Basic Information
ID: ALA3110730
Type: Binding
Description: Displacement of (14-(2-{[3-({2-{[4-(cyanomethyl)phenyl]amino}-6-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]-4-pyrimidinyl}amino)propyl]amino}-2-oxoethyl)-16,16,18,18-tetramethyl-6,7,7a,8a,9,10,16,18-octahydrobenzo[2'',3'']indolizino[8'',7'':5',6']pyrano[3',2':3,4]pyrido[1,2-a]indol-5-ium-2-sulfonate from human N-terminal His-GST-TEV-fused RIP1 kinase domain (1 to 375) expressed in baculovirus infected insect Sf9 cells preincubated for 10 mins followed by fluorescent ligand addition measured after 15 mins by fluorescence polarization assay
Organism: Homo sapiens
Cell type: Sf9
Activity Charts
Bioactivity
Activity Types for Assay ALA3110730
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 431.35 | 5.27 | 5.27 |
| 481.36 | 6.15 | 6.15 |
| 413.36 | 5.13 | 5.13 |
| 447.80 | 5.79 | 5.79 |
| 395.42 | 5.27 | 5.27 |
| 404.47 | 6.54 | 6.54 |
| 582.58 | 7.49 | 7.49 |
| 422.41 | 6.15 | 6.15 |
| 440.40 | 6.29 | 6.29 |
| 440.40 | 6.29 | 6.29 |
| 440.40 | 6.29 | 6.29 |
| 440.40 | 6.29 | 6.29 |
| 456.86 | 6.80 | 6.80 |
| 456.86 | 6.80 | 6.80 |
| 401.47 | 5.41 | 5.41 |
| 418.50 | 6.85 | 6.85 |
| 449.47 | 6.45 | 6.45 |
| 472.47 | 7.56 | 7.56 |
| 434.50 | 6.55 | 6.55 |
| 446.51 | 6.74 | 6.74 |
| 490.46 | 7.70 | 7.70 |
| 396.49 | 5.96 | 5.96 |
| 491.45 | 7.09 | 7.09 |
| 533.49 | 6.80 | 6.80 |
| 568.55 | 7.10 | 7.10 |
| 505.48 | 7.28 | 7.28 |
| 505.48 | 7.28 | 7.28 |
| 480.43 | 6.42 | 6.42 |
| 431.35 | 5.27 | 5.27 |
| 431.35 | 5.27 | 5.27 |
| 431.35 | 5.27 | 5.27 |
| 447.80 | 5.79 | 5.79 |
| 373.42 | 4.68 | 4.68 |
| 379.81 | 4.77 | 4.77 |
| 392.42 | 4.40 | 4.40 |