Assay Report Card

Basic Information

ID: ALA3137725

Type: Toxicity

Description: Highest frequency of acute liver toxicity observed during clinical trials, expressed as a percentage. [column '% AIGUE' in source]

Organism: Homo sapiens

Tissue: Liver

Activity Charts

Compound Summary

Parent Molecular WeightALogPPolar Surface Area
383.411.781.78
361.371.541.54
232.241.421.42
357.793.933.93
369.341.701.70
334.350.760.76
331.351.581.58
319.341.271.27
270.374.794.79
236.14-1.06-1.06
264.373.083.08
280.423.883.88
365.842.082.08
441.554.374.37
430.382.882.88
284.753.153.15
267.371.611.61
391.566.866.86
268.364.834.83
252.271.771.77
804.034.644.64
314.864.534.53
216.192.552.55
543.530.000.00
236.28-1.42-1.42
222.25-0.86-0.86
172.21-0.08-0.08
290.321.261.26
454.615.095.09
398.403.703.70
146.141.791.79
414.533.373.37
266.340.450.45
180.161.311.31
407.514.954.95
341.430.560.56
302.242.912.91
259.352.582.58
266.341.381.38
156.061.401.40
334.400.860.86
416.361.891.89
252.350.600.60
375.401.981.98
328.412.142.14
401.442.372.37
327.360.380.38
389.390.970.97
325.372.112.11
297.75-0.35-0.35
330.751.891.89
248.722.522.52
357.353.563.56
255.321.531.53
250.280.860.86
242.341.351.35
581.671.991.99
300.445.605.60
262.311.311.31
232.240.700.70
309.334.444.44
326.833.723.72
263.383.833.83
399.975.975.97
299.762.952.95
315.723.043.04
267.311.671.67
280.310.870.87
224.260.960.96
393.474.514.51
303.143.613.61
331.183.753.75
350.833.343.34
250.343.573.57
232.281.861.86
293.373.133.13
430.728.848.84
385.512.092.09
211.220.440.44
276.381.961.96
267.332.852.85
375.874.434.43
340.432.882.88
354.495.655.65
266.302.652.65
444.49-0.14-0.14
347.242.922.92
76.05-0.96-0.96
137.14-0.31-0.31
258.230.090.09
255.272.292.29
272.371.091.09
494.013.643.64
243.394.334.33
59.07-0.64-0.64
182.190.070.07
370.595.895.89
369.373.523.52
586.694.094.09
273.19-0.44-0.44
299.371.501.50
318.874.894.89
266.393.533.53
387.525.705.70
232.281.351.35
319.884.814.81
329.373.333.33
351.411.561.56
473.596.086.08
371.526.006.00
654.613.193.19
441.642.852.85
421.451.851.85
419.383.703.70
410.493.593.59
468.372.112.11
299.802.002.00
853.923.743.74
261.091.881.88
276.751.741.74
248.331.911.91
300.05
160.180.920.92
924.090.710.71
416.136.456.45
236.302.732.73
198.272.702.70
379.504.364.36
404.554.204.20
259.352.782.78
184.111.211.21
296.154.744.74
440.954.634.63
214.051.161.16
233.702.252.25
304.223.383.38
287.414.704.70
187.201.021.02
339.483.363.36
333.361.611.61
206.283.073.07
357.793.933.93
178.273.643.64
331.351.581.58
383.41-0.56-0.56
308.383.793.79
278.363.953.95
749.001.901.90
314.504.274.27
733.941.791.79
314.474.724.72
528.681.771.77
426.564.134.13
309.434.014.01
137.140.970.97
344.855.385.38
334.33-1.65-1.65
265.351.991.99
306.280.740.74
300.445.605.60
324.403.813.81
399.442.872.87
355.850.850.85
236.273.393.39
144.212.292.29
417.392.902.90
404.352.042.04
260.251.111.11
560.690.920.92
179.262.032.03
776.874.564.56
496.47-1.29-1.29
238.332.852.85
351.351.801.80
352.772.812.81
244.263.683.68
284.434.244.24
242.703.063.06
151.161.351.35
254.283.403.40
179.222.042.04
403.983.943.94
286.722.452.45
356.424.374.37
297.144.414.41
228.343.103.10
352.435.265.26
254.293.113.11
238.160.070.07
290.833.643.64
123.110.780.78
380.420.950.95
376.451.601.60
321.163.103.10
131.392.502.50
359.402.282.28
670.863.093.09
613.802.872.87
567.804.754.75
505.642.402.40
253.270.830.83
381.383.513.51
395.462.552.55
369.432.742.74
144.601.511.51
471.696.456.45
456.572.722.72
356.453.163.16
357.442.492.49
207.231.311.31
351.411.951.95
163.20-0.49-0.49
131.13-0.62-0.62
77.15-0.13-0.13
341.411.531.53
575.695.705.70
314.362.562.56
241.680.820.82
339.393.863.86
199.640.420.42
382.543.953.95
516.869.919.91
246.312.792.79
291.732.852.85
387.441.061.06
454.913.963.96
331.41-0.21-0.21
123.11-0.42-0.42
283.331.581.58
200.17-0.02-0.02
396.450.590.59
407.585.685.68
337.351.121.12
383.47-0.31-0.31
371.872.362.36
287.363.383.38
481.514.634.63
470.023.553.55
201.252.692.69
356.493.663.66
188.231.481.48
278.310.190.19
277.414.174.17
341.453.243.24
392.471.901.90
645.326.946.94
358.431.771.77
277.413.043.04
267.24-0.20-0.20
349.322.182.18
323.130.910.91
235.331.341.34
336.432.372.37
284.434.244.24
360.451.561.56
294.444.124.12
325.452.372.37
343.224.234.23
266.393.023.02
374.481.801.80
414.353.443.44
230.102.362.36
265.362.482.48
371.282.682.68
272.393.613.61
255.363.353.35
308.773.583.58
277.414.214.21
126.00-0.16-0.16
171.160.090.09
150.221.081.08
275.404.554.55
398.471.761.76
189.220.160.16
360.844.684.68
367.810.620.62
262.652.822.82
1297.30
244.292.672.67
199.300.700.70
295.302.972.97
281.234.154.15
296.154.364.36
241.293.753.75
329.495.435.43
143.140.370.37
141.170.450.45
379.462.972.97
411.460.870.87
249.301.461.46
213.661.861.86
517.56-0.24-0.24
153.140.670.67
451.481.721.72
412.953.813.81
389.461.351.35
372.553.813.81
222.242.852.85
240.232.992.99
229.26-0.59-0.59
239.311.311.31
312.443.443.44
383.522.862.86
331.874.884.88
420.324.534.53
230.312.612.61
406.483.743.74
437.534.314.31
167.200.600.60
334.783.293.29
328.412.142.14
373.954.584.58
628.814.334.33
303.32-0.08-0.08
256.102.012.01
404.505.395.39
237.732.902.90
268.362.222.22
234.202.782.78
371.352.482.48
212.230.620.62
308.380.530.53
525.786.676.67
274.403.493.49
256.091.931.93
350.40-1.89-1.89
102.09-1.62-1.62
608.694.174.17
550.725.865.86
269.134.004.00
270.351.781.78
194.191.501.50
586.208.958.95
354.10-1.22-1.22
612.633.633.63
505.464.184.18
458.553.923.92
303.362.062.06
233.312.092.09
454.450.270.27
359.471.551.55
331.340.880.88
364.36-0.32-0.32
190.21-0.96-0.96
209.25-0.13-0.13
230.263.043.04
378.324.454.45
243.22-2.56-2.56
440.613.913.91
276.213.213.21
381.695.805.80
255.752.552.55
306.245.185.18
194.15-2.08-2.08
266.101.781.78
317.233.843.84
312.422.322.32
318.343.203.20
157.22-0.21-0.21
311.411.771.77
401.441.901.90
287.300.640.64
246.31-0.28-0.28
291.444.884.88
320.320.660.66
326.474.444.44
361.833.553.55
182.17-0.23-0.23
327.813.773.77
404.493.803.80
231.301.551.55
263.793.963.96
235.07-1.66-1.66
435.44-1.17-1.17
546.59-1.30-1.30
424.502.572.57
368.302.012.01
295.73-0.06-0.06
279.341.811.81
149.210.150.15
392.412.082.08
295.454.374.37
305.211.931.93
211.22-0.50-0.50
246.271.041.04
368.525.115.11
204.31-0.29-0.29
260.242.862.86
588.561.341.34
570.933.743.74
545.632.582.58
1449.27
249.10-1.27-1.27
206.03-0.99-0.99
348.442.122.12
810.993.993.99
1202.63
365.842.712.71
321.340.540.54
464.554.184.18
263.20-1.29-1.29
435.892.552.55
470.333.203.20
239.753.303.30
285.372.202.20
250.203.043.04
518.566.386.38
337.46-0.77-0.77
484.645.105.10
543.530.000.00
214.272.192.19
315.875.195.19
400.984.244.24
434.534.604.60
307.403.253.25
501.675.515.51
467.491.371.37
240.211.871.87
246.19-1.68-1.68
178.190.420.42
404.345.505.50
554.59-1.20-1.20
395.42-0.17-0.17
308.312.762.76
197.382.512.51
504.64-0.02-0.02
338.504.364.36
309.454.194.19
226.23-0.49-0.49
720.965.915.91
171.241.371.37
493.624.594.59
284.362.952.95
211.331.581.58
319.412.922.92
42.04-0.57-0.57
229.63-1.08-1.08
305.291.781.78
217.230.890.89
200.280.820.82
543.61
551.634.204.20
179.312.552.55
270.213.253.25
310.340.880.88
296.553.623.62
387.894.004.00
187.292.182.18
285.433.883.88
255.231.521.52
282.223.543.54
705.655.585.58
312.412.532.53
218.250.980.98
309.393.063.06
228.302.932.93
286.465.515.51
514.59-1.04-1.04
224.22-0.71-0.71
222.280.750.75
397.954.434.43
247.342.492.49
427.460.100.10
349.14-1.49-1.49
319.230.500.50
382.894.894.89
388.903.153.15
346.474.994.99
300.753.373.37
139.150.400.40
337.381.641.64
366.554.834.83
197.190.050.05
237.301.451.45
349.770.710.71
411.473.423.42
440.464.034.03
144.220.250.25
257.292.192.19
398.35
277.505.305.30
261.091.881.88
207.230.310.31
266.344.664.66
223.320.190.19
299.813.693.69
248.311.681.68
183.190.120.12
380.660.820.82
338.770.920.92
415.50-0.32-0.32
385.853.983.98
371.434.524.52
330.473.843.84
418.574.594.59
287.362.352.35
369.504.024.02
435.534.164.16
352.484.364.36
268.741.401.40
257.333.033.03
228.293.373.37
293.324.034.03
364.423.043.04
445.552.082.08
418.975.785.78
161.662.232.23
427.534.114.11
262.362.992.99
334.172.892.89
253.721.721.72
129.160.360.36
824.973.523.52
365.410.020.02
136.200.690.69
267.25-1.98-1.98
238.240.960.96
204.231.301.30
354.193.913.91
242.711.751.75
179.220.720.72
288.443.903.90
225.160.970.97
500.438.648.64
379.443.683.68
432.503.413.41
311.433.813.81
313.793.433.43
497.501.021.02
281.362.952.95
278.221.151.15
341.10
244.22-0.54-0.54
326.445.175.17
812.024.934.93
122.130.180.18
337.464.504.50
260.27-1.60-1.60
424.532.442.44
409.822.702.70
327.343.053.05
462.51-0.23-0.23
348.432.532.53
298.433.493.49
429.564.044.04
332.35-2.93-2.93
416.522.382.38
153.140.670.67
367.882.092.09
176.180.600.60
152.180.640.64
287.361.921.92
261.714.094.09
270.341.231.23
555.723.063.06
443.643.473.47
284.454.254.25
299.363.953.95
262.220.840.84
378.410.490.49
359.452.992.99
247.280.530.53
205.261.281.28
388.821.571.57
261.92
324.383.493.49
312.411.291.29
192.262.512.51
272.700.800.80
260.332.022.02
405.501.241.24
255.372.652.65
213.242.662.66
364.445.305.30
374.914.044.04
264.332.432.43
184.492.352.35
461.472.642.64
126.081.711.71
184.492.352.35
415.574.114.11
372.813.143.14
90.03-0.84-0.84
128.160.430.43
452.605.225.22
317.222.452.45
214.210.580.58
346.855.045.04
473.417.497.49
324.423.173.17
525.64-0.65-0.65
258.232.312.31
242.273.673.67
531.444.214.21
363.803.293.29
324.423.173.17
280.332.132.13
362.412.422.42
163.20-0.49-0.49
273.724.164.16
279.382.982.98
221.301.051.05
273.242.552.55
313.312.792.79
448.974.024.02
205.260.240.24
164.972.032.03
169.140.220.22
475.635.245.24
495.756.886.88
324.34-0.80-0.80
318.612.072.07
371.25
290.36-0.62-0.62
475.520.940.94
349.410.320.32
169.180.080.08
430.542.722.72
415.833.473.47
251.712.902.90
169.571.771.77
363.503.313.31
384.432.602.60
260.313.173.17
173.21-1.45-1.45
253.742.212.21
387.483.743.74
261.252.352.35
325.505.345.34
817.86
484.50-7.29-7.29
298.433.643.64
312.453.883.88
326.485.185.18
344.504.084.08
416.584.854.85
302.464.274.27
585.61-8.42-8.42
581.58-8.16-8.16
527.531.031.03
293.372.932.93
411.461.001.00
266.341.121.12
183.10-0.60-0.60
323.421.631.63
318.504.604.60
86.14-0.82-0.82
625.765.055.05
400.596.356.35
461.565.865.86
288.433.883.88
152.180.640.64
425.923.353.35
822.954.344.34
418.452.972.97
184.21-1.69-1.69
392.471.901.90
255.23-1.97-1.97
225.21-1.33-1.33
339.37-0.40-0.40
1069.24
130.08-0.80-0.80
149.210.110.11
552.63-6.40-6.40
129.17-1.03-1.03
447.53-3.85-3.85
444.44-0.35-0.35
457.480.190.19
454.52-0.64-0.64
424.39-0.54-0.54
453.882.692.69
480.57-1.28-1.28
516.725.675.67
332.31-3.58-3.58
444.44-0.21-0.21
166.251.281.28
236.300.810.81
458.501.981.98
427.420.670.67
828.013.013.01
362.471.781.78
414.482.482.48
424.095.465.46
308.774.054.05
315.684.074.07
336.453.333.33
406.55-0.86-0.86
384.440.550.55
366.845.515.51
211.221.621.62
180.17-1.04-1.04
204.302.152.15
433.502.522.52
369.491.291.29
236.23-0.21-0.21
129.09-0.51-0.51
308.333.613.61
353.333.523.52
280.324.044.04
336.302.902.90
136.110.060.06
518.095.145.14
847.024.624.62
179.20-0.78-0.78
697.784.754.75
753.942.732.73
459.564.884.88
365.98
392.584.484.48
318.301.741.74
337.464.224.22
384.263.963.96
490.633.073.07
265.343.243.24
479.533.683.68
416.883.193.19
317.343.383.38
422.924.274.27
474.591.611.61
558.656.316.31
252.101.171.17
244.21-3.17-3.17
301.474.334.33
281.444.574.57
408.882.272.27
376.144.564.56
388.852.792.79
391.474.414.41
304.322.982.98
337.575.565.56
338.443.463.46
481.552.402.40
360.451.991.99
346.342.182.18
383.382.882.88
345.422.902.90
428.544.784.78
442.42-0.44-0.44
114.170.710.71
445.613.283.28
460.44-1.24-1.24
475.684.024.02
170.241.381.38
430.552.772.77
231.263.253.25
248.311.961.96
1415.58
246.351.771.77
289.740.880.88
304.474.214.21
339.353.653.65
335.883.783.78
387.53-1.31-1.31
461.500.090.09
453.46-0.54-0.54
277.271.151.15
569.61-7.52-7.52
372.09-1.27-1.27
265.360.610.61
478.890.440.44
450.719.169.16
392.584.484.48
1255.44
926.110.940.94
217.290.630.63
152.242.402.40
315.37-0.31-0.31
467.654.414.41
645.61-8.56-8.56
404.475.015.01
594.67-0.59-0.59
333.350.770.77
285.24-1.84-1.84
89.090.100.10
168.582.062.06
656.662.752.75
98.140.780.78
475.59-3.20-3.20
196.260.050.05
440.415.185.18
455.554.404.40
311.411.901.90
360.240.600.60
360.372.572.57
268.27-1.18-1.18
368.471.941.94
417.511.601.60
465.531.301.30
410.584.984.98
356.061.231.23
367.452.232.23
408.922.172.17
368.482.572.57
439.891.661.66
324.402.212.21
464.860.260.26
438.522.572.57
570.776.836.83
271.341.061.06
184.241.031.03
423.470.480.48
457.43-3.11-3.11
542.58-0.92-0.92
349.410.350.35
410.43-0.05-0.05
253.353.243.24
575.63-1.40-1.40
811.883.163.16
1701.21
813.982.772.77
785.896.166.16
285.69-0.30-0.30
776.874.564.56
343.905.105.10
392.335.185.18
473.571.101.10
905.044.284.28
1325.56
353.471.941.94
244.21-3.01-3.01
363.390.150.15
350.443.293.29
371.392.582.58
405.976.226.22
415.804.164.16
390.873.823.82
843.062.332.33
1101.28
627.985.555.55
320.055.935.93
427.46-0.54-0.54
620.742.302.30
645.68-1.11-1.11
421.421.631.63
278.341.481.48
116.07-0.29-0.29
186.241.561.56
371.473.283.28
385.382.462.46
1039.86
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388.423.203.20
347.400.440.44
465.953.363.36
455.47-0.62-0.62
539.59-0.23-0.23
451.52-5.27-5.27
813.983.623.62
778.954.754.75
315.692.532.53
289.163.593.59
285.320.370.37
268.27-2.71-2.71
747.962.442.44
298.382.842.84
467.52-6.30-6.30
780.952.222.22
424.990.390.39
378.523.173.17
138.06-0.09-0.09
225.291.521.52
192.261.591.59
328.484.504.50
316.433.073.07
452.552.612.61
321.833.673.67
359.350.760.76
329.814.764.76
446.643.183.18
221.261.791.79
232.241.701.70
282.302.552.55
398.45-3.26-3.26
371.823.183.18
510.48-0.17-0.17
257.25-1.76-1.76
359.676.046.04
1139.76
477.564.264.26
212.302.632.63
564.44-1.13-1.13
280.310.870.87
121.14-2.34-2.34
306.453.543.54
387.725.865.86
386.805.035.03
332.484.404.40
428.314.364.36
1736.18
200.052.422.42
273.741.621.62
168.042.082.08
244.25-0.05-0.05
183.251.131.13
232.281.231.23
777.09-1.01-1.01
557.610.830.83
519.57-0.71-0.71
182.22-0.25-0.25
389.481.411.41
384.524.584.58
231.251.421.42
1096.35
471.55-0.73-0.73
1209.42
69.72
612.650.330.33
613.913.123.12
511.57-0.87-0.87
353.534.114.11
1269.43
388.462.582.58
314.261.741.74
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354.37-1.44-1.44
357.322.712.71
274.803.823.82
339.441.921.92
421.474.524.52
370.433.533.53
398.503.293.29
389.432.372.37
322.504.394.39
259.784.064.06
314.732.582.58
339.484.284.28
357.350.990.99
837.062.212.21
128.151.451.45
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178.57-0.26-0.26
541.550.870.87
44.01-0.16-0.16
121.76
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356.230.400.40
263.382.632.63
527.570.470.47
1085.16
32.05-1.18-1.18
866.971.271.27
414.460.250.25
298.351.021.02
321.164.094.09
1784.20
429.605.415.41
519.59-1.84-1.84
515.54-2.49-2.49
436.964.194.19
493.54-1.36-1.36
294.444.424.42
275.09
260.08
312.763.823.82
298.351.531.53
379.891.601.60
180.281.671.67
159.192.252.25
297.381.721.72
300.444.054.05
383.534.454.45
219.630.700.70
320.393.953.95
313.293.113.11
266.303.933.93
422.584.154.15
218.282.062.06
295.454.684.68
314.864.074.07
296.393.423.42
403.442.892.89
263.363.523.52
175.230.970.97
300.362.062.06
248.96
420.482.222.22
285.273.823.82
374.43-1.76-1.76
466.41-2.88-2.88
550.62-2.64-2.64
1287.92
253.260.790.79
206.312.502.50
279.383.963.96
657.81
1093.33
624.875.465.46
439.582.412.41
1215.82
265.22-2.89-2.89
513.610.460.46
318.833.783.78
478.635.015.01
504.44-7.73-7.73
222.25-0.50-0.50
556.532.982.98
268.19-0.26-0.26
339.513.933.93
327.812.912.91
302.464.274.27
282.761.821.82
645.672.252.25
137.191.301.30
477.442.052.05
415.471.511.51
168.191.621.62
263.28-0.23-0.23
238.083.013.01
460.15
314.411.461.46
42.081.171.17
264.321.891.89
308.423.723.72
232.281.871.87
156.190.540.54
366.872.692.69
474.511.491.49
828.013.163.16
348.454.254.25
320.763.253.25
627.66-2.84-2.84
136.201.211.21
434.522.762.76
166.220.920.92
375.424.714.71
425.39-3.85-3.85
583.60-7.95-7.95
452.554.024.02
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556.60-2.32-2.32
328.504.124.12
313.69-2.28-2.28
564.57
491.543.823.82
397.44-0.17-0.17
670.68-0.61-0.61
602.64-0.45-0.45
1131.40
326.474.444.44
203.251.111.11
323.474.364.36
260.341.961.96
405.451.691.69
673.670.950.95
378.555.165.16
204.270.990.99
331.822.702.70
342.444.054.05
400.658.428.42
367.493.713.71
267.311.671.67
578.662.692.69
334.423.433.43
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672.744.554.55
522.57-3.16-3.16
269.26-1.99-1.99
300.794.234.23
1127.71
751.931.881.88
653.641.731.73
449.531.731.73
441.552.382.38
244.21-3.17-3.17
209.21-0.63-0.63
288.433.883.88
304.302.202.20
344.504.704.70
323.463.793.79
238.333.273.27
440.974.654.65
379.503.863.86
206.251.381.38
345.093.893.89
355.821.611.61
284.444.314.31
278.363.043.04
322.362.972.97
339.33-0.80-0.80
399.482.472.47
7.95
411.474.634.63
2296.97
1321.44
584.681.001.00
1112.37
627.641.551.55
405.976.566.56
1767.46
324.382.522.52
567.651.361.36
835.092.202.20
1390.73
563.676.126.12
405.50-3.59-3.59
376.585.515.51
208.311.851.85
680.97
362.63
1464.34
212.00
878.92
695.851.641.64
593.65-0.19-0.19
1315.57
538.63
261.201.901.90
523.341.411.41
322.244.704.70
76.64
416.21
2045.33
303.18
532.62
394.523.793.79
369.532.482.48
497.02
559.05
1713.10
360.34-0.73-0.73
196.97
916.03
232.04
583.60
908.39
414.371.091.09
296.09
246.30
463.561.321.32
331.471.321.32
365.41-0.07-0.07
354.533.773.77
389.430.710.71
1019.26
532.56-1.89-1.89
861.943.263.26
461.500.830.83
3431.91
266.39
430.391.061.06
326.441.551.55
740.761.541.54