6.29 | 6.29 |
| 440.40 | 6.29 | 6.29 |
| 440.40 | 6.29 | 6.29 |
| 440.40 | 6.29 | 6.29 |
| 456.86 | 6.80 | 6.80 |
| 456.86 | 6.80 | 6.80 |
| 401.47 | 5.41 | 5.41 |
| 418.50 | 6.85 | 6.85 |
| 449.47 | 6.45 | 6.45 |
| 472.47 | 7.56 | 7.56 |
| 434.50 | 6.55 | 6.55 |
| 446.51 | 6.74 | 6.74 |
| 490.46 | 7.70 | 7.70 |
| 396.49 | 5.96 | 5.96 |
| 491.45 | 7.09 | 7.09 |
| 533.49 | 6.80 | 6.80 |
| 568.55 | 7.10 | 7.10 |
| 505.48 | 7.28 | 7.28 |
| 505.48 | 7.28 | 7.28 |
| 480.43 | 6.42 | 6.42 |
| 431.35 | 5.27 | 5.27 |
| 431.35 | 5.27 | 5.27 |
| 431.35 | 5.27 | 5.27 |
| 447.80 | 5.79 | 5.79 |
| 373.42 | 4.68 | 4.68 |
| 379.81 | 4.77 | 4.77 |
| 392.42 | 4.40 | 4.40 |