Basic Information
ID: ALA3111195
Type: Binding
Description: Inhibition of TLR2/6 in BALB/c mouse BMDM assessed as downregulation of BLP-stimulated IL-12p40 level at 5 ug/ml preincubated for 18 hrs followed by BLP challenge measured after 24 hrs by ELISA relative to control
Organism: Mus musculus
Strain: BALB/c
Activity Charts
Bioactivity
Activity Types for Assay ALA3111195
Inhibition
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 264.32 | 0.76 | 0.76 |
| 255.34 | 0.79 | 0.79 |
| 232.33 | 1.44 | 1.44 |
| 271.41 | 1.51 | 1.51 |
| 248.33 | 0.68 | 0.68 |
| 220.32 | 1.30 | 1.30 |
| 299.37 | 1.57 | 1.57 |
| 222.29 | 0.99 | 0.99 |
| 248.33 | 1.52 | 1.52 |
| 236.31 | 1.38 | 1.38 |
| 287.34 | 0.58 | 0.58 |
| 313.38 | 1.11 | 1.11 |
| 329.38 | 0.35 | 0.35 |
| 335.27 | 1.82 | 1.82 |
| 301.37 | 0.97 | 0.97 |
| 270.40 | 1.37 | 1.37 |
| 274.36 | 1.20 | 1.20 |
| 256.37 | 1.06 | 1.06 |
| 334.44 | 1.59 | 1.59 |
| 318.44 | 2.36 | 2.36 |
| 292.40 | 1.82 | 1.82 |
| 344.48 | 2.84 | 2.84 |
| 268.38 | 1.20 | 1.20 |
| 284.38 | 0.44 | 0.44 |
| 242.34 | 0.67 | 0.67 |
| 363.28 | 1.20 | 1.20 |
| 347.28 | 1.96 | 1.96 |
| 321.24 | 1.43 | 1.43 |
| 298.41 | 0.75 | 0.75 |
| 282.41 | 1.51 | 1.51 |
| 256.37 | 0.98 | 0.98 |
| 329.38 | 0.35 | 0.35 |
| 313.38 | 1.11 | 1.11 |
| 287.34 | 0.58 | 0.58 |
| 302.37 | 0.58 | 0.58 |
| 286.37 | 1.34 | 1.34 |
| 260.33 | 0.81 | 0.81 |
| 313.47 | 0.91 | 0.91 |
| 378.34 | 1.36 | 1.36 |
| 382.44 | 0.55 | 0.55 |
| 366.44 | 1.32 | 1.32 |
| 340.40 | 0.78 | 0.78 |
| 228.32 | 0.99 | 0.99 |
| 254.35 | 1.52 | 1.52 |
| 270.35 | 0.76 | 0.76 |
| 246.31 | 1.13 | 1.13 |
| 272.35 | 1.66 | 1.66 |
| 288.34 | 0.90 | 0.90 |
| 303.40 | 1.06 | 1.06 |
| 285.41 | 0.92 | 0.92 |
| 206.29 | 0.91 | 0.91 |
| 267.39 | 2.01 | 2.01 |
| 332.26 | 2.46 | 2.46 |
| 245.32 | 1.30 | 1.30 |
| 302.42 | 1.23 | 1.23 |
| 287.36 | 1.07 | 1.07 |
| 271.36 | 1.84 | 1.84 |
| 245.32 | 1.30 | 1.30 |
| 287.36 | 1.07 | 1.07 |
| 271.36 | 1.84 | 1.84 |
| 302.42 | 1.23 | 1.23 |
| 273.37 | 2.13 | 2.13 |
| 273.37 | 2.13 | 2.13 |
| 334.28 | 2.75 | 2.75 |
| 334.28 | 2.75 | 2.75 |
| 416.36 | 2.07 | 2.07 |
| 383.30 | 1.62 | 1.62 |
| 409.33 | 2.15 | 2.15 |
| 474.20 | 2.60 | 2.60 |
| 346.29 | 2.85 | 2.85 |
| 320.25 | 2.32 | 2.32 |
| 362.29 | 2.09 | 2.09 |
| 281.42 | 2.40 | 2.40 |
| 255.38 | 1.86 | 1.86 |
| 297.42 | 1.63 | 1.63 |
| 504.23 | 2.23 | 2.23 |
| 462.19 | 2.46 | 2.46 |
| 488.23 | 2.99 | 2.99 |
| 423.36 | 2.54 | 2.54 |
| 397.32 | 2.01 | 2.01 |
| 270.40 | 0.95 | 0.95 |
| 239.34 | 1.56 | 1.56 |
| 241.36 | 1.85 | 1.85 |
| 241.36 | 1.85 | 1.85 |
| 256.37 | 0.61 | 0.61 |
| 227.33 | 1.46 | 1.46 |
| 227.33 | 1.46 | 1.46 |
| 243.33 | 0.43 | 0.43 |
| 241.36 | 1.85 | 1.85 |
| 268.38 | 0.71 | 0.71 |
| 242.34 | 0.67 | 0.67 |
| 268.38 | 1.20 | 1.20 |
| 284.38 | 0.44 | 0.44 |
| 321.24 | 1.43 | 1.43 |
| 347.28 | 1.96 | 1.96 |
| 363.28 | 1.20 | 1.20 |
| 260.33 | 0.81 | 0.81 |
| 286.37 | 1.34 | 1.34 |
| 302.37 | 0.58 | 0.58 |
| 256.37 | 0.98 | 0.98 |
| 282.41 | 1.51 | 1.51 |
| 298.41 | 0.75 | 0.75 |
| 464.08 | 2.86 | 2.86 |
| 322.14 | 2.71 | 2.71 |
| 257.27 | 2.26 | 2.26 |
| 288.24 | 1.86 | 1.86 |
| 271.30 | 2.65 | 2.65 |
| 374.37 | 3.48 | 3.48 |
| 306.23 | 1.93 | 1.93 |
| 241.36 | 1.47 | 1.47 |