Basic Information
ID: ALA3132106
Type: Binding
Description: Inhibition of N-terminal 6-His-tagged full-length human 11beta-HSD1 assessed as conversion of cortisone to cortisol after 25 mins by competitive HTRF assay
Organism: Homo sapiens
Activity Charts
Bioactivity
Activity Types for Assay ALA3132106
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 456.59 | 2.61 | 2.61 |
| 440.59 | 2.21 | 2.21 |
| 378.49 | 2.67 | 2.67 |
| 422.55 | 2.69 | 2.69 |
| 436.57 | 3.08 | 3.08 |
| 443.57 | 3.34 | 3.34 |
| 448.59 | 3.22 | 3.22 |
| 348.47 | 2.70 | 2.70 |
| 362.50 | 3.09 | 3.09 |
| 376.52 | 3.48 | 3.48 |
| 378.49 | 2.06 | 2.06 |
| 392.52 | 2.72 | 2.72 |
| 406.55 | 3.10 | 3.10 |
| 406.55 | 3.10 | 3.10 |
| 404.53 | 3.21 | 3.21 |
| 418.56 | 3.25 | 3.25 |
| 388.53 | 3.48 | 3.48 |
| 413.54 | 3.37 | 3.37 |
| 366.55 | 3.62 | 3.62 |
| 360.40 | 3.14 | 3.14 |
| 332.47 | 3.00 | 3.00 |
| 362.50 | 2.97 | 2.97 |
| 362.50 | 2.97 | 2.97 |
| 376.52 | 3.23 | 3.23 |
| 348.47 | 2.66 | 2.66 |
| 392.52 | 2.81 | 2.81 |
| 406.55 | 2.85 | 2.85 |
| 363.48 | 2.25 | 2.25 |
| 377.51 | 2.71 | 2.71 |
| 391.54 | 2.73 | 2.73 |
| 454.62 | 3.42 | 3.42 |
| 456.59 | 2.61 | 2.61 |
| 305.38 | 1.10 | 1.10 |
| 322.43 | 2.13 | 2.13 |
| 308.40 | 1.82 | 1.82 |
| 278.38 | 1.81 | 1.81 |
| 306.43 | 2.43 | 2.43 |
| 336.46 | 2.52 | 2.52 |
| 390.43 | 3.06 | 3.06 |
| 350.48 | 2.91 | 2.91 |
| 362.50 | 3.05 | 3.05 |
| 364.47 | 1.90 | 1.90 |