Basic Information
ID: ALA3137362
Type: Functional
Description: MMV: Growth inhibition of P. falciparum cultures was quantified using a parasite lactate dehydrogenase (LDH) assay. The cultures were diluted to 0.5% parasitemea and 2% hematocrit and subjected to each twofold serial dilutions of the compounds for 72 h (DMSO final concentration, 0.25%). After 72 h, the cultures were frozen. LDH activity of P. falciparum parasites in aliquots of freeze-thawed cultures was spectrophotometrically measured and the IC50s were determined.
Organism: Plasmodium falciparum
Strain: FCR3
Activity Charts
Bioactivity
Activity Types for Assay ALA3137362
IC50
Compound Summary
| Parent Molecular Weight | ALogP | Polar Surface Area |
|---|---|---|
| 350.03 | 5.94 | 5.94 |
| 267.36 | 4.26 | 4.26 |
| 368.66 | 4.80 | 4.80 |
| 367.28 | 3.70 | 3.70 |
| 383.67 | 4.94 | 4.94 |
| 448.37 | 7.15 | 7.15 |
| 341.44 | 5.94 | 5.94 |
| 574.24 | 5.29 | 5.29 |
| 328.17 | 4.12 | 4.12 |
| 366.35 | 5.45 | 5.45 |
| 340.40 | 3.76 | 3.76 |
| 458.63 | 5.30 | 5.30 |
| 470.17 | 6.64 | 6.64 |
| 356.43 | 4.99 | 4.99 |
| 283.71 | 4.01 | 4.01 |
| 326.40 | 4.99 | 4.99 |
| 362.43 | 3.88 | 3.88 |
| 359.43 | 5.61 | 5.61 |
| 356.43 | 5.57 | 5.57 |
| 349.22 | 4.08 | 4.08 |
| 286.76 | 4.34 | 4.34 |
| 389.54 | 4.17 | 4.17 |
| 390.51 | 4.42 | 4.42 |
| 366.89 | 3.95 | 3.95 |
| 468.47 | 5.09 | 5.09 |
| 436.01 | 5.10 | 5.10 |
| 360.24 | 4.22 | 4.22 |
| 458.86 | 5.49 | 5.49 |
| 327.43 | 4.18 | 4.18 |
| 314.82 | 4.55 | 4.55 |
| 395.53 | 5.20 | 5.20 |
| 400.46 | 4.42 | 4.42 |
| 315.84 | 4.99 | 4.99 |
| 315.68 | 4.32 | 4.32 |
| 416.29 | 4.16 | 4.16 |
| 393.31 | 4.23 | 4.23 |
| 341.33 | 0.31 | 0.31 |
| 311.39 | 4.85 | 4.85 |
| 341.41 | 4.86 | 4.86 |
| 348.31 | 4.54 | 4.54 |